Jason Nideffer
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View article: CXCR6⁺ CD127⁻ Tr1 Cells Balance Immunity and Persistence in Plasmodium falciparum Infection
CXCR6⁺ CD127⁻ Tr1 Cells Balance Immunity and Persistence in Plasmodium falciparum Infection Open
Plasmodium falciparum ( Pf ) induces the clonal expansion of antigen-specific type 1 regulatory T (Tr1) cells with a capacity for long-term memory. Tr1 cells comprise nearly 90% of the Pf blood stage antigen-specific CD4+ T cell pool in ch…
View article: Clinical immunity to malaria involves epigenetic reprogramming of innate immune cells
Clinical immunity to malaria involves epigenetic reprogramming of innate immune cells Open
The regulation of inflammation is a critical aspect of disease tolerance and naturally acquired clinical immunity to malaria. Here, we demonstrate using RNA sequencing and epigenetic landscape profiling by cytometry by time-of-flight, that…
View article: CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites
CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites Open
View article: Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells
Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells Open
Human adaptive immunity is orchestrated by effector and regulatory T (Treg) cells. Natural Tregs arise in the thymus where they are shaped to recognize self-antigens, while type 1 Tregs or Tr1 cells are induced from conventional peripheral…
View article: Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with <i>FOXP3</i> mutations
Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with <i>FOXP3</i> mutations Open
Studies of the monogenic autoimmune disease immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX) have elucidated the essential function of the transcription factor FOXP3 and thymic-derived regulatory T cells (T regs …
View article: Disease Tolerance Acquired Through Repeated<i>Plasmodium</i>Infection Involves Epigenetic Reprogramming of Innate Immune Cells
Disease Tolerance Acquired Through Repeated<i>Plasmodium</i>Infection Involves Epigenetic Reprogramming of Innate Immune Cells Open
Summary The regulation of inflammation is a critical aspect of disease tolerance and naturally acquired immunity to malaria. Here, we demonstrate using RNA sequencing and epigenetic landscape profiling by cytometry by Time-Of-Flight (EpiTO…
View article: CD4<sup>+</sup>T cells display a spectrum of recall dynamics during re-infection with malaria parasites
CD4<sup>+</sup>T cells display a spectrum of recall dynamics during re-infection with malaria parasites Open
Children in malaria-endemic regions can experience multiple Plasmodium infections over a short period of time, with in vitro CD4 + T cell recall responses becoming more regulatory with increasing age and exposure. This suggests that repeat…
View article: Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria Open
Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan chil…
View article: Type I regulatory T cells in malaria: of mice and men
Type I regulatory T cells in malaria: of mice and men Open
Type I regulatory T (Tr1) cells are a population of regulatory CD4+ T cells implicated in the suppression of pathological immune responses across multiple diseases, but a unifying transcriptional signature of Tr1 identity across disease co…
View article: Disease Tolerance of Malaria Involves Epigenetic Reprogramming of Innate Immune Cells
Disease Tolerance of Malaria Involves Epigenetic Reprogramming of Innate Immune Cells Open
View article: Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria Open
Natural Killer (NK) cells likely play an important role in immunity to malaria, but whether repeated malaria modifies the NK cell response remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan c…