David W. Kaczka
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View article: Computationally-directed mechanical ventilation in a porcine model of ARDS
Computationally-directed mechanical ventilation in a porcine model of ARDS Open
Background Despite the implementation of protective mechanical ventilation, ventilator-induced lung injury remains a significant driver of ARDS-associated morbidity and mortality. Mechanical ventilation must be personalized and adaptive fo…
View article: Virtual patient model for evaluating automated inspired oxygen control
Virtual patient model for evaluating automated inspired oxygen control Open
Physiologic closed-loop control (PCLC) of inspired oxygen during mechanical ventilation involves frequent adjustment of inspired oxygen fraction (FiO2) based on feedback from monitoring peripheral oxygen saturation (S…
View article: Structural and functional characteristics of healthy and injured porcine lungs during deflation: a quantitative CT imaging analysis
Structural and functional characteristics of healthy and injured porcine lungs during deflation: a quantitative CT imaging analysis Open
We noted that quantitative computed tomographic (qCT) imaging has potential applications for assessing the severity of regional injury in the lung by providing detailed information on pressure-volume characteristics, distensibility, aerati…
View article: Assessment of ventilation heterogeneity and particle deposition in asthmatics using combined SPECT/CT imaging and computational modeling approaches
Assessment of ventilation heterogeneity and particle deposition in asthmatics using combined SPECT/CT imaging and computational modeling approaches Open
Our cluster-informed CFPD-based approach enhances the understanding of ventilation heterogeneity in asthma and holds potential for refining strategies for inhalational therapies.
View article: Correction: Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation
Correction: Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation Open
View article: Forward Computational Modeling of Respiratory Airflow
Forward Computational Modeling of Respiratory Airflow Open
The simulation of gas flow in the bronchial tree using computational fluid dynamics (CFD) has become a useful tool for the analysis of gas flow mechanics, structural deformation, ventilation, and particle deposition for drug delivery durin…
View article: Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation
Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation Open
These findings support the hypothesis that sufficiently short expiratory durations protect against atelectrauma because they do not give derecruitment enough time to manifest. This suggests a means for the personalized adjustment of mechan…
View article: Imaging the Lung in ARDS: A Primer
Imaging the Lung in ARDS: A Primer Open
Despite periodic changes in the clinical definition of ARDS, imaging of the lung remains a central component of its diagnostic identification. Several imaging modalities are available to the clinician to establish a diagnosis of the syndro…
View article: Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection
Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection Open
Acute respiratory distress syndrome (ARDS) alters the dynamics of lung inflation during mechanical ventilation. Repetitive alveolar collapse and expansion (RACE) predisposes the lung to ventilator-induced lung injury (VILI). Two broad appr…
View article: Sustained vs. Intratidal Recruitment in the Injured Lung During Airway Pressure Release Ventilation: A Computational Modeling Perspective
Sustained vs. Intratidal Recruitment in the Injured Lung During Airway Pressure Release Ventilation: A Computational Modeling Perspective Open
Introduction During mechanical ventilation, cyclic recruitment and derecruitment (R/D) of alveoli result in focal points of heterogeneous stress throughout the lung. In the acutely injured lung, the rates at which alveoli can be recruited …
View article: Ratchet recruitment in the acute respiratory distress syndrome: lessons from the newborn cry
Ratchet recruitment in the acute respiratory distress syndrome: lessons from the newborn cry Open
Patients with acute respiratory distress syndrome (ARDS) have few treatment options other than supportive mechanical ventilation. The mortality associated with ARDS remains unacceptably high, and mechanical ventilation itself has the poten…
View article: Mechanical Power and Ventilator-induced Lung Injury: What Does Physics Have to Say?
Mechanical Power and Ventilator-induced Lung Injury: What Does Physics Have to Say? Open
"Mechanical Power and Ventilator-induced Lung Injury: What Does Physics Have to Say?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: First Stabilize and then Gradually Recruit: A Paradigm Shift in Protective Mechanical Ventilation for Acute Lung Injury
First Stabilize and then Gradually Recruit: A Paradigm Shift in Protective Mechanical Ventilation for Acute Lung Injury Open
Acute respiratory distress syndrome (ARDS) is associated with a heterogeneous pattern of injury throughout the lung parenchyma that alters regional alveolar opening and collapse time constants. Such heterogeneity leads to atelectasis and r…
View article: Positron Emission Tomography-Computed Tomography Imaging of Selective Lobar Delivery of Stem Cells in <i>Ex Vivo</i> Lung Model of Mechanical Ventilation
Positron Emission Tomography-Computed Tomography Imaging of Selective Lobar Delivery of Stem Cells in <i>Ex Vivo</i> Lung Model of Mechanical Ventilation Open
Introduction: The delivery of cell therapies may be an important frontier to treat different respiratory diseases in the near future. However, the cell size, delivery conditions, cell viability, and effect in the pulmonary fu…
View article: Unshrinking the baby lung to calm the VILI vortex
Unshrinking the baby lung to calm the VILI vortex Open
View article: Pulmonary Blood Volume Among Older Adults in the Community: The MESA Lung Study
Pulmonary Blood Volume Among Older Adults in the Community: The MESA Lung Study Open
Background: The pulmonary vasculature is essential for gas exchange and impacts both pulmonary and cardiac function. However, it is difficult to assess and its characteristics in the general population are unknown. We measured pulmonary bl…
View article: Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies
Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies Open
The mammalian lung is characterized by heterogeneity in both its structure and function, by incorporating an asymmetric branching airway tree optimized for maintenance of efficient ventilation, perfusion, and gas exchange. Despite potentia…
View article: Clinical significance and applications of oscillometry
Clinical significance and applications of oscillometry Open
Recently, “Technical standards for respiratory oscillometry” was published, which reviewed the physiological basis of oscillometric measures and detailed the technical factors related to equipment and test performance, quality assurance an…
View article: Correction to: A comparison of endotracheal tube compensation technique for the measurement of respiratory mechanical impedance at low frequencies
Correction to: A comparison of endotracheal tube compensation technique for the measurement of respiratory mechanical impedance at low frequencies Open
View article: A comparison of endotracheal tube compensation techniques for the measurement of respiratory mechanical impedance at low frequencies
A comparison of endotracheal tube compensation techniques for the measurement of respiratory mechanical impedance at low frequencies Open
View article: Effects of Lung Injury on Regional Aeration and Expiratory Time Constants: Insights From Four-Dimensional Computed Tomography Image Registration
Effects of Lung Injury on Regional Aeration and Expiratory Time Constants: Insights From Four-Dimensional Computed Tomography Image Registration Open
Rationale : Intratidal changes in regional lung aeration, as assessed with dynamic four-dimensional computed tomography (CT; 4DCT), may indicate the processes of recruitment and derecruitment, thus portending atelectrauma during mechanical…
View article: Case Studies in Physiology: Temporal variations of the lung parenchyma and vasculature in asymptomatic COVID-19 pneumonia: a multispectral CT assessment
Case Studies in Physiology: Temporal variations of the lung parenchyma and vasculature in asymptomatic COVID-19 pneumonia: a multispectral CT assessment Open
We characterized the temporal changes of lung parenchyma and microvascular pathophysiology from COVID-19 infection in an asymptomatic young, healthy nonsmoking male using dual-energy CT. Lung parenchymal mechanics and microvascular disease…
View article: Recursive Refinement Network for Deformable Lung Registration between Exhale and Inhale CT Scans
Recursive Refinement Network for Deformable Lung Registration between Exhale and Inhale CT Scans Open
Unsupervised learning-based medical image registration approaches have witnessed rapid development in recent years. We propose to revisit a commonly ignored while simple and well-established principle: recursive refinement of deformation v…
View article: Regional Gas Transport During Conventional and Oscillatory Ventilation Assessed by Xenon-Enhanced Computed Tomography
Regional Gas Transport During Conventional and Oscillatory Ventilation Assessed by Xenon-Enhanced Computed Tomography Open
View article: Contribution of the Chest-Wall to Changes in the Respiratory System Elastance During a Decremental PEEP Titration in Sheep With and Without Lung Injury
Contribution of the Chest-Wall to Changes in the Respiratory System Elastance During a Decremental PEEP Titration in Sheep With and Without Lung Injury Open
View article: Personalized Pressure-Volume Curve of the Lung Through CT-Based Network Modeling
Personalized Pressure-Volume Curve of the Lung Through CT-Based Network Modeling Open
View article: Non-Linear Inflation Dynamics Increase During Progression of Experimental Lung Injury
Non-Linear Inflation Dynamics Increase During Progression of Experimental Lung Injury Open
Rationale: Heterogeneous kinetics of inflation indicate abnormal regional lung mechanics and potentially, areas of lung tissue at risk of lung injury progression during poorly-protective mechanical ventilation.These characteristics may evo…
View article: Quality Control for Quantitation of Regional Pulmonary Perfused Blood Volume via Dual-Energy CT Scanning in a Large Multi-Center Cohort: The MESA Lung Study
Quality Control for Quantitation of Regional Pulmonary Perfused Blood Volume via Dual-Energy CT Scanning in a Large Multi-Center Cohort: The MESA Lung Study Open
View article: Pulmonary Blood Volume in Older Adults Assessed by Dual-Energy Computed Tomography: The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study
Pulmonary Blood Volume in Older Adults Assessed by Dual-Energy Computed Tomography: The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study Open
Rationale The pulmonary vasculature is critical for gas exchange, impacts both pulmonary and cardiac function, and has renewed importance due to COVID-19. Pulmonary blood volume is, however, technically difficult to assess, generally requi…
View article: Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome
Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome Open