Jason L. Scragg
YOU?
Author Swipe
View article: Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice
Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice Open
View article: JoVE Video Dataset
JoVE Video Dataset Open
Microvascular endothelial cells (MVECs) have many critical roles, including control of vascular tone, regulation of thrombosis, and angiogenesis. Significant heterogeneity in endothelial cell (EC) genotype and phenotype depends on their va…
View article: Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling
Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling Open
The voltage-gated K + channel plays a key role in atrial excitability, conducting the ultra-rapid rectifier K + current (I Kur ) and contributing to the repolarization of the atrial action potential. In this study, we examine its regulatio…
View article: Paracrine role for endothelial IGF-1 receptor in white adipocyte beiging
Paracrine role for endothelial IGF-1 receptor in white adipocyte beiging Open
Summary There are at least two distinct types of thermogenic adipocyte in mammals: a pre-existing form established during development, termed classical brown adipocytes and an inducible form, ‘beige’ adipocytes 1–3 . Various environmental …
View article: Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1
Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1 Open
View article: Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism
Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism Open
View article: Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis Open
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network…
View article: Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy
Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy Open
Background People with chronic heart failure (CHF) experience severe skeletal muscle dysfunction, characterized by mitochondrial abnormalities, which exacerbates the primary symptom of exercise intolerance. However, the molecular triggers …
View article: Brown and beige adipose tissue regulate systemic metabolism to resist diet-induced obesity through metabolite signals in an inter-organ signaling axis
Brown and beige adipose tissue regulate systemic metabolism to resist diet-induced obesity through metabolite signals in an inter-organ signaling axis Open
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an inter-organ signaling networ…
View article: Piezo1 channel activation mimics high glucose as a stimulator of insulin release
Piezo1 channel activation mimics high glucose as a stimulator of insulin release Open
View article: Piezo1 channel agonist mimics high glucose as a stimulator of insulin release
Piezo1 channel agonist mimics high glucose as a stimulator of insulin release Open
Objective Glucose and hypotonicity induced cell swelling stimulate insulin release from pancreatic β-cells but the mechanisms are poorly understood. Recently, Piezo1 was identified as a mechanically-activated nonselective Ca 2+ permeable c…
View article: Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K+ channel Kv1.5
Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K+ channel Kv1.5 Open
View article: A key role for peroxynitrite‐mediated inhibition of cardiac ERG (Kv11.1) K <sup>+</sup> channels in carbon monoxide–induced proarrhythmic early afterdepolarizations
A key role for peroxynitrite‐mediated inhibition of cardiac ERG (Kv11.1) K <sup>+</sup> channels in carbon monoxide–induced proarrhythmic early afterdepolarizations Open
Exposure to CO causes early afterdepolarization arrhythmias. Previous studies in rats have indicated that arrhythmias arose as a result of augmentation of the late Na + current. The purpose of the present study was to examine the basis for…
View article: Heme oxygenase-1 derived carbon monoxide suppresses Aβ1–42 toxicity in astrocytes
Heme oxygenase-1 derived carbon monoxide suppresses Aβ1–42 toxicity in astrocytes Open
View article: Redox-Dependent Modulation of T-Type Ca<sup>2+</sup> Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P
Redox-Dependent Modulation of T-Type Ca<sup>2+</sup> Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P Open
SP modulates T-type channel activity in nociceptors by a redox-dependent tuning of channel sensitivity to zinc; this novel modulatory pathway contributes to the peripheral anti-nociceptive effect of SP. Antioxid. Redox Signal. 25, 233-251.
View article: Regulation of the T‐type Ca<sup>2+</sup>channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H<sub>2</sub>S in nociception
Regulation of the T‐type Ca<sup>2+</sup>channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H<sub>2</sub>S in nociception Open
Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide. Indeed, many of the biological actions of these gas…