Explanipedia

Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis Open

Bishuang Cai, Fanglin Ma, Yu Liu, Xu Yang, Wenli Liu , et al. · 2025

Background Macrophages are key players in the pathogenesis of atherosclerosis. They trigger immune responses through their cell-surface receptors. However, how macrophages regulate those receptors in response to pro-inflammatory stimuli is…

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease Open

Moritz von Scheidt, Shaunak Adkar, Johannes Krefting, Gregor Hoermann, Manja Meggendorfer , et al. · 2025

Background and Aims Clonal haematopoiesis of indeterminate potential (CHIP) has been associated with cardiovascular risk, but its prognostic relevance and mechanistic role in coronary artery disease (CAD) remains incompletely understood. T…

KLK15 alters connective tissues in hypermobile Ehlers-Danlos syndrome Open

Cortney Gensemer, Taylor Petrucci, Tyler Beck, Victoria Daylor BFA, Molly Griggs , et al. · 2025

Hypermobile Ehlers-Danlos syndrome (hEDS) is a debilitating multisystem condition characterized by joint hypermobility, chronic pain, and diverse comorbidities, yet its genetic basis remains undefined. Whole-exome sequencing (WES) of 200 p…

Aortic valve leaflet motion for diagnosis and classification of aortic stenosis using single view echocardiography. Open

Thomas Meredith, Farhan Mohammed, Amy Pomeroy, Sebastiano Barbieri, Erik Meijering , et al. · 2025

Advancing severity of AS is associated with significantly reduced linear and angular leaflet displacement. Leaflet motion data can accurately classify AS using a single parasternal long axis view, without the need for hemodynamic or Dopple…

Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques Open

Katyayani Sukhavasi, Giuseppe Mocci, Lijiang Ma, Chani J. Hodonsky, Ernest Diez Benavente , et al. · 2025

Spontaneous Coronary Artery Dissection and a Family History of Aortic Dissection: A Genetic Association Study Open

Lucy McGrath‐Cadell, Stephanie Hesselson, Ingrid Tarr, Emma M. Rath, Michael Troup , et al. · 2025

Background Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndrome or sudden cardiac death, primarily affecting relatively young women (median age, 51 years) without typical cardiovascul…

Polygenic risk scores point toward potential genetic mechanisms of type 2 myocardial infarction in people with HIV Open

Won Jun Lee, Haoxiang Cheng, Bridget M. Whitney, Robin M. Nance, Sierra R. Britton , et al. · 2025

Plasma proteins are integral to gene-regulatory networks acting within and across blood cells, the arterial wall and major metabolic organs Open

Sean Bankier, Husain A. Talukdar, Muhammad Jaseem Khan, Giuseppe Mocci, Katyayani Sukhavasi , et al. · 2025

SUMMARY The plasma proteome is the future for diagnostic markers for common diseases, like cardiometabolic disorders (CMDs) and coronary artery disease (CAD). The reliability of these markers requires identifying their source-organ(s). We …

Infiltrative Myocardial T-Cell Lymphoma Open

A. Podgórski, D. Tardo, Callum Cherrett, Orly Lavee, Jason C. Kovacic · 2024

We report a unique case involving cardiac manifestation of T-cell lymphoma and associated risk management of ventricular arrhythmia and sudden cardiac death. A 39-year-old woman presented with a syndrome consistent with fever in a returned…

Spontaneous Coronary Artery Dissection Open

Daniela R. Crousillat, Amy Sarma, Malissa J. Wood, Sahar Naderi, Katherine Leon , et al. · 2024

Despite marked advancements in the recognition and diagnosis of spontaneous coronary artery dissection (SCAD) over the past decade, knowledge of the basic pathophysiologic mechanisms of disease, contributing factors, and treatment continue…

The national Cardiovascular Health Leadership Research Forum: a new data‐driven model placing research at the centre of improving patient outcomes Open

Gemma A. Figtree, Kerry Doyle, Lee Nedkoff, Dominique A. Cadilhac, Jason C. Kovacic · 2024

A Call to Action to Improve Cardiac Arrest Outcomes: A Report From the National Summit for Cardiac Arrest Open

André La Gerche, E. Paratz, Janet Bray, Garry Jennings, Greg Page , et al. · 2024

Sudden cardiac arrest (SCA) represents a major cause of premature mortality globally, with enormous impact and financial cost to victims, families, and communities. SCA prevention should be considered a health priority in Australia. Nation…

Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia Open

Valentina d’Escamard, Daniella Kadian‐Dodov, Lijiang Ma, Sizhao Lu, Annette King , et al. · 2024

Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis Open

Yang Xu, Adam H. Korayem, A.S. Cruz-Solbes, Nirupama Chandel, Tomoki Sakata , et al. · 2024

Aims Vein grafts are used for many indications, including bypass graft surgery and arteriovenous fistula (AVF) formation. However, patency following vein grafting or AVF formation is suboptimal for various reasons, including thrombosis, ne…

Variants in the Kallikrein Gene Family and Hypermobile Ehlers-Danlos Syndrome Open

Cortney Gensemer, Tyler Beck, Lilong Guo, Taylor Petrucci, Jordan Morningstar , et al. · 2024

Hypermobile Ehlers-Danlos syndrome (hEDS) is a common heritable connective tissue disorder that lacks a known genetic etiology. To identify genetic contributions to hEDS, whole exome sequencing was performed on families and a cohort of spo…

Water, Soil, Noise, and Light Pollution Open

Mark R. Miller, Philip J. Landrigan, Manish Arora, David E. Newby, Thomas Münzel , et al. · 2024

COL3A1 Variants in Spontaneous Coronary Artery Dissection Open

Lucy McGrath‐Cadell, Stephanie Hesselson, J. L. Thompson, Siiri E. Iismaa, Ingrid Tarr , et al. · 2024

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis Open

Giuseppe Mocci, Katyayani Sukhavasi, Tiit Örd, Sean Bankier, Prosanta Singha , et al. · 2024

BACKGROUND: While our understanding of the single-cell gene expression patterns underlying the transformation of vascular cell types during the progression of atherosclerosis is rapidly improving, the clinical and pathophysiological releva…

Therapeutic targeting of cell transition: ready for clinical prime-time? Open

Emiel P. C. van der Vorst, Jason C. Kovacic · 2024

Heterogeneous Effects of Continuous Positive Airway Pressure in Non-Sleepy Obstructive Sleep Apnea on Cardiovascular Disease Outcomes: <i>Post Hoc</i> Machine Learning Analysis of the ISAACC Trial (ECSACT Study) Open

Oren Cohen, Manuel Sánchez‐de‐la‐Torre, Zainab Al-Taie, Samira Khan, Vaishnavi Kundel , et al. · 2024

Rationale: Randomized controlled trials of continuous positive airway pressure (CPAP) therapy for cardiovascular disease (CVD) prevention among patients with obstructive sleep apnea (OSA) have been largely neutral. However, given th…

Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease Open

Ignacio Fernando Hall, Franceska Kishta, Yang Xu, Andrew H. Baker, Jason C. Kovacic · 2024

Endothelial cells (ECs) line the luminal surface of blood vessels and play a major role in vascular (patho)-physiology by acting as a barrier, sensing circulating factors and intrinsic/extrinsic signals. ECs have the capacity to undergo en…

Polygenic Risk in Families With Spontaneous Coronary Artery Dissection Open

Ingrid Tarr, Stephanie Hesselson, Michael Troup, Paul Young, J. L. Thompson , et al. · 2024

Importance Spontaneous coronary artery dissection (SCAD) is a poorly understood cause of acute coronary syndrome that predominantly affects women. Evidence to date suggests a complex genetic architecture, while a family history is reported…

The protocol for an observational Australian cohort study of CADASIL: The AusCADASIL study Open

Danit Saks, Beata Bajorek, Vibeke S. Catts, Adam C. Bentvelzen, Jiyang Jiang , et al. · 2024

Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci Open

Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst , et al. · 2023

Getting to the cART of the Matter Open

D. Tardo, Andrew Jabbour, Jason C. Kovacic · 2023

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis Open

José Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky , et al. · 2023

Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence Open

Radoslav Savić, Jialiang Yang, Simon Koplev, Mahru C. An, Priyanka L. Patel , et al. · 2023

COL3A1 mutations in spontaneous coronary artery dissection Open

Lucy McGrath‐Cadell, S Hessleson, J. L. Thompson, Siiri E. Iismaa, Ingrid Tarr , et al. · 2023

Background Spontaneous coronary artery dissection (SCAD) affects mainly women with a mean age of 51 years.(1) Predicted damaging variants in connective tissue disease (CTD) genes have been found in a subset of patients with SCAD, however i…

Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification Open

Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong , et al. · 2023

Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors Open

Gemma A. Figtree, Stephen T. Vernon, Jason A. Harmer, Michael P. Gray, Clare Arnott , et al. · 2023

Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coronary ath…

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