Juan Pang
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View article: <b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b>
<b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b> Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: <b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b>
<b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b> Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice
Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: Estimating Effective Fracture Pore Volume and the Efficiency of Imbibition-Driven Oil Recovery Using Two-Phase Flowback Data
Estimating Effective Fracture Pore Volume and the Efficiency of Imbibition-Driven Oil Recovery Using Two-Phase Flowback Data Open
By providing sufficient time for oil to migrate from the matrix into the fractures through imbibition, the extended shut-in period contributes to immediate oil production in shale oil reservoirs. Previous studies have demonstrated that flo…
View article: Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice
Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice Open
We conclude that hepatic FGF21 is required for curcumin or resveratrol in exerting their major metabolic beneficial effect. The recognition that FGF21 as the common target of dietary intervention, demonstrated in current as well as previou…
View article: <scp>miR</scp>‐92a aggravates metabolic syndrome via <scp>KLF2</scp>/<scp>miR</scp>‐483 axis
<span>miR</span>‐92a aggravates metabolic syndrome via <span>KLF2</span>/<span>miR</span>‐483 axis Open
Objective To exam the role of miR‐92a/KLF2/miR‐483 in the pathogenesis of metabolic syndrome. Methods In this study, the serum of healthy controls and patients with metabolic syndrome were collected to detect the circulating level of miR‐9…
View article: Biomimetic Self-Adhesive Hydrogel Sensor Combining Lignin-Alginate Interpenetrating Network and Core-Shell Conductivity for Anti Freezing and Anti Dehydration Health Monitoring
Biomimetic Self-Adhesive Hydrogel Sensor Combining Lignin-Alginate Interpenetrating Network and Core-Shell Conductivity for Anti Freezing and Anti Dehydration Health Monitoring Open
View article: Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice
Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice Open
Conclusion and significance: We conclude that hepatic FGF21 is required for curcumin or resveratrol in exerting their major metabolic beneficial effect. The recognition that FGF21 as the common target of dietary interventions brings us a n…
View article: Resveratrol Improves Hyperuricemia and Ameliorates Renal Injury by Modulating the Gut Microbiota
Resveratrol Improves Hyperuricemia and Ameliorates Renal Injury by Modulating the Gut Microbiota Open
Resveratrol (RES) has been reported to prevent hyperuricemia (HUA); however, its effect on intestinal uric acid metabolism remains unclear. This study evaluated the impact of RES on intestinal uric acid metabolism in mice with HUA induced …
View article: Anthocyanin attenuates disturbance of intestinal barrier in high fat-high cholesterol diet-challenged mice through regulating the response of T helper 17 cells
Anthocyanin attenuates disturbance of intestinal barrier in high fat-high cholesterol diet-challenged mice through regulating the response of T helper 17 cells Open
Anthocyanin, as a typical food bioactive molecule, is capable of reversing inflammatory, oxidative and allergic condition thus contributes to intestinal health. We were wondering whether anthocyanin has influence on the infiltration of inf…
View article: Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis
Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis Open
View article: Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1
Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1 Open
Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I)…
View article: Commentary: Can FXR serve as a potential target for COVID-19 prevention?
Commentary: Can FXR serve as a potential target for COVID-19 prevention? Open
View article: A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia
A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia Open
Resveratrol is a polyphenol with a well-established beneficial effect on dyslipidemia and hyperuricemia in preclinical experiments. Nonetheless, its efficacy and dose–response relationship in clinical trials remains unclear. This study exa…
View article: untargeted metabolomics analysis of fecal extract after resveratrol treatment
untargeted metabolomics analysis of fecal extract after resveratrol treatment Open
In a previous study, we found that resveratrol could inhibit chylomicron secretion and jejunal SR-B1 expression, and the effects were mediated by gut microbiota and some heat-stable metabolites in the feces of mice which received resveratr…
View article: Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1
Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1 Open
Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I)…
View article: Dietary resveratrol intervention improves lipid homeostasis via attenuating HFD-induced fecal chenodeoxycholic acid and jejunum SR-B1 elevation
Dietary resveratrol intervention improves lipid homeostasis via attenuating HFD-induced fecal chenodeoxycholic acid and jejunum SR-B1 elevation Open
Two common features of dietary polyphenols have hampered our mechanistic understanding of their metabolic beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol interventi…
View article: Global burden of nonalcoholic steatohepatitis-related liver cancer, 1990–2019: a systematic analysis for the GBD 2019
Global burden of nonalcoholic steatohepatitis-related liver cancer, 1990–2019: a systematic analysis for the GBD 2019 Open
View article: The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs—Therapeutic potential exploration in lung injury
The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs—Therapeutic potential exploration in lung injury Open
Since 2005, GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) have been developed as therapeutic agents for type 2 diabetes (T2D). GLP-1R is not only expressed in pancreatic islets but also other organs, especially the lung. However, controversy…
View article: Liraglutide stimulates the β-catenin signaling cascade in mouse epididymal fat tissue
Liraglutide stimulates the β-catenin signaling cascade in mouse epididymal fat tissue Open
Although canonical Wnt signaling pathway activation was shown to negatively regulate adipogenesis, recent investigations suggest that Wnt pathway effectors TCF7L2 and β-catenin (β-cat) in adipose tissues are also involved in energy homeost…
View article: The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs -- Therapeutic potential exploration in lung injury
The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs -- Therapeutic potential exploration in lung injury Open
Since 2005, GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) have been developed as therapeutic agents for Type 2 diabetes. GLP-1R is not only expressed in pancreatic islets but also in other organs, especially the lung. Extra-pancreatic expres…
View article: Pancreatic β-Cell Dysfunction Is Associated with Nonalcoholic Fatty Liver Disease
Pancreatic β-Cell Dysfunction Is Associated with Nonalcoholic Fatty Liver Disease Open
Background: Nonalcoholic fatty liver disease (NAFLD) is associated with decreased insulin sensitivity. However, the association between NAFLD and pancreatic β-cell function is still ambiguous. Here, we assessed whether pancreatic β-cell fu…
View article: Friend or foe? ACE2 inhibitors and GLP-1R agonists in COVID-19 treatment
Friend or foe? ACE2 inhibitors and GLP-1R agonists in COVID-19 treatment Open
View article: Hydrogen phosphate-mediated acellular biomineralisation within a dual crosslinked hyaluronic acid hydrogel
Hydrogen phosphate-mediated acellular biomineralisation within a dual crosslinked hyaluronic acid hydrogel Open
View article: Synthesis and Investigation of Macromolecular Photoswitches
Synthesis and Investigation of Macromolecular Photoswitches Open
The photoisomerization of azobenzene (AZO) makes it a potential type of photoswitch for the field of chemical engineering. However, the lack of stability and photobleaching characteristics of reversible photoisomerization have restricted f…
View article: Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose–response manner in subjects with dyslipidemia
Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose–response manner in subjects with dyslipidemia Open
Supplementation of anthocyanins for 12 weeks positively improved the anti-oxidative and anti-inflammatory capacity in a dose-response manner in individuals with dyslipidemia.
View article: Theoretical insights into a colorimetric azo-based probe to detect copper ions
Theoretical insights into a colorimetric azo-based probe to detect copper ions Open
DFT calculations indicated that the rotation of the N,N-di(carboxymethyl)amino group around the N–CAr bond by approximately 90°, resulted in a larger HOMO–LUMO energy gap, and led to the observed colour change.
View article: Design, synthesis, and investigation of a visible light-driven photo-switching macromolecule
Design, synthesis, and investigation of a visible light-driven photo-switching macromolecule Open
The application of azobenzene (AZO) as a kind of photo-switch is restricted by its excitation source, i.e., UV light.
View article: Serum SHBG Is Associated With the Development and Regression of Nonalcoholic Fatty Liver Disease: A Prospective Study
Serum SHBG Is Associated With the Development and Regression of Nonalcoholic Fatty Liver Disease: A Prospective Study Open
Context SHBG, a homodimeric glycoprotein produced by hepatocytes has been shown to be associated with metabolic disorders. Whether circulating SHBG levels are predictive of later risk of nonalcoholic fatty liver disease (NAFLD) remains unk…
View article: Fabrication, Investigation, and Application of Light-Responsive Self-Assembled Nanoparticles
Fabrication, Investigation, and Application of Light-Responsive Self-Assembled Nanoparticles Open
Light-responsive materials have attracted increasing interest in recent years on account of their adjustable on-off properties upon specific light. In consideration of reversible isomerization transition for azobenzene (AZO), it was design…