Jason C. McCoy
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View article: Characterization of tolloid-mediated cleavage of the GDF8 procomplex
Characterization of tolloid-mediated cleavage of the GDF8 procomplex Open
Growth differentiation factor 8 (GDF8), a.k.a. myostatin, is a member of the larger TGFβ superfamily of signaling ligands. GDF8 has been well characterized as a negative regulator of muscle mass. After synthesis, GDF8 is held latent by a n…
View article: Structural perspective of BMP ligands and signaling
Structural perspective of BMP ligands and signaling Open
View article: Structural biology of the TGFβ family
Structural biology of the TGFβ family Open
The transforming growth factor beta (TGFβ) signaling pathway orchestrates a wide breadth of biological processes, ranging from bone development to reproduction. Given this, there has been a surge of interest from the drug development indus…
View article: Structure of the WFIKKN2 Follistatin domain and insight into GDF8/11 antagonism
Structure of the WFIKKN2 Follistatin domain and insight into GDF8/11 antagonism Open
Growth Differentiation Factor 8 (GDF8), also known as Myostatin, is a member of the TGF-β superfamily and is a potent negative regulator of skeletal muscle growth.Disruption of GDF8 signaling or injection of GDF8 inhibitors results in musc…
View article: Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans
Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans Open
Cleft lip with or without cleft palate (CL/P) is generally viewed as a complex trait with multiple genetic and environmental contributions. In 70% of cases, CL/P presents as an isolated feature and/or deemed nonsyndromic. In the remaining …
View article: Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11
Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11 Open
View article: Molecular characterization of latent GDF8 reveals mechanisms of activation
Molecular characterization of latent GDF8 reveals mechanisms of activation Open
Significance GDF8 is a signaling protein that inhibits muscle mass. Inhibitors of GDF8 are highly sought as therapeutics for the treatment of muscle-wasting diseases. During synthesis, GDF8 is made as a precursor where the signaling segmen…
View article: Structure of the human myostatin precursor and determinants of growth factor latency
Structure of the human myostatin precursor and determinants of growth factor latency Open
View article: Molecular characterization of latent GDF8 reveals mechanisms of activation
Molecular characterization of latent GDF8 reveals mechanisms of activation Open
Growth/differentiation factor 8 (GDF8) or myostatin negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. Using a combination of small angle X-ray scattering a…
View article: Structural basis for potency differences between GDF8 and GDF11
Structural basis for potency differences between GDF8 and GDF11 Open
View article: Baculovirus FP25K Localization: Role of the Coiled-Coil Domain
Baculovirus FP25K Localization: Role of the Coiled-Coil Domain Open
Two types of viruses are produced during the baculovirus life cycle: budded virus (BV) and occlusion-derived virus (ODV). A particular baculovirus protein, FP25K, is involved in the switch from BV to ODV production. Previously, FP25K from …