Explanipedia

A rapid pupillometry protocol for clinical use: Effect of age and test-retest repeatability Open

Jason C. Park, J. Jason McAnany · 2025

The mesopic negative response (MeNR): a novel approach to assess retinal ganglion cell function within the rod pathway Open

J. Jason McAnany, Jason C. Park, Pablo A. Barrionuevo, Dhara Shah, Thasarat S. Vajaranant , et al. · 2025

A Method to Evaluate the Frequency Dependence of Retinal Vascular and Neural Metrics to Stimulus Modulation Open

Anthony E. Felder, Giri Balasubramanian, Aldo Arroyo, Jason C. Park, Mahnaz Shahidi , et al. · 2025

The frequency-dependent response of retinal D, SO2, and OEF established in healthy individuals herein has the potential to serve as a biomarker of vascular and tissue abnormality in future studies of retinal disease.

Increment Thresholds in Retinitis Pigmentosa: Association With Retinal Thickness Open

Robert A. Hyde, Jason C. Park, J. Jason McAnany · 2025

Cone sensitivity loss in the d1 subgroup may be attributed to reduced quantal absorption, whereas cone sensitivity loss in the d3 subgroup may be better explained by a reduced cone density, consistent with their marked retinal thinning.

Brief report: harmonic analysis of the 30 Hz flicker ERG in early-stage diabetic retinopathy Open

J. Jason McAnany, Jason C. Park · 2025

Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy Open

Sugasini Dhavamani, Poorna C. R. Yalagala, Jason C. Park, Guangying Ma, Zeenat Farooq , et al. · 2024

Retinal DHA is reduced in diabetic humans and mice, which is associated with a thinning of retina and functional defects in diabetic mice. Enriching retinal DHA through diet may be beneficial in the prevention and treatment of diabetic ret…

Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study Open

Sirimon Reutrakul, Jason C. Park, J. Jason McAnany, Felix Y. Chau, Kirstie K. Danielson , et al. · 2024

THU341 Associations Of Longitudinal Nighttime Sleep Characteristics With Nighttime/Daytime Glucose Values As Assessed By Continuous Glucose Monitoring In Type 2 Diabetes Open

Yanliang Li, Kirstie K. Danielson, Jason C. Park, J. Jason McAnany, Felix Y. Chau , et al. · 2023

Disclosure: Y. Li: None. K.K. Danielson: None. J.C. Park: None. J. McAnany: None. F.Y. Chau: None. B. Prasad: None. E.C. Hanlon: None. S. Reutrakul: None. Background: Sleep disturbances have been shown to be associated with incident diabet…

THU315 Sleep And Circadian Regulation, And Intrinsically Photosensitive Retinal Ganglion Cells Function In Diabetic Retinopathy Open

Sirimon Reutrakul, J. Jason McAnany, Jason C. Park, Felix Y. Chau, Kirstie K. Danielson , et al. · 2023

Disclosure: S. Reutrakul: None. J.J. McAnany: None. J.C. Park: None. F.Y. Chau: None. K.K. Danielson: None. P. Bharati: None. S. Pannain: None. E. Van Cauter: None. E.C. Hanlon: None. Background: Diabetic retinopathy (DR) is associated wit…

Greater sleep variability is associated with higher systemic inflammation in type 2 diabetes Open

Sirimon Reutrakul, J. Jason McAnany, Jason C. Park, Felix Y. Chau, Kirstie K. Danielson , et al. · 2023

Summary Sleep irregularity and variability have been shown to be detrimental to cardiometabolic health. The present pilot study explored if higher day‐to‐day sleep irregularity and variability were associated with systemic inflammation, as…

Improvement of retinal function in Alzheimer disease-associated retinopathy by dietary lysophosphatidylcholine-EPA/DHA Open

Sugasini Dhavamani, Jason C. Park, J. Jason McAnany, Tae-Hoon Kim, Guangying Ma , et al. · 2023

Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography Open

Jason C. Park, Oksana Persidina, Giri Balasubramanian, Tara Nguyen, Anubhav Pradeep , et al. · 2023

Changes in the full-field flash and flicker electroretinogram (ERG) that accompany normal aging were evaluated in mice. ERGs were recorded from a single cohort of C57BL/6J mice from 5 to 70 weeks of age using conventional techniques. Dark-…

Rod photoreceptor activation and deactivation in early-stage diabetic eye disease Open

J. Jason McAnany, Jason C. Park · 2023

Visual Field Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Chromatic Perimetry Open

J. Jason McAnany, Jason C. Park, Jennifer I. Lim · 2023

Visual field sensitivity losses suggest neural abnormalities in early stage diabetic eye disease and the pattern of the sensitivity losses differed depending on the adaptation conditions. Chromatic perimetry may be useful for subtyping ind…

Two-Color Dark-Adapted Perimetry Implemented With a Commercially Available Perimeter to Characterize Rod-Pathway Sensitivity Open

Austin D. Igelman, Jason C. Park, Robert A. Hyde, Lesley Everett, Paul Yang , et al. · 2022

Background and Objective: To characterize rod-pathway function across the visual field using 2-color dark-adapted perimetry (2cDAP) implemented with conventional Octopus 900 Pro perimeters. Patients and Methods: Eighteen visually normal in…

Spatial and Temporal Integration Abnormalities in X-Linked Retinoschisis Open

J. Jason McAnany, Jason C. Park, Gerald A. Fishman, Robert A. Hyde · 2022

Spatial and temporal integration characteristics of the XLRS fovea, parafovea, and perifovea are similar to those of the normal periphery. The results also indicate that scaling stimulus size equates thresholds for the XLRS and control sub…

Contrast Sensitivity and Equivalent Intrinsic Noise in X-Linked Retinoschisis Open

J. Jason McAnany, Jason C. Park, Gerald A. Fishman, Robert A. Hyde · 2022

Internal noise measurements can provide insight into a source of CS loss in some individuals with XLRS.

Effect of Pharmacological Pupil Dilation on Dark-Adapted Perimetric Sensitivity in Healthy Subjects Using an Octopus 900 Perimeter Open

Austin D. Igelman, Cristy A. Ku, Sam Mershon, Mariana Matioli da Palma, J. Jason McAnany , et al. · 2021

In this study, pharmacological dilation did not have a clinically meaningful effect on sensitivity, suggesting that this is not necessary when using two-color dark-adapted perimetry to assess for rod function.

Cone pathway dysfunction in Jalili syndrome due to a novel familial variant of <i>CNNM4</i> revealed by pupillometry and electrophysiologic investigations Open

Robert A. Hyde, Evelina Kratunova, Jason C. Park, J. Jason McAnany · 2021

CNNM4 variants can result in Jalili syndrome with cone dystrophy and generally preserved rod function. The PLR may be a useful measure for evaluating cone function in these individuals, as robust cone-mediated PLRs were recordable d…

Luminance Thresholds and Their Correlation With Retinal Structure in X-Linked Retinoschisis Open

J. Jason McAnany, Jason C. Park, Gerald A. Fishman, Robert A. Hyde · 2021

Threshold elevation in XLRS is complex, depending on both the adaptation level and the visual field location. The pattern of threshold-versus-illuminance suggests that macular function in XLRS is similar to the periphery of controls.

Chromatic Pupillometry in Isolated Rapid Eye Movement Sleep Behavior Disorder Open

Chiara La Morgia, Martina Romagnoli, Fabio Pizza, Francesco Biscarini, Marco Filardi , et al. · 2021

Background Melanopsin retinal ganglion cell (mRGC)‐mediated pupillary light reflex (PLR) abnormalities have been documented in several neurodegenerative disorders including Parkinson's disease. Overall, isolated rapid eye movement (REM) sl…

Clinical electroretinography in diabetic retinopathy: a review Open

J. Jason McAnany, Oksana Persidina, Jason C. Park · 2021

Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease Open

J. Jason McAnany, Nathanael Matei, Yifan Chen, Karen Liu, Jason C. Park , et al. · 2021

To characterize rod- and cone-pathway function in the 5xFAD mouse model of Alzheimer’s disease (AD) using the full-field electroretinogram (ERG). Dark-adapted (DA; rod-pathway) and light-adapted (LA; cone-pathway) ERGs were recorded from t…

Electrophysiological and Pupillometric Abnormalities in PROM1 Cone–Rod Dystrophy Open

Jason C. Park, Frederick T. Collison, Gerald A. Fishman, J. Jason McAnany · 2020

These data highlight the potential usefulness of pupillometry in cases where the ERG is non-detectable.

Chromatic Pupillometry Findings in Alzheimer’s Disease Open

Martina Romagnoli, Michelangelo Stanzani Maserati, Maddalena De Matteis, Sabina Capellari, Michele Carbonelli , et al. · 2020

Intrinsically photosensitive melanopsin retinal ganglion cells (mRGCs) are crucial for non-image forming functions of the eye, including the photoentrainment of circadian rhythms and the regulation of the pupillary light reflex (PLR). Chro…

Full-Field Electroretinography, Pupillometry, and Luminance Thresholds in X-Linked Retinoschisis Open

J. Jason McAnany, Jason C. Park, Gerald A. Fishman, Frederick T. Collison · 2020

The results indicate that the presumed bipolar cell dysfunction in XLRS, indicated by b-wave abnormalities, has complex downstream effects: Dark-adapted luminance threshold and maximum pupil responses are not significantly affected, but pu…

Inner-retina dysfunction in the 5xFAD mouse model of Alzheimer’s disease assessed by electroretinography Open

J. Jason McAnany, Nathanael Matei, Karen Liu, Jason C. Park, Mahnaz Shahidi · 2020

Rod-pathway pupil responses measured with luminance versus rod-isolating contrast stimuli Open

Jason C. Park, Dingcai Cao, J. Jason McAnany · 2020

Peripheral PERG sensitivity in early glaucoma is improved by a more comprehensive evaluation of the response waveform. Open

Giri Balasubramanian, Shresta Patangay, Jason C. Park, J. Jason McAnany, John R. Hetling · 2020

Correction: Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease Open

Angela J. Oh, Giulia Amore, William Sultan, Samuel Asanad, Jason C. Park , et al. · 2020

[This corrects the article DOI: 10.1371/journal.pone.0226197.].

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