Jasper E. Bos
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View article: Hemi‐Indigiosin: A pH and Red‐Light Responsive Transmembrane HCl Transporter
Hemi‐Indigiosin: A pH and Red‐Light Responsive Transmembrane HCl Transporter Open
Synthetic anion transporters have emerged as promising therapeutic agents. However, their targeting ability is still low. Herein, we present hemi‐indigiosin, which is structurally related to prodigiosin—a well‐studied natural product exhib…
View article: Hemi‐Indigiosin: A pH and Red‐Light Responsive Transmembrane HCl Transporter
Hemi‐Indigiosin: A pH and Red‐Light Responsive Transmembrane HCl Transporter Open
Synthetic anion transporters have emerged as promising therapeutic agents. However, their targeting ability is still low. Herein, we present hemi‐indigiosin, which is structurally related to prodigiosin—a well‐studied natural product exhib…
View article: Light and protonation-controlled complex formation between sulfate ions and a stiff-stilbene based bis(cyclopeptide)
Light and protonation-controlled complex formation between sulfate ions and a stiff-stilbene based bis(cyclopeptide) Open
A sulfate-binding stiff-stilbene based bis(cyclopeptide) gives rise to 1 : 1, 1 : 2 and 2 : 2 host–guest assemblies, which can be interconverted by light irradiation and acid/base addition.
View article: Control of Bilayer Transport through a Photoswitchable Membrane‐Stiffening Agent
Control of Bilayer Transport through a Photoswitchable Membrane‐Stiffening Agent Open
The mobility of proteins in the bilayer membrane is affected by (local) changes in lipid environment, which is important to their biological functioning. Artificial molecular systems that—to some extent—imitate tasks of membrane‐embedded p…
View article: Control of Bilayer Transport through a Photoswitchable Membrane‐Stiffening Agent
Control of Bilayer Transport through a Photoswitchable Membrane‐Stiffening Agent Open
The mobility of proteins in the bilayer membrane is affected by (local) changes in lipid environment, which is important to their biological functioning. Artificial molecular systems that—to some extent—imitate tasks of membrane‐embedded p…
View article: Activity Control of a Synthetic Transporter by Photodynamic Modulation of Membrane Mobility and Incorporation
Activity Control of a Synthetic Transporter by Photodynamic Modulation of Membrane Mobility and Incorporation Open
Artificial transmembrane transport systems are receiving a great deal of attention for their potential therapeutic application. A major challenge is to switch their activity in response to environmental stimuli, which has been achieved mos…
View article: Photoswitchable Bis(amidopyrroles): Modulating Anion Transport Activity Independent of Binding Affinity
Photoswitchable Bis(amidopyrroles): Modulating Anion Transport Activity Independent of Binding Affinity Open
[Image: see text] Toward photocontrol of anion transport across the bilayer membrane, stiff-stilbene, which has dimethyl substituents in the five-membered rings, is functionalized with amidopyrrole units. UV–vis and (1)H NMR studies show h…
View article: Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors
Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors Open
Anionic species are omnipresent and involved in many important biological processes. A large number of artificial anion receptors has therefore been developed. Some of these are capable of mediating transmembrane transport. However, where …
View article: CCDC 2111230: Experimental Crystal Structure Determination
CCDC 2111230: Experimental Crystal Structure Determination Open
Related Article: Sander J. Wezenberg, Li-Jun Chen, Jasper E. Bos, Ben L. Feringa, Ethan N. W. Howe, Xin Wu, Maxime A. Siegler, Philip A. Gale|2021|J.Am.Chem.Soc.|144|331|doi:10.1021/jacs.1c10034
View article: Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas
Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas Open
Membrane transport proteins fulfill important regulatory functions in biology with a common trait being their ability to respond to stimuli in the environment. Various small-molecule receptors, capable of mediating transmembrane transport,…