Jason Charng
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View article: Anatomy- versus sensitivity-based loci preselection in detecting USH2A-retinopathy microperimetric progression
Anatomy- versus sensitivity-based loci preselection in detecting USH2A-retinopathy microperimetric progression Open
View article: Artificial intelligence techniques in inherited retinal diseases: a review
Artificial intelligence techniques in inherited retinal diseases: a review Open
Inherited retinal diseases (IRDs) are a diverse group of genetic disorders that lead to progressive vision loss and are a major cause of blindness in working-age adults. The complexity and heterogeneity of IRDs pose significant challenges …
View article: Impact of Image Complexity on the Segmentation of Ophthalmic Images Using Deep Learning Methods
Impact of Image Complexity on the Segmentation of Ophthalmic Images Using Deep Learning Methods Open
Advances in medical imaging segmentation using deep learning (DL) have facilitated the development of a wide range of models based on different architectures. For example, the U-Net has become one of the most widely used architectures in t…
View article: The effect of near work on the anterior eye and associations with myopia: a narrative review
The effect of near work on the anterior eye and associations with myopia: a narrative review Open
The global prevalence of myopia has increased significantly in recent decades, and it is anticipated that half the population of the world will be myopic by 2050. The dramatic increase in myopia cannot be explained solely by genetic factor…
View article: Evaluating ocular health in retinal gene therapies
Evaluating ocular health in retinal gene therapies Open
Inherited retinal disease (IRD) refers to a heterogeneous group of genetic eye disease that causes progressive vision loss and was once regarded untreatable. However, regulatory approval for Luxturna (voretigene neparvovec-rzyl) for patien…
View article: Multicenter Normative Data for Mesopic Microperimetry
Multicenter Normative Data for Mesopic Microperimetry Open
Normal variations in visual sensitivity on mesopic microperimetry can be effectively explained by a linear model that includes age and eccentricity. The dataset and a code vignette are provided for estimating normative values across a larg…
View article: Artificial intelligence techniques in inherited retinal diseases: A review
Artificial intelligence techniques in inherited retinal diseases: A review Open
Inherited retinal diseases (IRDs) are a diverse group of genetic disorders that lead to progressive vision loss and are a major cause of blindness in working-age adults. The complexity and heterogeneity of IRDs pose significant challenges …
View article: Censoring the Floor Effect in Long-Term Stargardt Disease Microperimetry Data Produces a Faster Rate of Decline
Censoring the Floor Effect in Long-Term Stargardt Disease Microperimetry Data Produces a Faster Rate of Decline Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Identifying the practice patterns of optometrists in providing falls prevention management: A mixed-methods systematic review protocol
Identifying the practice patterns of optometrists in providing falls prevention management: A mixed-methods systematic review protocol Open
Objective The objective of this systematic review is to synthesise the best available evidence for optometrists’ practice patterns in providing falls prevention management. Introduction Falls remain the main cause of injury-related hospita…
View article: Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review
Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review Open
Migraine is one of the world’s most debilitating disorders, and it has recently been shown that changes in the retina can be a potential biomarker for the disease. These changes can be detected by optical coherence tomography (OCT), which …
View article: Multicenter normative data for mesopic microperimetry
Multicenter normative data for mesopic microperimetry Open
Purpose To provide a large, multi-center normative dataset for the Macular Integrity Assessment (MAIA) microperimeter and compare the goodness-of-fit and prediction interval calibration-error for a panel of hill-of-vision models. Methods M…
View article: Nonlinear Reduction in Hyperautofluorescent Ring Area in Retinitis Pigmentosa
Nonlinear Reduction in Hyperautofluorescent Ring Area in Retinitis Pigmentosa Open
View article: Distribution of Axial Length in Australians of Different Age Groups, Ethnicities, and Refractive Errors
Distribution of Axial Length in Australians of Different Age Groups, Ethnicities, and Refractive Errors Open
The axial length of myopic eyes increases rapidly in childhood, and there is a minimal increase in the axial length in non-myopic eyes after 18 years of age.
View article: A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration
A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration Open
View article: L-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial)
L-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial) Open
Background Migraine is a common and distressing neurological condition characterised by recurrent throbbing headaches, nausea and heightened sensitivity to light and sound. Accumulating evidence suggests that cerebral arteries dilate durin…
View article: Microperimetry and Adaptive Optics Imaging Reveal Localized Functional and Structural Changes in Asymptomatic <i>RPGR</i> Mutation Carriers
Microperimetry and Adaptive Optics Imaging Reveal Localized Functional and Structural Changes in Asymptomatic <i>RPGR</i> Mutation Carriers Open
MP and AO imaging revealed early functional and structural changes in asymptomatic RPGR mutation carriers and should be considered in clinical assessment of these patients.
View article: WITHDRAWN: L-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial)
WITHDRAWN: L-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial) Open
Withdrawal Statement The authors have withdrawn this manuscript due to an error in data analysis that significantly affects the validity of the reported findings. Therefore, the authors do not wish this work to be cited as reference for th…
View article: Correcting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length
Correcting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length Open
Background To generate and validate a method to estimate axial length estimated (AL est ) from spherical equivalent (SE) and corneal curvature [keratometry (K)], and to determine if this AL est can replace actual axial length (AL act ) for…
View article: Prevalence of Toxoplasmic Retinochoroiditis in an Australian Adult Population
Prevalence of Toxoplasmic Retinochoroiditis in an Australian Adult Population Open
View article: Evaluating Distribution of Foveal Avascular Zone Parameters Corrected by Lateral Magnification and Their Associations with Retinal Thickness
Evaluating Distribution of Foveal Avascular Zone Parameters Corrected by Lateral Magnification and Their Associations with Retinal Thickness Open
View article: Localised relative scotoma in cuticular drusen
Localised relative scotoma in cuticular drusen Open
View article: Short-Term Parafoveal Cone Loss Despite Preserved Ellipsoid Zone in Rod Cone Dystrophy
Short-Term Parafoveal Cone Loss Despite Preserved Ellipsoid Zone in Rod Cone Dystrophy Open
CD and ICD may change prior to EZ span shortening in RCD.
View article: Conjunctival ultraviolet autofluorescence area decreases with age and sunglasses use
Conjunctival ultraviolet autofluorescence area decreases with age and sunglasses use Open
Background Conjunctival ultraviolet autofluorescence (CUVAF) is a method of detecting conjunctival damage related to ultraviolet radiation exposure. In cross-sectional studies, CUVAF area is positively associated with self-reported time sp…
View article: Correction: Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images
Correction: Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images Open
[This corrects the article DOI: 10.1371/journal.pgen.1009497.].
View article: Distribution and Classification of Peripapillary Retinal Nerve Fiber Layer Thickness in Healthy Young Adults
Distribution and Classification of Peripapillary Retinal Nerve Fiber Layer Thickness in Healthy Young Adults Open
This study provides an improved understanding of normal variation in RNFL thickness in young adults.
View article: Conjunctival ultraviolet autofluorescence area is predictive of pterygium onset in young adults
Conjunctival ultraviolet autofluorescence area is predictive of pterygium onset in young adults Open
View article: Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images
Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images Open
Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseases including glaucoma. We present the first large-scale genome-wide association study of inner retinal morpho…
View article: Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults
Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults Open
Thickness values presented in this article could be used as a normative reference for future studies on young adults and in clinical practice.
View article: Deep clinical phenotyping and gene expression analysis in a patient with <i>RCBTB1</i>-associated retinopathy
Deep clinical phenotyping and gene expression analysis in a patient with <i>RCBTB1</i>-associated retinopathy Open
Background: Mutations in the RCC1 and BTB domain-containing protein 1 (RCBTB1) gene have been implicated in a rare form of retinal dystrophy. Herein, we report the clinical features of a 45-year-old Singaporean-Chinese female…
View article: Deep learning segmentation of hyperautofluorescent fleck lesions in Stargardt disease
Deep learning segmentation of hyperautofluorescent fleck lesions in Stargardt disease Open