Jason M. Doherty
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View article: Treatment Patterns and Survival Among Veterans With De Novo Metastatic Hormone-Sensitive Prostate Cancer
Treatment Patterns and Survival Among Veterans With De Novo Metastatic Hormone-Sensitive Prostate Cancer Open
Importance Combination therapy for metastatic hormone-sensitive prostate cancer (mHSPC) has been widely adopted, yet clinical use and outcomes are unknown. Furthermore, optimal therapy is uncertain due to lack of direct comparison of andro…
View article: Cohort profile: The Scottish SHARE Mental Health (SHARE-MH) cohort – linkable survey, genetic and routinely collected data for mental health research
Cohort profile: The Scottish SHARE Mental Health (SHARE-MH) cohort – linkable survey, genetic and routinely collected data for mental health research Open
Purpose The SHARE Mental Health (SHARE-MH) cohort was established to address the paucity of clinical and genetic data available for mental health research. The cohort brings together detailed mental health questionnaire responses, routinel…
View article: 58 Cognitive and Brain Reserve Predict a Decline in Adverse Driving Behaviors Among Cognitively Normal Older Adults
58 Cognitive and Brain Reserve Predict a Decline in Adverse Driving Behaviors Among Cognitively Normal Older Adults Open
Objective: Daily driving behavior is ultimate measure of cognitive functioning requiring multiple cognitive domains working synergistically to complete this complex instrumental activity of daily living. As the world’s population continues…
View article: Medication and Road Test Performance Among Cognitively Healthy Older Adults
Medication and Road Test Performance Among Cognitively Healthy Older Adults Open
Importance Older adults are increasingly prescribed medications that have adverse effects. Prior studies have found a higher risk of motor vehicle crashes to be associated with certain medication use. Objective To determine whether specifi…
View article: Differential impacts of road diets on driving behavior among older adults with and without preclinical Alzheimer’s pathology
Differential impacts of road diets on driving behavior among older adults with and without preclinical Alzheimer’s pathology Open
View article: Neuropsychiatric Symptoms and Alzheimer Disease Biomarkers Independently Predict Progression to Incident Cognitive Impairment
Neuropsychiatric Symptoms and Alzheimer Disease Biomarkers Independently Predict Progression to Incident Cognitive Impairment Open
View article: Data from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
Data from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth Open
Alterations in the tissue microenvironment collaborate with cell autonomous genetic changes to contribute to neoplastic progression. The importance of the microenvironment in neoplastic progression is underscored by studies showing that fi…
View article: Data from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
Data from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth Open
Alterations in the tissue microenvironment collaborate with cell autonomous genetic changes to contribute to neoplastic progression. The importance of the microenvironment in neoplastic progression is underscored by studies showing that fi…
View article: Supplementary Figure 2 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
Supplementary Figure 2 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth Open
Supplementary Figure 2 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
View article: Supplementary Figure 1 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
Supplementary Figure 1 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth Open
Supplementary Figure 1 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
View article: Supplementary Figure 1 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
Supplementary Figure 1 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth Open
Supplementary Figure 1 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
View article: Supplementary Figure 3 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
Supplementary Figure 3 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth Open
Supplementary Figure 3 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
View article: Supplementary Figure 3 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
Supplementary Figure 3 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth Open
Supplementary Figure 3 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
View article: Supplementary Figure 2 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
Supplementary Figure 2 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth Open
Supplementary Figure 2 from Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
View article: Cortical atrophy and leukoaraiosis, imaging markers of cerebrovascular small vessel disease, are associated with driving behavior changes among cognitively normal older adults
Cortical atrophy and leukoaraiosis, imaging markers of cerebrovascular small vessel disease, are associated with driving behavior changes among cognitively normal older adults Open
View article: Everyday Driving and Plasma Biomarkers in Alzheimer’s Disease: Leveraging Artificial Intelligence to Expand Our Diagnostic Toolkit
Everyday Driving and Plasma Biomarkers in Alzheimer’s Disease: Leveraging Artificial Intelligence to Expand Our Diagnostic Toolkit Open
Background: Driving behavior as a digital marker and recent developments in blood-based biomarkers show promise as a widespread solution for the early identification of Alzheimer’s disease (AD). Objective: This study used artificial intell…
View article: Differential Impacts of Road Diets on Driving Behavior Among Older Adults with and Without Preclinical Alzheimer's Pathology
Differential Impacts of Road Diets on Driving Behavior Among Older Adults with and Without Preclinical Alzheimer's Pathology Open
View article: Cognitive and brain reserve predict decline in adverse driving behaviors among cognitively normal older adults
Cognitive and brain reserve predict decline in adverse driving behaviors among cognitively normal older adults Open
Daily driving is a multi-faceted, real-world, behavioral measure of cognitive functioning requiring multiple cognitive domains working synergistically to complete this instrumental activity of daily living. As the global population of olde…
View article: Associations Between Plasma, Imaging, Cerebrospinal Fluid Biomarkers and Naturalistic Driving Behaviors, Cognitive Tests Among Cognitively Normal Persons
Associations Between Plasma, Imaging, Cerebrospinal Fluid Biomarkers and Naturalistic Driving Behaviors, Cognitive Tests Among Cognitively Normal Persons Open
Background Previous work indicates that imaging and cerebrospinal fluid (CSF) amyloid and tau biomarkers are associated with driving behaviors, and that driving behaviors can be used to identify preclinical Alzheimer’s disease (AD). Along …
View article: Adverse driving behaviors increase over time as a function of preclinical Alzheimer's disease biomarkers
Adverse driving behaviors increase over time as a function of preclinical Alzheimer's disease biomarkers Open
Introduction We investigated the relationship between preclinical Alzheimer's disease (AD) biomarkers and adverse driving behaviors in a longitudinal analysis of naturalistic driving data. Methods Naturalistic driving data collected using …
View article: Neuropsychological Correlates of Changes in Driving Behavior Among Clinically Healthy Older Adults
Neuropsychological Correlates of Changes in Driving Behavior Among Clinically Healthy Older Adults Open
Objectives To determine the extent to which cognitive domain scores moderate change in driving behavior in cognitively healthy older adults using naturalistic (Global Positioning System-based) driving outcomes and to compare against self-r…
View article: Strategic adaptation to dual-task in verbal working memory: Potential routes for theory integration.
Strategic adaptation to dual-task in verbal working memory: Potential routes for theory integration. Open
How working memory supports dual-task performance is the focus of a long-standing debate. Most previous research on this topic has focused on participant performance data. In three experiments, we investigated whether changes in participan…
View article: Driving, Social Distancing, Protective, and Coping Behaviors of Older Adults Before and During COVID-19
Driving, Social Distancing, Protective, and Coping Behaviors of Older Adults Before and During COVID-19 Open
A thorough understanding of individual characteristics of older adults during the COVID-19 pandemic is critical for managing the ongoing pandemic course and planning for the future pandemics. Here, we explore the impact of the COVID-19 pan…
View article: Naturalistic driving measures of route selection associate with resting state networks in older adults
Naturalistic driving measures of route selection associate with resting state networks in older adults Open
View article: Adverse driving behaviors are associated with sleep apnea severity and age in cognitively normal older adults at risk for Alzheimer’s disease
Adverse driving behaviors are associated with sleep apnea severity and age in cognitively normal older adults at risk for Alzheimer’s disease Open
Alzheimer’s disease (AD) pathology accumulates for decades before the onset of cognitive decline. Cognitively normal individuals with biomarker evidence of AD brain pathology (i.e. biomarker + or preclinical AD) can be differentiated from …
View article: Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease
Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease Open
Alzheimer’s disease (AD) studies in cognitively normal (CN) older adults age≥65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern mod…
View article: The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity
The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity Open
Introduction We examined baseline differences in depression and antidepressant use among cognitively normal older adults in five ethnoracial groups and assessed whether depression predicted a faster progression to incident cognitive impair…
View article: Naturalistic Driving Measures of Route Selection Associate With Resting State Networks in Older Adults
Naturalistic Driving Measures of Route Selection Associate With Resting State Networks in Older Adults Open
Within a cohort of cognitively normal older individuals, we compared performance on naturalistic driving with resting state functional connectivity using machine learning. Functional networks associated with the ability to interpret and re…
View article: Exploring the influence of temporal factors on age differences in working memory dual task costs.
Exploring the influence of temporal factors on age differences in working memory dual task costs. Open
Working memory is defined by many as the system that allows us to simultaneously store information over brief time periods while engaging in other information processing activities. In a previous study (Rhodes, Jaroslawska et al. (2019) Jo…
View article: On‐site genetic analysis for species identification using lab‐on‐a‐chip
On‐site genetic analysis for species identification using lab‐on‐a‐chip Open
This paper presents a microfluidic device capable of performing genetic analysis on dung samples to identify White Rhinoceros ( Ceratotherium simum ). The development of a microfluidic device, which can be used in the field, offers a porta…