Jason W. Busse
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View article: Intraoperative parathyroid hormone monitoring criteria in secondary and tertiary hyperparathyroidism: A systematic review
Intraoperative parathyroid hormone monitoring criteria in secondary and tertiary hyperparathyroidism: A systematic review Open
View article: Corrigendum to ‘Letter to the Editor regarding, “Multisociety response to The BMJ publications on interventional spine procedures for chronic back and neck pain,” by Rittenberg’ [The Spine Journal 25 (2025) 1853-1854]
Corrigendum to ‘Letter to the Editor regarding, “Multisociety response to The BMJ publications on interventional spine procedures for chronic back and neck pain,” by Rittenberg’ [The Spine Journal 25 (2025) 1853-1854] Open
View article: Efficacy and safety of endovascular treatment for acute ischemic stroke due to medium and distal vessel occlusion: a protocol for a systematic review and meta-analysis
Efficacy and safety of endovascular treatment for acute ischemic stroke due to medium and distal vessel occlusion: a protocol for a systematic review and meta-analysis Open
Introduction Endovascular thrombectomy (EVT) improves outcomes in large-vessel occlusion (LVO) stroke and has recently shown benefit in dominant M2 occlusions. However, its role in medium vessel occlusions (MeVO) and distal vessel occlusio…
View article: Nonregistration, Discontinuation, and Nonpublication of Randomized Trials
Nonregistration, Discontinuation, and Nonpublication of Randomized Trials Open
Importance Previous work found that 25% to 30% of randomized clinical trials (RCTs) with protocols approved in 2012 or between 2000 and 2003 were discontinued prematurely, most commonly due to inadequate participant recruitment. To minimiz…
View article: Establishing a framework of measurement for use in Long COVID research and practice: protocol for a scoping review involving evidence review and consultation
Establishing a framework of measurement for use in Long COVID research and practice: protocol for a scoping review involving evidence review and consultation Open
Introduction Our aim is to develop a Framework of Measurement for people living with Long COVID and their caregivers for use in Long COVID research and clinical practice. Specifically, we will characterise evidence pertaining to outcome me…
View article: Perceptions of barriers and facilitators to opioid reduction after total joint arthroplasty among orthopedic surgeons practicing in Canada, Japan, and the Netherlands: A qualitative description study
Perceptions of barriers and facilitators to opioid reduction after total joint arthroplasty among orthopedic surgeons practicing in Canada, Japan, and the Netherlands: A qualitative description study Open
Opioid analgesics are commonly prescribed after total knee and hip arthroplasty to manage pain. Rates of opioid prescribing after arthroplasty differ by country, suggesting differences in policies or surgeons’ practices. We adopted a quali…
View article: Consolidation, Systematic Appraisal and Comparison of Guideline Recommendations Regarding Management of Chronic Pain: Protocol for a Digital Chronic Pain Recommendation Map
Consolidation, Systematic Appraisal and Comparison of Guideline Recommendations Regarding Management of Chronic Pain: Protocol for a Digital Chronic Pain Recommendation Map Open
Introduction Chronic pain affects 1 in 5 adults and children globally; however, management remains highly variable and low value care is common. Inconsistent recommendations among clinical practice guidelines for management of chronic pain…
View article: Opioid analgesics for chronic noncancer pain in patients prescribed opioid agonist therapy or with opioid use disorder: A systematic review
Opioid analgesics for chronic noncancer pain in patients prescribed opioid agonist therapy or with opioid use disorder: A systematic review Open
There is a paucity of evidence to inform practice and policy regarding opioid analgesic prescribing amongst people with OUD. Existing evidence suggests that such prescribing is associated with a higher risk of suicidality, while the use of…
View article: Intraoperative parathyroid hormone monitoring to guide surgery in renal hyperparathyroidism (PEREGRINE): a protocol for a randomised multiarm surgical pilot trial
Intraoperative parathyroid hormone monitoring to guide surgery in renal hyperparathyroidism (PEREGRINE): a protocol for a randomised multiarm surgical pilot trial Open
Background Secondary and tertiary renal hyperparathyroidism (RHPT) are common sequelae of chronic kidney disease and are associated with worse patient mortality and quality of life. Clinical guidelines remain lacking with regard to recomme…
View article: Prevalence of symptom exaggeration among North American independent medical evaluation examinees: A systematic review of observational studies
Prevalence of symptom exaggeration among North American independent medical evaluation examinees: A systematic review of observational studies Open
Background Independent medical evaluations (IMEs) are commonly acquired to provide an assessment of impairment; however, these assessments show poor inter-rater reliability. One potential contributor is symptom exaggeration by patients, wh…
View article: Public availability of randomized clinical trial protocols: a repeated meta-research study
Public availability of randomized clinical trial protocols: a repeated meta-research study Open
The availability of protocols increased in RCTs approved in 2016 compared to RCTs from 2012. This was mainly driven by industry sponsored trials. Efforts to further improve protocol availability should be continued, especially in nonindust…
View article: Intercostobrachial nerve preservation during breast cancer surgery to prevent chronic postsurgical pain: A systematic review and meta-analysis of randomized controlled trials
Intercostobrachial nerve preservation during breast cancer surgery to prevent chronic postsurgical pain: A systematic review and meta-analysis of randomized controlled trials Open
View article: Reduced perioperative sensory deprivation could lower postoperative delirium incidence: A prospective observational cohort study in older patients with hip fracture
Reduced perioperative sensory deprivation could lower postoperative delirium incidence: A prospective observational cohort study in older patients with hip fracture Open
Background Postoperative delirium (POD) is a common complication in older patients. Multicomponent prevention reduces POD but requires substantial resources. The effect of single interventions derived from multicomponent programs remains e…
View article: Attitudes towards chiropractic: a survey of Canadian sport and exercise medicine physicians
Attitudes towards chiropractic: a survey of Canadian sport and exercise medicine physicians Open
View article: Cannabis consumption and motor vehicle collision: A systematic review and meta-analysis of observational studies
Cannabis consumption and motor vehicle collision: A systematic review and meta-analysis of observational studies Open
CRD42022357478.
View article: Patient Perceptions Towards Reduction or Avoidance of Opioids After Knee and Hip Arthroplasty: A Cross-Sectional Survey
Patient Perceptions Towards Reduction or Avoidance of Opioids After Knee and Hip Arthroplasty: A Cross-Sectional Survey Open
Background and objective Opioid analgesics are routinely prescribed to manage pain after total joint arthroplasty (TJA) but are associated with several adverse effects. There is a scarcity of literature exploring patients' receptivity, att…
View article: Metaresearch on patient-reported outcomes in trial protocols and results publications suggested large outcome reporting bias
Metaresearch on patient-reported outcomes in trial protocols and results publications suggested large outcome reporting bias Open
Less than half of RCT protocols with planned PROs reported them as specified in corresponding published results, suggesting outcome reporting bias, and PRO reporting quality was often deficient. These limitations complicate informed decisi…
View article: Impact of the COVID-19 Pandemic and the 2021 National Institute for Health and Care Excellence Guidelines on Public Perspectives Toward Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Thematic and Sentiment Analysis on Twitter (Rebranded as X)
Impact of the COVID-19 Pandemic and the 2021 National Institute for Health and Care Excellence Guidelines on Public Perspectives Toward Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Thematic and Sentiment Analysis on Twitter (Rebranded as X) Open
Background Myalgic encephalomyelitis (ME), also referred to as chronic fatigue syndrome (CFS), is a complex illness that typically presents with disabling fatigue and cognitive and functional impairment. The etiology and management of ME/C…
View article: Chronic pain and healthcare education in Canada: Bridging the divide
Chronic pain and healthcare education in Canada: Bridging the divide Open
Chronic pain and healthcare education in Canada: Bridging the divide Hansel Lui from the Michael G. DeGroote Institute for Pain Research and Care discusses inadequacies in healthcare education regarding chronic pain management in Canada an…
View article: Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis
Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis Open
Background Up to 15% of survivors of COVID-19 infection experience long-term health effects, including fatigue, myalgia and impaired cognitive function, termed post-COVID-19 condition or long COVID. Several trials that study the benefits a…
View article: An exploration of the increasing prevalence of chronic pain among Canadian veterans: Life After Service Studies 2016 and 2019
An exploration of the increasing prevalence of chronic pain among Canadian veterans: Life After Service Studies 2016 and 2019 Open
The increase in chronic pain among Canadian veterans from 2016 to 2019 appears confounded by increased comorbidities associated with chronic pain among responders in 2019.
View article: Reasons for declining to participate in a trial of online cognitive behavioural therapy following orthopaedic trauma: A mixed methods study
Reasons for declining to participate in a trial of online cognitive behavioural therapy following orthopaedic trauma: A mixed methods study Open
The timely enrollment of study participants is critical to the success of clinical trials. Understanding factors that contribute to patients’ decision to participate in trials involving online cognitive behavioural therapy for pain managem…
View article: Cognitive Behavioural Therapy to Optimize Post-Operative Recovery (COPE): a randomized controlled feasibility trial in extremity fracture patients
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery (COPE): a randomized controlled feasibility trial in extremity fracture patients Open
gov/ct2/show/NCT04274530 .
View article: Creativity research in medicine and nursing: A scoping review
Creativity research in medicine and nursing: A scoping review Open
Background Creativity fuels societal progress and innovation, particularly in the field of medicine. The scientific study of creativity in medicine is critical to understanding how creativity contributes to medical practice, processes, and…
View article: Predictors of Response to Medical Cannabis for Chronic Pain: A Retrospective Review of Real-Time Observational Data
Predictors of Response to Medical Cannabis for Chronic Pain: A Retrospective Review of Real-Time Observational Data Open
Objective: People living with chronic pain increasingly use medical cannabis for symptom relief. We conducted a retrospective cohort study examining cannabis for chronic pain relief using anonymous archival data obtained from the medicinal…
View article: A consensus definition of creativity in surgery: A Delphi study protocol
A consensus definition of creativity in surgery: A Delphi study protocol Open
Introduction Clear definitions are essential in science, particularly in the study of abstract phenomena like creativity. Due to its inherent complexity and domain-specific nature, the study of creativity has been complicated, as evidenced…
View article: Interventions for the management of long covid (post-covid condition): living systematic review
Interventions for the management of long covid (post-covid condition): living systematic review Open
Objective To compare the effectiveness of interventions for the management of long covid (post-covid condition). Design Living systematic review. Data sources Medline, Embase, CINAHL, PsycInfo, Allied and Complementary Medicine Database, a…
View article: Treatment decision-making factors among patients with cervical myelopathy: a discrete-choice experiment
Treatment decision-making factors among patients with cervical myelopathy: a discrete-choice experiment Open
Background Degenerative Cervical Myelopathy is a debilitating condition and current recommendations encourage shared decision-making between surgeons and patients. However, there is limited data on patients’ values and preferences for surg…
View article: Traditional, complementary and integrative medicine therapies for the treatment of mild/moderate acute COVID-19: protocol for a systematic review and network meta-analysis
Traditional, complementary and integrative medicine therapies for the treatment of mild/moderate acute COVID-19: protocol for a systematic review and network meta-analysis Open
Background Increasing evidence has emerged for traditional, complementary and integrative medicine (TCIM) to treat COVID-19 which requires systematic summaries of the net benefits of interventions against standard care and one another. The…
View article: Characteristics of creative individuals: An umbrella review protocol
Characteristics of creative individuals: An umbrella review protocol Open
Introduction The properties of creative products–novelty and usefulness–are generally agreed upon by researchers. Yet, consensus is lacking on which personal and environmental factors contribute to an individual’s creative potential, or to…