Jason S. Leith
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View article: Convex lens-induced nanoscale templating
Convex lens-induced nanoscale templating Open
Significance Convex lens-induced nanoscale templating (CLINT) represents a conceptual breakthrough in nanofluidic technology for single-molecule manipulation. CLINT solves a key challenge faced by the nanofluidics field by bridging the mul…
View article: Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC)
Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC) Open
Resolving single fluorescent molecules in the presence of high fluorophore concentrations remains a challenge in single-molecule biophysics that limits our understanding of weak molecular interactions. Total internal reflection fluorescenc…
View article: The Facilitation of Protein-DNA Search and Recognition by Multiple Modes of Binding
The Facilitation of Protein-DNA Search and Recognition by Multiple Modes of Binding Open
The studies discussed in this thesis unify experimental and theoretical techniques, both established and novel, in investigating the problem of how a protein that binds specific sites on DNA translocates to, recognizes, and stably binds to…
View article: Sequence-dependent sliding kinetics of p53
Sequence-dependent sliding kinetics of p53 Open
Proper timing of gene expression requires that transcription factors (TFs) efficiently locate and bind their target sites within a genome. Theoretical studies have long proposed that one-dimensional sliding along DNA while simultaneously r…
View article: Sequence-dependent sliding kinetics of p53
Sequence-dependent sliding kinetics of p53 Open
Proper timing of gene expression requires that transcription factors (TFs) efficiently locate and bind their target sites within a genome. Theoretical studies have long proposed that one-dimensional sliding along DNA while simultaneously r…
View article: Sequence-Dependent Kinetics of One-Dimensional Diffusion of p53 on DNA
Sequence-Dependent Kinetics of One-Dimensional Diffusion of p53 on DNA Open
View article: Single-molecule Studies Of p53 Sliding Along DNA
Single-molecule Studies Of p53 Sliding Along DNA Open
View article: Tumor Suppressor p53 Slides on DNA with Low Friction and High Stability
Tumor Suppressor p53 Slides on DNA with Low Friction and High Stability Open