Jean‐Louis Vincent
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View article: Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score Open
Importance Acute dysfunction of vital organs is the hallmark of critical illness. The Sequential Organ Failure Assessment (SOFA) score, the most widely adopted approach to describe organ dysfunction, has not been updated in 30 years and th…
View article: Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score
Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score Open
Importance The Sequential Organ Failure Assessment (SOFA) score was published in 1996 to describe organ dysfunction in critically ill adult patients in a readily quantifiable and sequential manner. Considerable changes have occurred over t…
View article: Eliminating the AI digital divide by building local capacity
Eliminating the AI digital divide by building local capacity Open
Over the past few years, health delivery organizations (HDOs) have been adopting and integrating AI tools, including clinical tools for tasks like predicting risk of inpatient mortality and operational tools for clinical documentation, sch…
View article: The 15th Anniversary of Life—Sepsis Trials
The 15th Anniversary of Life—Sepsis Trials Open
Clinical trials of drugs specifically targeting the sepsis response have frequently produced negative or inconclusive results. This has largely been due to the broad heterogeneity of enrolled patient populations, particularly when inclusio…
View article: Expanding care coordination in an integrated health system through causal machine learning
Expanding care coordination in an integrated health system through causal machine learning Open
Hospital readmission is a key quality metric, yet post-discharge interventions often yield variable results. In the first large-scale randomized evaluation of causal machine learning in a health system, we assessed whether a novel model (t…
View article: A Restrictive Versus a Liberal Transfusion Strategy in Patients With Spontaneous Intracerebral Hemorrhage: A Secondary Analysis of TRAIN Randomized Clinical Trial
A Restrictive Versus a Liberal Transfusion Strategy in Patients With Spontaneous Intracerebral Hemorrhage: A Secondary Analysis of TRAIN Randomized Clinical Trial Open
BACKGROUND: Red blood cell transfusions are commonly administered to anemic patients with spontaneous intracerebral hemorrhage (ICH); however, the optimal hemoglobin threshold to initiate transfusion is uncertain in this population. Theref…
View article: Liberal versus restrictive transfusion strategies in subarachnoid hemorrhage: a secondary analysis of the TRAIN study
Liberal versus restrictive transfusion strategies in subarachnoid hemorrhage: a secondary analysis of the TRAIN study Open
ClinicalTrials.gov number-NCT02968654 registered on November 16th, 2016.
View article: Effectiveness of Sound‐Based Interventions for Improving Functional Outcomes in Children: A Systematic Review of the Evidence
Effectiveness of Sound‐Based Interventions for Improving Functional Outcomes in Children: A Systematic Review of the Evidence Open
Introduction: The aim of this review was to examine the evidence for sound‐based interventions in decreasing auditory hypersensitivity and improving behavioural and emotional regulation among children. Methods: A systematic review was cond…
View article: Use of extracorporeal blood purification therapies in sepsis: the current paradigm, available evidence, and future perspectives
Use of extracorporeal blood purification therapies in sepsis: the current paradigm, available evidence, and future perspectives Open
Given the heterogeneity of patients with sepsis, conducting traditional randomized clinical trials in this domain can be a daunting task. However, statistical techniques such as Bayesian methods, propensity score analysis, and emulated cli…
View article: Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method
Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method Open
Using a Delphi method, international experts reached consensus to generate expert clinical practice statements providing guidance to clinicians worldwide on the management of sepsis in resource-limited settings. These statements complement…
View article: Vasopressor Therapy
Vasopressor Therapy Open
Vasopressor therapy represents a key part of intensive care patient management, used to increase and maintain vascular tone and thus adequate tissue perfusion in patients with shock. Norepinephrine is the preferred first-line agent because…
View article: The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II
The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II Open
Dysregulation of the renin–angiotensin–aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and in…
View article: Decision Support Guided Fluid Challenges and Stroke Volume Response during High-Risk Surgery: A Post Hoc Analysis of a Randomized Controlled Trial
Decision Support Guided Fluid Challenges and Stroke Volume Response during High-Risk Surgery: A Post Hoc Analysis of a Randomized Controlled Trial Open
Purpose Intravenous fluid is administered during high-risk surgery to optimize stroke volume (SV). To assess ongoing need for fluids, the hemodynamic response to a fluid bolus is evaluated using a fluid challenge technique. The Acumen Assi…
View article: Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury Open
Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 …
View article: Exploration of different statistical approaches in the comparison of dopamine and norepinephrine in the treatment of shock: SOAP II
Exploration of different statistical approaches in the comparison of dopamine and norepinephrine in the treatment of shock: SOAP II Open
Background Exploring clinical trial data using alternative methods may enhance original study’s findings and provide new insights. The SOAP II trial has been published more than 10 years ago; but there is still some speculation that some p…
View article: Management of Adult Sepsis in Resource-Limited Settings: Global Expert Consensus Statements Using a Delphi Method
Management of Adult Sepsis in Resource-Limited Settings: Global Expert Consensus Statements Using a Delphi Method Open
Purpose To generate consensus and provide expert clinical practice statements for the management of adult sepsis in resource-limited settings. Methods An international multidisciplinary Steering Committee with expertise in sepsis managemen…
View article: Opioid Administration Practice Patterns in Patients With Acute Respiratory Failure Who Undergo Invasive Mechanical Ventilation
Opioid Administration Practice Patterns in Patients With Acute Respiratory Failure Who Undergo Invasive Mechanical Ventilation Open
IMPORTANCE: The opioid crisis is impacting people across the country and deserves attention to be able to curb the rise in opioid-related deaths. OBJECTIVES: To evaluate practice patterns in opioid infusion administration and dosing for pa…
View article: Circulating Nucleosomes as a Novel Biomarker for Sepsis: A Scoping Review
Circulating Nucleosomes as a Novel Biomarker for Sepsis: A Scoping Review Open
Circulating nucleosome levels are commonly elevated in physiological and pathological conditions. Their potential as biomarkers for diagnosing and prognosticating sepsis remains uncertain due, in part, to technical limitations in existing …