Jasper Callemeyn
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View article: Renal transcriptome-wide analyses in association with kidney black carbon load
Renal transcriptome-wide analyses in association with kidney black carbon load Open
Here, we identified genes and pathways associated with real-life kidney BC particle load, indicating alterations in gene expression involved in assembly and maintenance of primary cilia, the anti-inflammatory properties of the innate immun…
View article: #2731 Legacy effect of pretransplant immunosuppression in kidney transplant recipients with crescentic glomerulonephritis
#2731 Legacy effect of pretransplant immunosuppression in kidney transplant recipients with crescentic glomerulonephritis Open
Background and Aims Kidney transplant recipients with crescentic glomerulonephritis, including ANCA-associated vasculitis (AAV-GN) and anti-glomerular basement disease (GBM-GN), have often received an important burden of immunosuppression …
View article: <i>FCGR3A</i>F158V Genotype Accelerates Progression to Chronic Alloimmune Injury in Antibody-Mediated Kidney Transplant Rejection: A Population-Based Cohort Study
<i>FCGR3A</i>F158V Genotype Accelerates Progression to Chronic Alloimmune Injury in Antibody-Mediated Kidney Transplant Rejection: A Population-Based Cohort Study Open
Background Evidence for involvement of NK cells and monocytes as prime agents in the process of human kidney transplant rejection is expanding quickly. These cells express FCGR3A, used for antibody-dependent cellular cytotoxicity (ADCC) af…
View article: A subset of pro-inflammatory CXCL10+ LILRB2+ macrophages derives from recipient monocytes and drives renal allograft rejection
A subset of pro-inflammatory CXCL10+ LILRB2+ macrophages derives from recipient monocytes and drives renal allograft rejection Open
In solid organ transplantation, monocytes and macrophages play a cross-cutting role in the rejection process, irrespective of the transplanted tissue and the type of rejection. Here, we integrated multiple single-cell assays (>150,000 cell…
View article: Identification and Cross-Platform Validation of Sparse Molecular Classifiers for Antibody-Mediated and T-Cell–Mediated Rejection After Kidney Transplantation
Identification and Cross-Platform Validation of Sparse Molecular Classifiers for Antibody-Mediated and T-Cell–Mediated Rejection After Kidney Transplantation Open
Rigid variable selection strategies can yield sparse molecular classifiers for allograft rejection phenotypes with preserved accuracy and prognostic value across different molecular diagnostic platforms, which may facilitate their interpre…
View article: Expanding the Scope of Microvascular Inflammation: Unveiling Its Presence Beyond Antibody-Mediated Rejection Into T-Cell Mediated Contexts
Expanding the Scope of Microvascular Inflammation: Unveiling Its Presence Beyond Antibody-Mediated Rejection Into T-Cell Mediated Contexts Open
Microvascular inflammation (MVI) in kidney transplant biopsies is mainly associated with antibody-mediated rejection (AMR), sparking debate within the Banff Classification of Renal Allograft Pathology regarding its exclusivity. This study …
View article: Continuous indices to assess the phenotypic spectrum of kidney transplant rejection
Continuous indices to assess the phenotypic spectrum of kidney transplant rejection Open
The international Banff classification for kidney transplant pathology discretizes the rejection continuum into distinct diagnostic categories, introducing artificial dichotomization and threshold effects. To better reflect the underlying …
View article: ANCA-Associated Glomerulonephritis: Diagnosis and Therapy Proceedings of the Henry Shavelle Lectureship
ANCA-Associated Glomerulonephritis: Diagnosis and Therapy Proceedings of the Henry Shavelle Lectureship Open
Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) frequently affects the kidney. Glomerulonephritis (GN) in AAV, ANCA-GN, not only dictates therapeutic decisions but is also of relevance for overall surviv…
View article: Back to the future: the uncharted role of T cells in chronic and unexplained microvascular inflammation
Back to the future: the uncharted role of T cells in chronic and unexplained microvascular inflammation Open
View article: SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys
SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys Open
The steps governing healing with or without fibrosis within the same microenvironment are unclear. After acute kidney injury (AKI), injured proximal tubular epithelial cells activate SOX9 for self-restoration. Using a multimodal approach f…
View article: The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics
The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics Open
View article: Automated Urinary Chemokine Assays for Noninvasive Detection of Kidney Transplant Rejection: A Prospective Cohort Study
Automated Urinary Chemokine Assays for Noninvasive Detection of Kidney Transplant Rejection: A Prospective Cohort Study Open
Urinary chemokines CXCL9 and CXCL10 have been suggested to be good noninvasive biomarkers of kidney transplant rejection. However, defining a context of use and integration with clinical information is necessary before clinical implementat…
View article: Automating kidney transplant rejection diagnosis: a simple solution for a complex problem?
Automating kidney transplant rejection diagnosis: a simple solution for a complex problem? Open
Yoo and colleagues developed the 'Banff automa on system', an automated applica of the Banff Classifica on rules for Kidney Allogra Pathology that uses simple logical opera ons to reach one or several diagnoses 1 .User input consists of hi…
View article: Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection
Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection Open
View article: AKI in a Patient Treated for Herpes Simplex Virus Encephalitis
AKI in a Patient Treated for Herpes Simplex Virus Encephalitis Open
1KU Leuven University Hospitals Leuven: Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, BELGIUM aCorrespondence: Ellen Vandendael E-mail: [email protected] This is an open-access article distribut…
View article: The Banff 2022 Kidney Meeting Report: Re-Appraisal of Microvascular Inflammation and the Role of Biopsy-Based Transcript Diagnostics
The Banff 2022 Kidney Meeting Report: Re-Appraisal of Microvascular Inflammation and the Role of Biopsy-Based Transcript Diagnostics Open
View article: Single-cell mapping of leukocyte immunoglobulin-like receptors in kidney transplant rejection
Single-cell mapping of leukocyte immunoglobulin-like receptors in kidney transplant rejection Open
Leukocyte immunoglobulin-like receptors (LILRs) are a family of inhibitory or stimulatory receptors expressed by immune cell types belonging to both myeloid and lymphoid lineage. Several members of the LILR family recognize major histocomp…
View article: Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection
Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection Open
Rejection remains the main cause of premature graft loss after kidney transplantation, despite the use of potent immunosuppression. This highlights the need to better understand the composition and the interactions of the alloreactive infl…
View article: Association of Predicted HLA T-Cell Epitope Targets and T-Cell–Mediated Rejection After Kidney Transplantation
Association of Predicted HLA T-Cell Epitope Targets and T-Cell–Mediated Rejection After Kidney Transplantation Open
View article: Biological pathways and comparison with biopsy signals and cellular origin of peripheral blood transcriptomic profiles during kidney allograft pathology
Biological pathways and comparison with biopsy signals and cellular origin of peripheral blood transcriptomic profiles during kidney allograft pathology Open
View article: Allorecognition and the spectrum of kidney transplant rejection
Allorecognition and the spectrum of kidney transplant rejection Open
Detection of mismatched human leukocyte antigens by adaptive immune cells is considered as the main cause of transplant rejection, leading to either T-cell mediated rejection or antibody-mediated rejection. This canonical view guided the s…
View article: Integrative Omics Analysis Unravels Microvascular Inflammation-Related Pathways in Kidney Allograft Biopsies
Integrative Omics Analysis Unravels Microvascular Inflammation-Related Pathways in Kidney Allograft Biopsies Open
In solid-organ transplantation, microRNAs (miRNAs) have emerged as key players in the regulation of allograft cells function in response to injury. To gain insight into the role of miRNAs in antibody-mediated rejection, a rejection phenoty…
View article: Risk factors, histopathological features, and graft outcome of transplant glomerulopathy in the absence of donor-specific HLA antibodies
Risk factors, histopathological features, and graft outcome of transplant glomerulopathy in the absence of donor-specific HLA antibodies Open
Transplant glomerulopathy is established as a hallmark of chronic antibody-mediated rejection in kidney transplant patients with donor-specific HLA antibodies (HLA-DSA). The clinical importance of transplant glomerulopathy in the absence o…
View article: Antibodies against ARHGDIB and ARHGDIB gene expression associate with kidney allograft outcome - Supplemental material
Antibodies against ARHGDIB and ARHGDIB gene expression associate with kidney allograft outcome - Supplemental material Open