Explanipedia

Synaptic density deficits in patients with a psychotic disorder and unaffected siblings Open

Monique van der Weijden-Germann, Jesca E. De Jager, Jasper O. Nuninga, Erik F. J. de Vries, Chris W.J. van der Weijden , et al. · 2025

Background Schizophrenia spectrum disorders (SSD) are associated with cognitive dysfunction, which has been linked to excessive synaptic pruning. To disentangle SSDs genetic vulnerability from secondary effects, we investigated synaptic de…

An Anti-Inflammatory Diet and Its Potential Benefit for Individuals with Mental Disorders and Neurodegenerative Diseases—A Narrative Review Open

Sophie M. van Zonneveld, Ellen J. van den Oever, Benno Haarman, Emmy L. Grandjean, Jasper O. Nuninga , et al. · 2024

This narrative review synthesizes current evidence regarding anti-inflammatory dietary patterns and their potential benefits for individuals with mental disorders and neurodegenerative diseases. Chronic low-grade inflammation is increasing…

Shared effects of electroconvulsive shocks and ketamine on neuroplasticity: A systematic review of animal models of depression Open

Jesca E. De Jager, Rutger Boesjes, Gijs H. J. Roelandt, Ilektra Koliaki, Iris E. Sommer , et al. · 2024

Pre-treatment predictors of cognitive side-effects after treatment with electroconvulsive therapy in patients with depression: A multicenter study Open

Dore Loef, Philip van Eijndhoven, Eva van den Munckhof, Adriaan W. Hoogendoorn, Ruby Manten , et al. · 2024

Our findings show that verbal fluency and memory retention are temporarily affected immediately after ECT. Younger patients may be more susceptible to experiencing these acute cognitive side-effects, which seems to be mostly due to a more …

Changes in perfusion, and structure of hippocampal subfields related to cognitive impairment after ECT: A pilot study using ultra high field MRI Open

Julia Van der A, Jesca E. De Jager, Edwin van Dellen, René C.W. Mandl, Metten Somers , et al. · 2023

Interrogating Associations between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness Open

Dore Loef, Jurjen J. Luykx, Bochao Lin, Linda van Diermen, Jasper O. Nuninga , et al. · 2022

Unhealthy diet in schizophrenia spectrum disorders Open

Sophie M. van Zonneveld, Bartholomeus C. M. Haarman, Ellen J. van den Oever, Jasper O. Nuninga, Iris E. Sommer · 2022

Purpose of review The high mortality and prevalence of metabolic syndrome in patients with schizophrenia spectrum disorders (SSD) is maintained by poor diet. This narrative review summarizes recent literature to provide a reflection of cur…

Table of Contents Open

Emanuel Schwarz, Daniel M. Stout, Jessica Bomyea, Katherine E. Burdick, Jurjen J. Luykx , et al. · 2022

Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness Open

Jurjen J. Luykx, Dore Loef, Bochao Lin, Linda van Diermen, Jasper O. Nuninga , et al. · 2021

Shape and volume changes of the superior lateral ventricle after electroconvulsive therapy measured with ultra-high field MRI Open

Jasper O. Nuninga, René C.W. Mandl, Jeroen C.W. Siero, Wendy Nieuwdorp, Sophie M. Heringa , et al. · 2021

The subventricular zone (SVZ) of the lateral ventricles harbors neuronal stem cells in adult mammals. Rodent studies report neurogenic effects in the SVZ of electroconvulsive stimulation. We hypothesize that if this finding translates to d…

The Dentate Gyrus: Its Value for Depression Open

Jasper O. Nuninga, Iris E. Sommer · 2021

Electrically induced neuroplasticity: Exploring the effects of electroconvulsive therapy for depression using high field MRI Open

Jasper O. Nuninga · 2020

Electroconvulsive therapy (ECT) is an effective treatment for severe depression. Unfortunately, ECT has cognitive side effects. In addition, the exact effects of ECT on the brain remain not entirely understood. In this thesis the cognitive…

Clinical Relevance of Brain Changes After Electroconvulsive Therapy: Is There Really No Link at All? Open

Jasper O. Nuninga, René C.W. Mandl, Iris E. Sommer · 2020

Genetic underpinnings of schizophrenia-related electroencephalographical intermediate phenotypes: A systematic review and meta-analysis Open

Jure Hederih, Jasper O. Nuninga, Kristel van Eijk, Edwin van Dellen, Dirk J. A. Smit , et al. · 2020

Although substantial research into genetics of psychotic disorders has been conducted, a large proportion of their genetic architecture has remained unresolved. Electroencephalographical intermediate phenotypes (EIP) have the potential to …

Vasogenic edema versus neuroplasticity as neural correlates of hippocampal volume increase following electroconvulsive therapy Open

Jasper O. Nuninga, René C.W. Mandl, Martijn Froeling, Jeroen C.W. Siero, Metten Somers , et al. · 2020

The decrease in MD in perfusion fraction f suggest that formation of edema nor angiogenesis are responsible for the ECT-induced volume increases in the hippocampus. Also, it supports the hypothesis that hippocampal volume increases might b…

Correction: The dentate gyrus in depression: directions for future research Open

Jasper O. Nuninga, René C.W. Mandl, Iris E. Sommer · 2020

The dentate gyrus in depression: directions for future research Open

Jasper O. Nuninga, René C.W. Mandl, Iris E. Sommer · 2020

Volume Increase of the Dentate Gyrus Induced by Electroconvulsive Therapy Open

Akihiro Takamiya, Jasper O. Nuninga, René C.W. Mandl, Iris E. Sommer, Masaru Mimura , et al. · 2019

Takamiya, Akihiro MD; Nuninga, Jasper O. MSc; Mandl, René C. W. PhD; Sommer, Iris E. C. MD, PhD; Mimura, Masaru MD, PhD; Kishimoto, Taishiro MD, PhD Author Information

Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T Open

Jasper O. Nuninga, René C.W. Mandl, Marco P. Boks, Steven C. Bakker, Metten Somers , et al. · 2019

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