Jasper Götting
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View article: RNA-interactome capture identifies SRSF3 as a key protein for herpesviral gene expression
RNA-interactome capture identifies SRSF3 as a key protein for herpesviral gene expression Open
The primary mRNA sequence determines its secondary structure and the repertoire of interacting RNA-binding proteins (RBPs). The resulting mRNA ribonucleoprotein complex (mRNP) then influences all stages of the life of an mRNA. Here, we det…
View article: Virology Capabilities Test (VCT): A Multimodal Virology Q&A Benchmark
Virology Capabilities Test (VCT): A Multimodal Virology Q&A Benchmark Open
We present the Virology Capabilities Test (VCT), a large language model (LLM) benchmark that measures the capability to troubleshoot complex virology laboratory protocols. Constructed from the inputs of dozens of PhD-level expert virologis…
View article: In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice
In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice Open
View article: High genetic stability of co-circulating human adenovirus type 31 lineages over 59 years
High genetic stability of co-circulating human adenovirus type 31 lineages over 59 years Open
Type 31 of human adenovirus species A (HAdV-A31) is a significant pathogen primarily associated with diarrhoea in children but also with life-threatening disseminated disease in allogeneic haematopoietic stem cell transplant (HSCT) recipie…
View article: Molecular phylogeny of human adenovirus type 41 lineages
Molecular phylogeny of human adenovirus type 41 lineages Open
Type 41 of human adenovirus species F (HAdV-F41) is a frequent aetiology of gastroenteritis in children, and nosocomial as well as kindergarten outbreaks have been frequently described. In contrast to other HAdV types, HAdV-F41 was not ass…
View article: Molecular Phylogeny of human adenovirus type 41 lineages
Molecular Phylogeny of human adenovirus type 41 lineages Open
Type 41 of human adenovirus species F (HAdV-F41) is a frequent aetiology of gastroenteritis in children, and nosocomial as well as kindergarten outbreaks have been frequently described. In contrast to other HAdV types, HAdV-F41 was not ass…
View article: IFN-β Deficiency Results in Fatal or Demyelinating Disease in C57BL/6 Mice Infected With Theiler’s Murine Encephalomyelitis Viruses
IFN-β Deficiency Results in Fatal or Demyelinating Disease in C57BL/6 Mice Infected With Theiler’s Murine Encephalomyelitis Viruses Open
Type I Interferons (IFN-I) are important inducers of the antiviral immune response and immune modulators. IFN-β is the most highly expressed IFN-I in the central nervous system (CNS). The infection of SJL mice with the BeAn or the DA strai…
View article: A Recombinant System and Reporter Viruses for Papiine Alphaherpesvirus 2
A Recombinant System and Reporter Viruses for Papiine Alphaherpesvirus 2 Open
Primate simplex viruses, including Herpes simplex viruses 1 and 2, form a group of closely related herpesviruses, which establish latent infections in neurons of their respective host species. While neuropathogenic infections in their natu…
View article: Diagnostic Yield and Therapeutic Consequences of Targeted Next-Generation Sequencing in Sporadic Primary Immunodeficiency
Diagnostic Yield and Therapeutic Consequences of Targeted Next-Generation Sequencing in Sporadic Primary Immunodeficiency Open
Introduction: Primary immunodeficiencies (PIDs) are a heterogeneous group of disorders characterized by increased susceptibility to infections, immune dysregulation, and/or malignancy. Genetic studies, especially during the l…
View article: Human cytomegalovirus multiple-strain infections and viral population diversity in haematopoietic stem cell transplant recipients analysed by high-throughput sequencing
Human cytomegalovirus multiple-strain infections and viral population diversity in haematopoietic stem cell transplant recipients analysed by high-throughput sequencing Open
Human cytomegalovirus (HCMV) is an important opportunistic pathogen in allogeneic haematopoietic stem cell transplant (HSCT) recipients. High-throughput sequencing of target-enriched libraries was performed to characterise the diversity of…
View article: Haploflow: strain-resolved de novo assembly of viral genomes
Haploflow: strain-resolved de novo assembly of viral genomes Open
With viral infections, multiple related viral strains are often present due to coinfection or within-host evolution. We describe Haploflow, a deBruijn graph-based assembler for de novo genome assembly of viral strains from mixed sequence s…
View article: Human Cytomegalovirus Genome Diversity in Longitudinally Collected Breast Milk Samples
Human Cytomegalovirus Genome Diversity in Longitudinally Collected Breast Milk Samples Open
Reactivation and shedding of human cytomegalovirus (HCMV) in breast milk during lactation is highly frequent in HCMV-seropositive mothers. This represents a key transmission route for postnatal HCMV infection and can lead to severe disease…
View article: Haploflow: Strain-resolved<i>de novo</i>assembly of viral genomes
Haploflow: Strain-resolved<i>de novo</i>assembly of viral genomes Open
In viral infections often multiple related viral strains are present, due to coinfection or within-host evolution. We describe Haploflow, a de Bruijn graph-based assembler for de novo genome assembly of viral strains from mixed sequence sa…
View article: Supplementary Material for: Diagnostic Yield and Therapeutic Consequences of Targeted Next-Generation Sequencing in Sporadic Primary Immunodeficiency
Supplementary Material for: Diagnostic Yield and Therapeutic Consequences of Targeted Next-Generation Sequencing in Sporadic Primary Immunodeficiency Open
Introduction: Primary immunodeficiencies (PIDs) are a heterogeneous group of disorders characterized by increased susceptibility to infections, immune dysregulation, and/or malignancy. Genetic studies, especially during the l…
View article: Evaluating assembly and variant calling software for strain-resolved analysis of large DNA viruses
Evaluating assembly and variant calling software for strain-resolved analysis of large DNA viruses Open
Infection with human cytomegalovirus (HCMV) can cause severe complications in immunocompromised individuals and congenitally infected children. Characterizing heterogeneous viral populations and their evolution by high-throughput sequencin…
View article: Evaluating assembly and variant calling software for strain-resolved analysis of large DNA-viruses
Evaluating assembly and variant calling software for strain-resolved analysis of large DNA-viruses Open
Infection with human cytomegalovirus (HCMV) can cause severe complications in immunocompromised individuals and congenitally infected children. Characterizing heterogeneous viral populations and their evolution by high-throughput sequencin…
View article: A Fosmid-Based System for the Generation of Recombinant Cercopithecine Alphaherpesvirus 2 Encoding Reporter Genes
A Fosmid-Based System for the Generation of Recombinant Cercopithecine Alphaherpesvirus 2 Encoding Reporter Genes Open
The transmission of Macacine alphaherpesvirus 1 (McHV-1) from macaques, the natural host, to humans causes encephalitis. In contrast, human infection with Cercopithecine alphaherpesvirus 2 (CeHV-2), a closely related alphaherpesvirus from …
View article: Assembly and variant calling results of strain mixtures of HCMV
Assembly and variant calling results of strain mixtures of HCMV Open
The tgz files contain the assembly contigs of 10 different assemblers and variant calling results of 6 callers on the strain mixture dataset of the HCMV virus.
View article: Assembly and variant calling results of strain mixtures of HCMV
Assembly and variant calling results of strain mixtures of HCMV Open
The tgz files contain the assembly contigs of 10 different assemblers and variant calling results of 6 callers on the strain mixture dataset of the HCMV virus.