Jasper Hsu
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iPSC Reprogramming Identifies the Role of Cryptic Drivers in Preleukemic Clonal Evolution Open
Myeloid neoplasms are clonal disorders driven by acquisition of somatic mutations in hematopoietic stem cells (HSCs). HSCs acquire mutations at each cell division, most of which are thought to be effectively neutral, while only recurrent d…
Altered glycosylation in pancreatic cancer and beyond Open
Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers and is projected to soon be the second leading cause of cancer death. Median survival of PDA patients is 6–10 mo, with the majority of diagnoses occurring at later, met…
Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes Open
Myeloid neoplasms, including myelodysplastic syndromes (MDS), are genetically heterogeneous disorders driven by clonal acquisition of somatic mutations in hematopoietic stem and progenitor cells (HPCs). The order of premalignant mutations …
Glucocorticoid Signaling Enhances Expression of Glucose-Sensing Molecules in Immature Pancreatic Beta-Like Cells Derived from Murine Embryonic Stem Cells In Vitro Open
Pluripotent stem cells may serve as an alternative source of beta-like cells for replacement therapy of type 1 diabetes; however, the beta-like cells generated in many differentiation protocols are immature. The maturation of endogenous be…