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View article: Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation, but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 253 isolate…
View article: Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 253 isolates…
View article: <i>Candida auris</i> surveillance in the Military Health System: a multidrug-resistant threat
<i>Candida auris</i> surveillance in the Military Health System: a multidrug-resistant threat Open
Objective: To evaluate the potential sources and current screening strategies for the multidrug-resistant fungal pathogen Candida auris in the US Military Health System (MHS). Methods: Utilizing the Multidrug-Resistant Organism Repository …
View article: Reviewer #2 (Public Review): Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Reviewer #2 (Public Review): Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 254 isolates…
View article: Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 254 isolates…
View article: Reviewer #1 (Public Review): Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Reviewer #1 (Public Review): Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 254 isolates…
View article: Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics
Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation, but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 253 isolate…
View article: Detecting, mapping, and suppressing the spread of a decade-long <i>Pseudomonas aeruginosa</i> nosocomial outbreak with genomics
Detecting, mapping, and suppressing the spread of a decade-long <i>Pseudomonas aeruginosa</i> nosocomial outbreak with genomics Open
Whole-genome sequencing is revolutionizing bacterial outbreak investigation but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 253 isolates…
View article: Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities
Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities Open
A. baumannii is recognized as one of the most important nosocomial pathogens, and carbapenem-resistant strains pose a particularly difficult treatment challenge. Outbreaks linked to this pathogen are reported worldwide, particularly during…
View article: The Emergence and Persistence of<i>Candida auris</i>in Western New York With No Epidemiologic Links: A Failure of Stewardship?
The Emergence and Persistence of<i>Candida auris</i>in Western New York With No Epidemiologic Links: A Failure of Stewardship? Open
Reports of Candida auris infection in patients without epidemiologic links to prior outbreaks are scarce. We describe the genomic epidemiology of such a case in Western New York. Before emergence, the patient received >60 days of excess…
View article: Mechanisms of IS <i>26</i> -Mediated Amplification of the <i>aphA1</i> Gene Leading to Tobramycin Resistance in an Acinetobacter baumannii Isolate
Mechanisms of IS <i>26</i> -Mediated Amplification of the <i>aphA1</i> Gene Leading to Tobramycin Resistance in an Acinetobacter baumannii Isolate Open
Heteroresistance, a significant issue that is known to impact antibiotic treatment outcomes, is caused by the presence of spontaneously arising cells with elevated levels of resistance to therapeutically important antibiotics in a populati…
View article: Complete genome of the extensively antibiotic-resistant GC1 <i>Acinetobacter baumannii</i> isolate MRSN 56 reveals a novel route to fluoroquinolone resistance
Complete genome of the extensively antibiotic-resistant GC1 <i>Acinetobacter baumannii</i> isolate MRSN 56 reveals a novel route to fluoroquinolone resistance Open
Objectives To examine the causes of antibiotic resistance in the extensively resistant global clone 1 (GC1) Acinetobacter baumannii isolate MRSN 56 recovered at a US military treatment facility. Methods MRSN 56 was sequenced using MinION (…
View article: Anatomy of an extensively drug-resistant <i>Klebsiella pneumoniae</i> outbreak in Tuscany, Italy
Anatomy of an extensively drug-resistant <i>Klebsiella pneumoniae</i> outbreak in Tuscany, Italy Open
Significance Carbapenem-resistant Klebsiella pneumoniae belongs to the “critical-priority” tier of bacterial pathogens as identified by the World Health Organization. Emerging “high-risk” lineages are responsible for difficult-to-treat, ho…
View article: A panel of diverse <i>Pseudomonas aeruginosa</i> clinical isolates for research and development
A panel of diverse <i>Pseudomonas aeruginosa</i> clinical isolates for research and development Open
Objectives Pseudomonas aeruginosa is a leading cause of community- and hospital-acquired infections. Successful treatment is hampered by its remarkable ability to rapidly develop resistance to antimicrobial agents, primarily through mutati…
View article: Clinical Characteristics and Resistance Patterns of Pseudomonas aeruginosa Isolated From Combat Casualties
Clinical Characteristics and Resistance Patterns of Pseudomonas aeruginosa Isolated From Combat Casualties Open
Introduction Multidrug-resistant (MDR) Gram-negative infections complicate care of combat casualties. We describe the clinical characteristics, resistance patterns, and outcomes of Pseudomonas aeruginosa infections in combat casualties. Me…
View article: Anatomy of an Extensively Drug Resistant <i>Klebsiella pneumoniae</i> Outbreak in Tuscany, Italy
Anatomy of an Extensively Drug Resistant <i>Klebsiella pneumoniae</i> Outbreak in Tuscany, Italy Open
A protracted outbreak of New Delhi metallo-beta-lactamase (NDM)-producing carbapenem-resistant Klebsiella pneumoniae , started in Tuscany, Italy, in November 2018 and continued in 2020 and through 2021. To understand the regional emergence…
View article: A Panel of Diverse<i>Pseudomonas aeruginosa</i>Clinical Isolates for Research and Development
A Panel of Diverse<i>Pseudomonas aeruginosa</i>Clinical Isolates for Research and Development Open
Pseudomonas aeruginosa is a leading cause of community-acquired and hospital-acquired infections. Successful treatment is hampered by its remarkable ability to rapidly develop resistance to antimicrobial agents, mostly through mutation. In…
View article: Travel-associated multidrug-resistant organism acquisition and risk factors among US military personnel
Travel-associated multidrug-resistant organism acquisition and risk factors among US military personnel Open
Background International travel is a risk factor for incident colonization with extended spectrum beta-lactamase (ESBL)-producing organisms. These and other multidrug-resistant (MDR) bacteria are major pathogens in combat casualties. We ev…
View article: Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya Open
Carbapenem-resistant gram-negative bacteria are an increasingly significant clinical threat globally. This risk may be underestimated in Kenya as only four carbapenemase genes in three bacterial species have been described. The study aimed…
View article: A Diverse Panel of Clinical Acinetobacter baumannii for Research and Development
A Diverse Panel of Clinical Acinetobacter baumannii for Research and Development Open
Over the past two decades, Acinetobacter baumannii has emerged as a leading cause of nosocomial infections worldwide. Of particular concern are panresistant strains, leading the World Health Organization (WHO) to designate carbapenem-resis…
View article: Bacteraemia due to Microbacterium paraoxydans in a patient with chronic kidney disease, refractory hypertension and sarcoidosis
Bacteraemia due to Microbacterium paraoxydans in a patient with chronic kidney disease, refractory hypertension and sarcoidosis Open
Introduction. Microbacterium spp. are yellow-pigmented Gram-positive coryneform rods found in various environmental sources, such as soil and water samples. They rarely cause human infection, mostly infecting immunocompromised patients and…
View article: ICE volume 39 issue 1 Cover and Front matter
ICE volume 39 issue 1 Cover and Front matter Open
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View article: Complete Genome Sequence of Staphylococcus epidermidis 1457
Complete Genome Sequence of Staphylococcus epidermidis 1457 Open
Staphylococcus epidermidis 1457 is a frequently utilized strain that is amenable to genetic manipulation and has been widely used for biofilm-related research. We report here the whole-genome sequence of this strain, which encodes 2,277 pr…
View article: Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling
Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling Open
The availability of genetically tractable organisms with simple genomes is critical for the rapid, systems-level understanding of basic biological processes. Mycoplasma bacteria, with the smallest known genomes among free-living cellular o…