Jason Wyse
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View article: Bayesian Variable Selection in Distributed Lag Models: A Focus on Binary Quantile and Count Data Regressions
Bayesian Variable Selection in Distributed Lag Models: A Focus on Binary Quantile and Count Data Regressions Open
Distributed Lag Models (DLMs) and similar regression approaches such as MIDAS have been used for many decades in econometrics and more recently to investigate how poor air quality adversely affects human health. In this paper we describe h…
View article: Did physical activity and associated barriers change during COVID-19 restrictions in Ireland? Repeated cross-sectional study
Did physical activity and associated barriers change during COVID-19 restrictions in Ireland? Repeated cross-sectional study Open
Summary This repeated cross-sectional study investigated physical activity and associated barriers and facilitators during the first two waves of COVID-19 restrictions in Ireland. An online, anonymous questionnaire collated data from adult…
View article: Statistical power in vitamin D randomized control trials investigating biomarkers as continuous outcomes
Statistical power in vitamin D randomized control trials investigating biomarkers as continuous outcomes Open
It has long been suspected that mean vitamin D level and differences among individuals in the population might deteriorate power in vitamin D randomised controlled trials (RCTs). However, standard statistical planning tools cannot accommod…
View article: An age-structured SEIR model for COVID-19 incidence in Dublin, Ireland with framework for evaluating health intervention cost
An age-structured SEIR model for COVID-19 incidence in Dublin, Ireland with framework for evaluating health intervention cost Open
Strategies adopted globally to mitigate the threat of COVID–19 have primarily involved lockdown measures with substantial economic and social costs with varying degrees of success. Morbidity patterns of COVID–19 variants have a strong asso…
View article: Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes
Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes Open
Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by ac…
View article: Gaussian Processes to speed up MCMC with automatic exploratory-exploitation effect
Gaussian Processes to speed up MCMC with automatic exploratory-exploitation effect Open
We present a two-stage Metropolis-Hastings algorithm for sampling probabilistic models, whose log-likelihood is computationally expensive to evaluate, by using a surrogate Gaussian Process (GP) model. The key feature of the approach, and t…
View article: The Association Between Ambient UVB Dose and ANCA-associated Vasculitis Relapse and Onset
The Association Between Ambient UVB Dose and ANCA-associated Vasculitis Relapse and Onset Open
Background The etiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differences between granuloma…
View article: The Clinical Application of Urine Soluble CD163 in ANCA-Associated Vasculitis
The Clinical Application of Urine Soluble CD163 in ANCA-Associated Vasculitis Open
Significance Statement In ANCA-associated vasculitis (AAV), noninvasive biomarkers of active renal inflammation, such as urinary soluble CD163, are needed for early detection of active disease before irreversible end organ damage occurs. C…
View article: Time and belief in exercise importance predict increased activity during initial COVID-19 restrictions in Ireland
Time and belief in exercise importance predict increased activity during initial COVID-19 restrictions in Ireland Open
Summary The aim of this work was to investigate physical activity levels and the associated barriers and facilitators to physical activity in Irish adults during initial COVID-19 restrictions. Members of the general population completed an…
View article: Publisher Correction: Power determination in vitamin D randomised control trials and characterising factors affecting it through a novel simulation-based tool
Publisher Correction: Power determination in vitamin D randomised control trials and characterising factors affecting it through a novel simulation-based tool Open
The original version of this Article contained an error in the Introduction section, where, “The tools discussed in this paper are easily used through the undefined R package SimVitD 26 available on the Comprehensive R Archive Network (CRA…
View article: Power determination in vitamin D randomised control trials and characterising factors affecting it through a novel simulation-based tool
Power determination in vitamin D randomised control trials and characterising factors affecting it through a novel simulation-based tool Open
Thousands of observational studies have linked vitamin D deficiency with numerous diseases, but randomised controlled trials (RCTs) often fail to show benefit of supplementation. Population characteristics and trial design have long been s…
View article: Investigation of Type I Interferon Responses in ANCA-Associated Vasculitis
Investigation of Type I Interferon Responses in ANCA-Associated Vasculitis Open
Type I interferon (IFN) dysregulation is a major contributory factor in the development of several autoimmune diseases, termed type I interferonopathies, and is thought to be the pathogenic link with chronic inflammation in these condition…
View article: Investigation of Type I Interferon Responses in ANCA-Associated Vasculitis
Investigation of Type I Interferon Responses in ANCA-Associated Vasculitis Open
Type I interferon (IFN) dysregulation is a major contributory factor in the development of several autoimmune diseases, termed type I interferonopathies, and is thought to be the pathogenic link with chronic inflammation in these condition…
View article: An age-structured SEIR model for COVID-19 incidence in Dublin, Ireland with framework for evaluating health intervention cost
An age-structured SEIR model for COVID-19 incidence in Dublin, Ireland with framework for evaluating health intervention cost Open
Strategies adopted globally to mitigate the threat of COVID–19 have primarily involved lock-down measures with substantial economic and social costs with varying degrees of success. Morbidity patterns of COVID–19 variants have a strong ass…
View article: Increases in DXA-Derived Visceral Fat Across One Season in Professional Rugby Union Players: Importance of Visceral Fat Monitoring in Athlete Body Composition Assessment
Increases in DXA-Derived Visceral Fat Across One Season in Professional Rugby Union Players: Importance of Visceral Fat Monitoring in Athlete Body Composition Assessment Open
Despite regular high-intensive exercise and individually tailored dietary control across a professional rugby season, players from both playing positions demonstrated increases in VAT, although the cause remains unknown. Our findings indic…
View article: Pro-inflammatory Stimulation of Monocytes by ANCA Is Linked to Changes in Cellular Metabolism
Pro-inflammatory Stimulation of Monocytes by ANCA Is Linked to Changes in Cellular Metabolism Open
Clinical and experimental data suggest that pathogenesis in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is driven by ANCA-mediated activation of neutrophils and monocytes. While the role of neutrophils has been extens…
View article: 036. USCD163 IS AN EARLY PREDICTOR OF TREATMENT RESPONSE IN CRESCENTIC GLOMERULONEPHRITIS
036. USCD163 IS AN EARLY PREDICTOR OF TREATMENT RESPONSE IN CRESCENTIC GLOMERULONEPHRITIS Open
Background: Approximately 10-20% of patients with granulomatosis with polyangiitis (GPA) are ANCA-negative.The aim of the study was to compare the clinical characteristics and treatment outcomes of ANCA-positive and ANCA-negative forms of …
View article: Urinary soluble CD163 and monocyte chemoattractant protein-1 in the identification of subtle renal flare in anti-neutrophil cytoplasmic antibody-associated vasculitis
Urinary soluble CD163 and monocyte chemoattractant protein-1 in the identification of subtle renal flare in anti-neutrophil cytoplasmic antibody-associated vasculitis Open
Background Prior work has shown that urinary soluble CD163 (usCD163) displays excellent biomarker characteristics for detection of active renal vasculitis using samples that included new diagnoses with highly active renal disease. This stu…
View article: Bayesian model selection for the latent position cluster model for social networks
Bayesian model selection for the latent position cluster model for social networks Open
The latent position cluster model is a popular model for the statistical analysis of network data. This model assumes that there is an underlying latent space in which the actors follow a finite mixture distribution. Moreover, actors which…
View article: Inferring structure in bipartite networks using the latent blockmodel and exact ICL
Inferring structure in bipartite networks using the latent blockmodel and exact ICL Open
We consider the task of simultaneous clustering of the two node sets involved in a bipartite network. The approach we adopt is based on use of the exact integrated complete likelihood for the latent blockmodel. Using this allows one to inf…
View article: Bayesian model selection for the latent position cluster model for Social Networks
Bayesian model selection for the latent position cluster model for Social Networks Open
The latent position cluster model is a popular model for the statistical analysis of network data. This model assumes that there is an underlying latent space in which the actors follow a finite mixture distribution. Moreover, actors which…
View article: Interlocking directorates in Irish companies using a latent space model for bipartite networks
Interlocking directorates in Irish companies using a latent space model for bipartite networks Open
Significance We develop a statistical model for the evolution of the network of leading Irish company directorates over 11 years, before and after the financial crisis of 2008. We focus on company interlocks, whereby a director simultaneou…