Explanipedia

Lymphoid gene expression supports neuroprotective microglia function Open

Pinar Ayata, John Crowley, Matthew F. Challman, Vinaya Sahasrabuddhe, Maud Gratuze , et al. · 2025

Microglia, the innate immune cells of the brain, play a defining role in the progression of Alzheimer’s disease (AD) 1 . The microglial response to amyloid plaques in AD can range from neuroprotective to neurotoxic 2 . Here we show that th…

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease Open

Matthew P. Lennol, Chiara Bordier, Léana Kamelher, Jason D. Ulrich, David M. Holtzman , et al. · 2025

Alzheimer’s disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles. While much of the research ha…

APOE3 Christchurch influences amyloid induced tau seeding and spreading via effects on microglia Open

Yun Chen, Sihui Song, Samira Parhizkar, Jennifer Lord, Yiyang Zhu , et al. · 2024

Background A recent case report described an individual who was a homozygous carrier of the APOE3 Christchurch (APOE3ch) mutation and resistant to autosomal dominant Alzheimer’s Disease (AD) caused by a PSEN1‐E280A mutation. Whether APOE3c…

Investigation of Tau as a self‐antigen that drives T cell immunity in a tauopathy mouse model Open

Hao Hu, Jason D. Ulrich, David M. Holtzman · 2024

Background Alzheimer’s disease (AD) is characterized by the aggregation and accumulation of proteins including amyloid‐β and tau. We previously compared the immunological milieus in the brain of mice with amyloid deposition or tau aggregat…

CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly Open

Francis Shue, Launia J. White, Rachel Hendrix, Jason D. Ulrich, Rachel L. Henson , et al. · 2024

Background The immune system is substantially involved in the development and progression of age‐related cognitive decline and Alzheimer’s disease (AD). Method As genetic and environmental factors interactively impact these conditions, we …

CSF biomarkers of immune activation and Alzheimer’s disease for predicting cognitive impairment risk in the elderly Open

Francis Shue, Launia J. White, Rachel Hendrix, Jason D. Ulrich, Rachel L. Henson , et al. · 2024

Background The immune system is substantially involved in the development and progression of age‐related cognitive decline and Alzheimer’s disease (AD). Method As genetic and environmental factors interactively impact these conditions, we …

Author Correction: Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy Open

Xiaoying Chen, Maria Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov , et al. · 2024

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference Open

Courtney M. Kloske, Michaël E. Belloy, Elizabeth Blue, Gregory R. Bowman, María C. Carrillo , et al. · 2024

INTRODUCTION The apolipoprotein E gene ( APOE ) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid‐beta and tau pathologi…

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist Open

Alexandra Litvinchuk, Jung H. Suh, Jing Guo, Karin Lin, Sonnet S. Davis , et al. · 2024

Rapid sequential clustering of NMDARs, CaMKII, and AMPARs upon activation of NMDARs at developing synapses Open

Yucui Chen, Shangming Liu, Ariel A. Jacobi, Grace Jeng, Jason D. Ulrich , et al. · 2024

Rapid, synapse-specific neurotransmission requires the precise alignment of presynaptic neurotransmitter release and postsynaptic receptors. How postsynaptic glutamate receptor accumulation is induced during maturation is not well understo…

CSF biomarkers of immune activation and Alzheimer’s disease for predicting cognitive impairment risk in the elderly Open

Francis Shue, Launia J. White, Rachel Hendrix, Jason D. Ulrich, Rachel L. Henson , et al. · 2024

The immune system substantially influences age-related cognitive decline and Alzheimer’s disease (AD) progression, affected by genetic and environmental factors. In a Mayo Clinic Study of Aging cohort, we examined how risk factors like APO…

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy Open

Danira Toral-Ríos, Justin M. Long, Jason D. Ulrich, Jinsheng Yu, Michael R. Strickland , et al. · 2024

Alzheimer’s disease (AD) is characterized by amyloid plaques and neurofibrillary tangles, in addition to neuroinflammation and changes in brain lipid metabolism. 25-Hydroxycholesterol (25-HC), a known modulator of both inflammation and lip…

APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread Open

Yun Chen, Sihui Song, Samira Parhizkar, Jennifer Lord, Yiyang Zhu , et al. · 2023

Microglia‐mediated T cell Infiltration Drives Neurodegeneration in Tauopathy Open

Xiaoying Chen, Maria Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov , et al. · 2023

Background Extracellular amyloid‐β (Aβ) deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau as neurofibrillary tangles (NFT) are two of the characteristic hallmarks in Alzheimer’s disease (A…

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist Open

Alexandra Litvinchuk, Jung H. Suh, Jing Guo, Karin Lin, Sonnet S. Davis , et al. · 2023

IMMU-28. TREM2 INHIBITION REPROGRAMS MYELOID CELLS TO STIMULATE ANTI-TUMOR IMMUNITY THROUGH BOTH DIRECT AND INDIRECT MECHANISMS Open

Rui Sun, Rowland H. Han, Colin McCornack, G. Travis Tabor, Jinchao Hou , et al. · 2023

The prevailing view is that myeloid cells—macrophages and microglia—in the tumor microenvironment (TME) are immunosuppressive and promote glioblastoma (GBM) progression. However, myeloid cells have the functional plasticity to restrict or …

Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration Open

Antoine Drieu, Siling Du, Michal Kipnis, Megan E. Bosch, Jasmin Herz , et al. · 2023

Parenchymal border macrophages (PBMs) reside close to the central nervous system parenchyma and regulate CSF flow dynamics. We recently demonstrated that PBMs provide a clearance pathway for amyloid-β peptide, which accumulates in the brai…

APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading Open

Chanung Wang, Aishwarya Nambiar, Michael R. Strickland, Choonghee Lee, Samira Parhizkar , et al. · 2023

Alzheimer's disease (AD) is the most common cause of dementia. The APOE-ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD. The APOE genotype modulates the effect of sleep disruption on AD …

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma Open

Rui Sun, Rowland H. Han, Colin McCornack, Saad M. Khan, G. Travis Tabor , et al. · 2023

Triggering receptor expressed on myeloid cells 2 (TREM2) plays important roles in brain microglial function in neurodegenerative diseases, but the role of TREM2 in the GBM TME has not been examined. Here, we found that TREM2 is highly expr…

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy Open

Xiaoying Chen, Maria Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov , et al. · 2023

Microglia-mediated T cell Infiltration Drives Neurodegeneration in Tauopathy Open

Xiaoying Chen, Ekaterina Aladyeva, Maria Firulyova, Maxim N. Artyomov, Jason D. Ulrich , et al. · 2023

Extracellular amyloid-β (Aβ) deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau as neurofibrillary tangles (NFT) are two of the characteristic hallmarks in Alzheimer’s disease (AD). The reg…

Microglia-mediated T cell Infiltration Drives Neurodegeneration in Tauopathy Open

Xiaoying Chen, Ekaterina Aladyeva, Maria Firulyova, Maxim N. Artyomov, Jason D. Ulrich , et al. · 2023

Extracellular amyloid-β (Aβ) deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau as neurofibrillary tangles (NFT) are two of the characteristic hallmarks in Alzheimer’s disease (AD). The reg…

ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy Open

Dong-oh Seo, David O’Donnell, Nimansha Jain, Jason D. Ulrich, Jasmin Herz , et al. · 2023

Tau-mediated neurodegeneration is a hallmark of Alzheimer’s disease. Primary tauopathies are characterized by pathological tau accumulation and neuronal and synaptic loss. Apolipoprotein E (ApoE)–mediated neuroinflammation is involved in t…

TREM2 and microglia exosomes: a potential highway for pathological tau Open

Nimansha Jain, Jason D. Ulrich · 2022

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4 Open

Maud Gratuze, Johannes C. M. Schlachetzki, Ricardo D’Oliveira Albanus, Nimansha Jain, Brenna C. Novotny , et al. · 2022

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading Open

Nimansha Jain, Caroline A. Lewis, Jason D. Ulrich, David M. Holtzman · 2022

Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene are associated with increased risk for late-onset AD. Genetic loss of or decreased TREM2 function impairs the microglial response to amyloid-β (Aβ) plaques, resu…

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis Open

Thomas E. Mahan, Chao Wang, Xin Bao, Ankit Choudhury, Jason D. Ulrich , et al. · 2022

Neuronal VCP loss of function recapitulates FTLD-TDP pathology Open

Abubakar Wani, Jiang Zhu, Jason D. Ulrich, Abdallah M. Eteleeb, Andrew D. Sauerbeck , et al. · 2021

The pathogenic mechanism by which dominant mutations in VCP cause multisystem proteinopathy (MSP), a rare neurodegenerative disease that presents as fronto-temporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), remains unclear. To …

Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms Open

Yang Shi, Prabhakar S. Andhey, Christina Ising, Kairuo Wang, Lisa L. Snipes , et al. · 2021

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation Open

Deepti Lall, Ileana Lorenzini, Thomas A. Mota, Shaughn Bell, Thomas E. Mahan , et al. · 2021

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