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View article: Region-specific KCC2 rescue by rhIGF-1 and oxytocin in a mouse model of Rett syndrome
Region-specific KCC2 rescue by rhIGF-1 and oxytocin in a mouse model of Rett syndrome Open
Rett syndrome (RTT) is characterized by dysfunction in neuronal excitation/inhibition (E/I) balance, potentially impacting seizure susceptibility via deficits in K + /Cl - cotransporter 2 (KCC2) function. Mice lacking the Methyl-CpG bindin…
View article: Value-guided remapping of sensory circuits by lateral orbitofrontal cortex in reversal learning
Value-guided remapping of sensory circuits by lateral orbitofrontal cortex in reversal learning Open
Flexible decision-making is crucial for adaptive behaviour. Such behaviour in mammals largely relies on the frontal cortex, and specifically, the orbitofrontal cortex (OFC). How OFC neurons encode decision variables and instruct sensory ar…
View article: Operant Assessment of DMTP Spatial Working Memory in Mice
Operant Assessment of DMTP Spatial Working Memory in Mice Open
Working memory (WM) is required to bridge the time between the moment of sensory perception and the usage of the acquired information for subsequent actions. Its frequent and pharmacoresistent impairment in mental health disorders urges th…
View article: Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity
Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity Open
Elevated activity at the output stage of the anterior hippocampus has been described as a physiological endophenotype of schizophrenia, and its development maps onto the transition from the prodromal to the psychotic state. Interventions t…
View article: Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity
Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity Open
Elevated activity at the output stage of the anterior hippocampus has been described as a physiological endophenotype of schizophrenia, and its development maps onto the transition from its prodromal to its psychotic state. Interventions t…