Explanipedia

Access to Allogeneic Cell Transplantation Based on Donor Search Prognosis: An Interventional Trial Open

Jason Dehn, Brent R. Logan, Bronwen E. Shaw, Steven M. Devine, Stefan O. Ciurea , et al. · 2024

Importance Patients requiring allogeneic hematopoietic cell transplantation have variable likelihoods of identifying an 8/8 HLA-matched unrelated donor. A Search Prognosis calculator can estimate the likelihood. Objective To determine if u…

Survival Improvements in Adolescents and Young Adults after Myeloablative Allogeneic Transplantation for Acute Lymphoblastic Leukemia Open

William A. Wood, Stephanie J. Lee, Ruta Brazauskas, Zhiwei Wang, Mahmoud Aljurf , et al. · 2020

Adolescents and young adults (AYAs, ages 15–40 years) with cancer have not experienced survival improvements to the same extent as younger and older patients. We compared changes in survival following myeloablative allogeneic hematopoietic…

Likelihood of Proceeding to Allogeneic Hematopoietic Cell Transplantation in the United States after Search Activation in the National Registry: Impact of Patient Age, Disease, and Search Prognosis Open

Jason Dehn, Pintip Chitphakdithai, Bronwen E. Shaw, Abby A. McDonald, Steven M. Devine , et al. · 2020

The National Marrow Donor Program (NMDP) operates the Be The Match Registry to serve patients who require an allogeneic hematopoietic cell transplant (alloHCT). The factors that result in progression of an active donor search (ie, request …

Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0 Open

Carolyn Katovich Hurley, Jane Kempenich, Kim Wadsworth, Jürgen Sauter, Jan A. Hofmann , et al. · 2020

A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell voluntee…

Urgent Time to Allogeneic Hematopoietic Cell Transplantation: A National Survey of Transplant Physicians and Unrelated Donor Search Coordinators Facilitated by the Histocompatibility Advisory Group to the National Marrow Donor Program Open

Joseph Pidala, Tatenda Mupfudze, Tammy Payton, Juliet N. Barker, Miguel‐Angel Perales , et al. · 2019

To characterize donor search and selection practices, the National Marrow Donor Program (NMDP) Histocompatibility Advisory Group developed a survey of allogeneic hematopoietic cell transplant (HCT) physicians and search coordinators. The o…

Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR Open

Jason Dehn, Stephen R. Spellman, Carolyn Katovich Hurley, Bronwen E. Shaw, Juliet N. Barker , et al. · 2019

This Special Report, this month’s CME article, details evidence-based guidelines for the selection of optimal unrelated donors and cord blood units for allogeneic hematopoietic cell transplantation.

Regarding “Recipients Receiving Better HLA-Matched Hematopoietic Cell Transplantation Grafts, Uncovered by a Novel HLA Typing Method, Have Superior Survival: A Retrospective Study” Open

Carolyn Katovich Hurley, Stephen R. Spellman, Jason Dehn, Juliet N. Barker, Steven M. Devine , et al. · 2019

The retrospective study by Mayor et al. [1Mayor N.P. Hayhurst J.D. Turner T.R. et al.Recipients receiving better HLA-matched hematopoietic cell transplantation grafts, uncovered by a novel HLA typing method, have superior survival: a retro…

CD34+ cell content of 126 341 cord blood units in the US inventory: implications for transplantation and banking Open

Juliet N. Barker, Jane Kempenich, Joanne Kurtzberg, Claudio G. Brunstein, Colleen Delaney , et al. · 2019

CD34+ cell dose is critical for cord blood (CB) engraftment. However, the CD34+ content of the CB inventory in the United States is unknown. We examined the CD34+ cell content of 126 341 red blood cell–depleted US units banked from January…

What Defines an Urgent Time to Transplant (TtT)? a National Marrow Donor Program (NMDP) Survey of Transplant Physicians and Search Coordinators’ Unrelated Donor Selection Practices Open

Joseph A. Pidala, Tatenda Mupfudze, Tammy Payton, Juliet N. Barker, Miguel‐Angel Perales , et al. · 2019

IntroductionUnrelated donor search and selection practices by hematopoietic cell transplant (HCT) physicians and search coordinators are not standardized across centers, and what defines urgent TtT is not well understood.ObjectiveTo evalua…

NMDP Expedited Search Process: Selection, Typing and Transplant (STaT) Open

Gretta L. Stritesky, Kimberly Wadsworth, Brianna Springer, Kelly Buck, Erjeta Toska , et al. · 2019

AimsPatients transplanted earlier in their disease have better outcomes. Haploidentical transplants continue to increase in part due to the time in finding a donor and cost associated with unrelated donor transplant. We aimed to determine …

Development of an Unrelated Donor Selection Score Predictive of Survival after HCT: Donor Age Matters Most Open

Bronwen E. Shaw, Brent R. Logan, Stephen R. Spellman, Steven G. E. Marsh, James Robinson , et al. · 2018

Donor factors, in addition to HLA matching status, have been associated with recipient survival in unrelated donor (URD) hematopoietic cell transplantation (HCT); however, there is no hierarchical algorithm that weights the characteristics…

Analysis of the CD34+ Cell Content of 126, 341 Cord Blood (CB) Units in the NMDP be the Match Inventory: Implications for CB Transplantation and Public Banking Open

Juliet N. Barker, Jane Kempenich, Merry Duffy, Claudio G. Brunstein, Colleen Delaney , et al. · 2018

Background: Infused CD34+ cell dose is a critical determinant of the speed & success of engraftment after single & double unit CBT, & analyses have demonstrated that the cryopreserved CD34+ cell dose can reliably predict the post-thaw CD34…

Identification of Unrelated Donors with Minimal Low Expression Level HLA Allele Mismatches Open

Kimberly Wadsworth, Jennifer Novakovich, Kelly Buck, Jason Dehn · 2017

Background: Previous studies have suggested that matching at loci beyond highly expressed HLA-A, -B, -C, and -DRB1 should be considered to improve transplant outcomes. When transplanting with a 7/8 donor, ≥3 mismatches in the low expressio…

The effect of inter-unit HLA matching in double umbilical cord blood transplantation for acute leukemia Open

Claudio G. Brunstein, Mei-Jie Zhang, Juliet N. Barker, Andrew St. Martin, Asad Bashey , et al. · 2017

The effects of inter-unit HLA-match on early outcomes with regards to double cord blood transplantation have not been established. Therefore, we studied the effect of inter-unit HLA-mismatching on the outcomes of 449 patients with acute le…

Identification of DPB1 Permissive Unrelated Donors Is Highly Likely Open

Kevin Tram, Gretta L. Stritesky, Kim Wadsworth, Jennifer Ng, Claudio Anasetti , et al. · 2016

HLA-DPB1 permissive matching based on T cell epitope (TCE) groups should be considered when selecting among equally matched HLA-A, -B, -C, -DRB1 unrelated hematopoietic stem cell donors to improve patient survival. Previous studies have de…

HapLogic: A Predictive Human Leukocyte Antigen–Matching Algorithm to Enhance Rapid Identification of the Optimal Unrelated Hematopoietic Stem Cell Sources for Transplantation Open

Jason Dehn, Michelle Setterholm, Kelly Buck, Jane Kempenich, Beth Beduhn , et al. · 2016

The search for a suitable human leukocyte antigen (HLA)-matched unrelated adult stem cell donor (URD) or umbilical cord blood unit (UCB) is a complex process. The National Marrow Donor Program (NMDP) developed a search algorithm known as H…

High-Resolution Match Rate of 7/8 and 9/10 or Better for the Be The Match Unrelated Donor Registry Open

Kelly Buck, Kim Wadsworth, Michelle Setterholm, Martin Maiers, Dennis L. Confer , et al. · 2015

Estimation of the National Marrow Donor Program's Be The Match Registry 8/8 (HLA-A, -B, -C, and -DRB1) high-resolution (HR) unrelated donor (URD) match rate was determined in a prior study for each of the 4 most frequent patient race/ethni…

Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation Open

Ronald Sobecks, Tao Wang, Medhat Askar, Meighan M. Gallagher, Michael Haagenson , et al. · 2015

Natural killer cells are regulated by killer cell immunoglobulin-like receptor (KIR) interactions with HLA class I ligands. Several models of natural killer cell reactivity have been associated with improved outcomes after myeloablative al…

Selection of DPB1 T-Cell Epitope Permissive Matching Likely for Patients with 10/10 Unrelated Donors Open

Kevin Tram, Gretta L. Stritesky, Kimberly Wadsworth, Deidre M. Kiefer, Jennifer Ng , et al. · 2015

Recent research suggests that beyond 8/8 allele level matching at HLA-A, B, C, DRB1, matching at HLA-DPB1 should be considered to improve patient survival rates in allogeneic stem cell transplantation. DPB1 alleles have been separated into…

Registry Efforts to Improve Success of Unrelated Donor Searching for African American Patients Open

Katie Howe, Kevin Tram, Beth Beduhn, Rachel Fonstad, Deidre M. Kiefer , et al. · 2015

African American (AFA) patients are an underserved race group in bone marrow transplant due to their diverse HLA, limited number of potential unrelated donors (URD) and low URD availability rates. Newly entered AFA patients who had Be The …

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