Jason M. Wood
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View article: CRISPR/Cas9-mediated deletion of MADD induces cell cycle arrest and apoptosis in anaplastic thyroid cancer cells
CRISPR/Cas9-mediated deletion of MADD induces cell cycle arrest and apoptosis in anaplastic thyroid cancer cells Open
View article: Assessing microbial diversity in Yellowstone National Park hot springs using a field deployable automated nucleic acid extraction system
Assessing microbial diversity in Yellowstone National Park hot springs using a field deployable automated nucleic acid extraction system Open
Microbial diversity estimation involves extracting nucleic acids from intricate sample matrices. Preparing nucleic acid samples is time-consuming, necessitating effective cell lysis and obtaining pure, inhibitor-free nucleic acid purificat…
View article: Prospective Approach to Deciphering the Impact of Intercellular Mitochondrial Transfer from Human Neural Stem Cells and Brain Tumor-Initiating Cells to Neighboring Astrocytes
Prospective Approach to Deciphering the Impact of Intercellular Mitochondrial Transfer from Human Neural Stem Cells and Brain Tumor-Initiating Cells to Neighboring Astrocytes Open
The communication between neural stem cells (NSCs) and surrounding astrocytes is essential for the homeostasis of the NSC niche. Intercellular mitochondrial transfer, a unique communication system that utilizes the formation of tunneling n…
View article: Geographic and Ecological Diversity of Green Sulfur Bacteria in Hot Spring Mat Communities
Geographic and Ecological Diversity of Green Sulfur Bacteria in Hot Spring Mat Communities Open
Three strains of thermophilic green sulfur bacteria (GSB) are known; all are from microbial mats in hot springs in Rotorua, New Zealand (NZ) and belong to the species Chlorobaculum tepidum. Here, we describe diverse populations of GSB inha…
View article: Characterization of metagenome-assembled genomes from the International Space Station
Characterization of metagenome-assembled genomes from the International Space Station Open
View article: Field deployable automated nucleic acid extraction system enables rapid on-site measurement of microbial diversity of Yellowstone National Park hot springs
Field deployable automated nucleic acid extraction system enables rapid on-site measurement of microbial diversity of Yellowstone National Park hot springs Open
Background: Microbial diversity estimation relies heavily on the extraction of nucleic acids from complex sample matrixes, regardless of the location of the laboratory used to recover the DNA, including those on Earth or in space. Nucleic …
View article: Metagenomic Methods for Addressing NASA's Planetary Protection Policy Requirements on Future Missions: A Workshop Report
Metagenomic Methods for Addressing NASA's Planetary Protection Policy Requirements on Future Missions: A Workshop Report Open
Molecular biology methods and technologies have advanced substantially over the past decade. These new molecular methods should be incorporated among the standard tools of planetary protection (PP) and could be validated for incorporation …
View article: Multi-faceted metagenomic analysis of spacecraft associated surfaces reveal planetary protection relevant microbial composition
Multi-faceted metagenomic analysis of spacecraft associated surfaces reveal planetary protection relevant microbial composition Open
The National Aeronautics and Space Administration (NASA) has been monitoring the microbial burden of spacecraft since the 1970’s Viking missions. Originally culture-based and then focused 16S sequencing techniques were used, but we have no…
View article: Multi-faceted metagenomic analysis of spacecraft associated surfaces reveal planetary protection relevant microbial composition
Multi-faceted metagenomic analysis of spacecraft associated surfaces reveal planetary protection relevant microbial composition Open
Supplemental tables and figures for manuscript titled: "Multi-faceted metagenomic analysis of spacecraft associated surfaces reveal planetary protection relevant microbial composition" Abstract NASA has been monitoring the…
View article: Multi-faceted metagenomic analysis of spacecraft associated surfaces reveal planetary protection relevant microbial composition
Multi-faceted metagenomic analysis of spacecraft associated surfaces reveal planetary protection relevant microbial composition Open
Supplemental tables and figures for manuscript titled: "Multi-faceted metagenomic analysis of spacecraft associated surfaces reveal planetary protection relevant microbial composition" Abstract NASA has been monitoring the…
View article: Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome
Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome Open
Background Antimicrobial resistance (AMR) has a detrimental impact on human health on Earth and it is equally concerning in other environments such as space habitat due to microgravity, radiation and confinement, especially for long-distan…
View article: Characterization of Metagenome Assembled Genomes from the International Space Station
Characterization of Metagenome Assembled Genomes from the International Space Station Open
Background Several investigations on the microbial diversity and functional properties of the International Space Station (ISS) environment were carried out to understand the influence of spaceflight conditions on the microbial population.…
View article: The Isolation and Characterization of Rare Mycobiome Associated With Spacecraft Assembly Cleanrooms
The Isolation and Characterization of Rare Mycobiome Associated With Spacecraft Assembly Cleanrooms Open
Ensuring biological cleanliness while assembling and launching spacecraft is critical for robotic exploration of the solar system. To date, when preventing forward contamination of other celestial bodies, NASA Planetary Protection policies…
View article: Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome
Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome Open
Background Antimicrobial Resistance (AMR) has a detrimental impact on human health on Earth and it is equally concerning in other environments such as space due to microgravity, radiation and confinement, especially for long-distance space…
View article: Genomic Characterization of Potential Plant Growth-Promoting Features of <i>Sphingomonas</i> Strains Isolated from the International Space Station
Genomic Characterization of Potential Plant Growth-Promoting Features of <i>Sphingomonas</i> Strains Isolated from the International Space Station Open
Sphingomonas is ubiquitous in nature, including the anthropogenically contaminated extreme environments. Members of the Sphingomonas genus have been identified as potential candidates for space biomining beyond earth.
View article: Additional file 5 of Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome
Additional file 5 of Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome Open
Additional file 5: File S1. Raw results of the DeepARG analyses (zip compressed).
View article: Additional file 4 of Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome
Additional file 4 of Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome Open
Additional file 4: Table S2. Phenotypic antibiotic resistance testing results for E. bugandensis and B cereus.
View article: Additional file 3 of Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome
Additional file 3 of Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome Open
Additional file 3: Table S1. Rank of MT-1 isolates, ordered by number of ARGs predicted, shown in Fig. 4a. Species information obtained from Microbial Nucleotide BLAST.
View article: Performance of Multiple Metagenomics Pipelines in Understanding Microbial Diversity of a Low-Biomass Spacecraft Assembly Facility
Performance of Multiple Metagenomics Pipelines in Understanding Microbial Diversity of a Low-Biomass Spacecraft Assembly Facility Open
NASA planetary protection (PP) requires an assessment of the biological contamination of the potential microbial burden on spacecraft destined to explore planetary bodies that may harbor signs of life, like Mars and Europa. To help meet th…
View article: Draft Genome Sequences of Fungi Isolated from the International Space Station during the Microbial Tracking-2 Experiment
Draft Genome Sequences of Fungi Isolated from the International Space Station during the Microbial Tracking-2 Experiment Open
As part of the Microbial Tracking-2 study, 94 fungal strains were isolated from surfaces on the International Space Station, and whole-genome sequences were assembled. Characterization of these draft genomes will allow evaluation of microg…
View article: Draft Genome Sequences of Heat Shock-Tolerant Microbes Isolated from a Spacecraft Assembly Facility
Draft Genome Sequences of Heat Shock-Tolerant Microbes Isolated from a Spacecraft Assembly Facility Open
Heat shock-tolerant microorganisms belonging to the orders Bacillales and Micrococcales were isolated from the Spacecraft Assembly Facility at the Jet Propulsion Laboratory, and 63 draft genome sequences were assembled and identified. Furt…
View article: Draft Genome Sequences of Various Bacterial Phyla Isolated from the International Space Station
Draft Genome Sequences of Various Bacterial Phyla Isolated from the International Space Station Open
Whole-genome sequences were generated from 96 bacterial strains of 14 species that were isolated from International Space Station surfaces during the Microbial Tracking 2 study. Continued characterization of this closed habitat's microbiom…
View article: A comprehensive metagenomics framework to characterize organisms relevant for planetary protection
A comprehensive metagenomics framework to characterize organisms relevant for planetary protection Open
View article: Draft Genome Sequences of <i>Aspergillus</i> and <i>Penicillium</i> Species Isolated from the International Space Station and Crew Resupply Vehicle Capsule
Draft Genome Sequences of <i>Aspergillus</i> and <i>Penicillium</i> Species Isolated from the International Space Station and Crew Resupply Vehicle Capsule Open
The draft whole-genome sequences (WGS) of 30 fungal strains isolated from the International Space Station and belonging to the Penicillium and Aspergillus genera were assembled. The WGS will allow for detailed genomic characterization to d…
View article: Assessing the Risk of Transfer of Microorganisms at the International Space Station Due to Cargo Delivery by Commercial Resupply Vehicles
Assessing the Risk of Transfer of Microorganisms at the International Space Station Due to Cargo Delivery by Commercial Resupply Vehicles Open
The metagenome sequence comparison of the CRV microbiome with the ISS microbiome revealed significant differences showing that CRV microbiomes were a negligible part of the ISS environmental microbiome. These findings suggest that the main…
View article: Draft Genome Sequences of <i>Bacillaceae</i> Strains Isolated from the International Space Station
Draft Genome Sequences of <i>Bacillaceae</i> Strains Isolated from the International Space Station Open
The draft genome sequences of 29 bacterial isolates belonging to the family Bacillaceae were collected from the International Space Station, assembled, and identified. Further analysis of these sequences will enable us to understand their …
View article: Draft Genome Sequences of <i>Klebsiella</i> Species Isolated from the International Space Station
Draft Genome Sequences of <i>Klebsiella</i> Species Isolated from the International Space Station Open
Isolated across four locations aboard the International Space Station (ISS), 10 bacterial strains were compared using whole-genome sequencing analysis and were phylogenetically identified as Klebsiella . The whole-genome sequences will aid…
View article: End-to-End Protocol for the Detection of SARS-CoV-2 from Built Environments
End-to-End Protocol for the Detection of SARS-CoV-2 from Built Environments Open
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (the virus responsible for coronavirus disease 2019 [COVID-19]) pandemic has led to a global slowdown with far-reaching financial and social impacts. The SARS-CoV-2 r…
View article: Draft Genome Sequences of <i>Lactobacillales</i> Isolated from the International Space Station
Draft Genome Sequences of <i>Lactobacillales</i> Isolated from the International Space Station Open
Nineteen strains from the order Lactobacillales were isolated from the International Space Station and commercial resupply vehicle, and whole-genome sequences (WGS) were generated. WGS would permit the characterization of these potentially…
View article: Draft Genome Sequences of <i>Enterobacteriales</i> Strains Isolated from the International Space Station
Draft Genome Sequences of <i>Enterobacteriales</i> Strains Isolated from the International Space Station Open
The whole-genome sequences of 26 strains isolated from the International Space Station were generated, and the strains were identified as being members of the order Enterobacteriales. Characterization of these whole-genome sequences might …