Jason D. Kang
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View article: Tailored Levofloxacin Incorporated Extracellular Matrix Nanoparticles for Pulmonary Infections
Tailored Levofloxacin Incorporated Extracellular Matrix Nanoparticles for Pulmonary Infections Open
Cystic fibrosis produces viscous mucus in the lung that increases bacterial invasion, causing persistent infections and subsequent inflammation. Pseudomonas aeruginosa and Staphylococcus aureus are two of the most common infections in cyst…
View article: An expanded metabolic pathway for androgen production by host-associated bacteria
An expanded metabolic pathway for androgen production by host-associated bacteria Open
A growing body of literature implicates host-associated microbiota in the modulation of circulating androgen levels in the host, which could have far-reaching implications for androgen-mediated diseases. However, the microbial genetic path…
View article: Hepatic Branch Vagotomy Modulates the Gut-Liver-Brain Axis in Murine Cirrhosis
Hepatic Branch Vagotomy Modulates the Gut-Liver-Brain Axis in Murine Cirrhosis Open
Background Cirrhosis and hepatic encephalopathy (HE) are linked with an altered gut-liver-brain axis, however, the relative contribution of hepatic vagal innervation is unclear. We aimed to determine the impact of hepatic vagotomy on the g…
View article: Neuroinflammation in Murine Cirrhosis Is Dependent on the Gut Microbiome and Is Attenuated by Fecal Transplant
Neuroinflammation in Murine Cirrhosis Is Dependent on the Gut Microbiome and Is Attenuated by Fecal Transplant Open
Cirrhosis and hepatic encephalopathy (HE) is associated with an altered gut–liver–brain axis. Fecal microbial transplant (FMT) after antibiotics improves outcomes in HE, but the impact on brain function is unclear. The aim of this study is…
View article: Effect of Increasing Age on Brain Dysfunction in Cirrhosis
Effect of Increasing Age on Brain Dysfunction in Cirrhosis Open
Patients with cirrhosis are growing older, which could have an impact on brain dysfunction beyond hepatic encephalopathy. Our aim was to study the effect of concomitant aging and cirrhosis on brain inflammation and degeneration using human…