Javad Baharara
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View article: Green synthesis of selenium nanoparticles using <i>Cordia myxa</i> extract and assessment of their cytotoxic and antioxidant properties.
Green synthesis of selenium nanoparticles using <i>Cordia myxa</i> extract and assessment of their cytotoxic and antioxidant properties. Open
The findings indicate that Se-NPs exhibit anticancer activity against Huh-7 cells, as evidenced by the upregulation of Bax, p53, and Caspase3 gene expression. Therefore, it can be asserted that Se-NPs have the potential to eliminate…
View article: Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by Alginate
Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by Alginate Open
Background: In recent years, nanoparticles have gained increasing popularity over traditional physicochemical methods for fighting pathogenic microorganisms. Due to their unique properties, cerium oxide nanoparticles (CeO2 NPs) have recent…
View article: Assessment of the Anti-Cancer Properties of Harmine and Low-Frequency Electromagnetic Field (50 Hz) on Ovarian Cancer Cells (A2780)
Assessment of the Anti-Cancer Properties of Harmine and Low-Frequency Electromagnetic Field (50 Hz) on Ovarian Cancer Cells (A2780) Open
View article: Effect of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells on Ovarian Granulosa Cells of Immature NMRI Mice.
Effect of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells on Ovarian Granulosa Cells of Immature NMRI Mice. Open
Findings of this study indicated that exosomes derived from bone marrow stem cells improved growth of GCs in NMRI mice and they were a good candidate for further clinical studies to improve quality of the assisted reproductive techniques.
View article: Biopreparation of cerium oxide nanoparticles using alginate: Characterization and estimation of antioxidant and its activity against breast cancer cell lines (MCF7)
Biopreparation of cerium oxide nanoparticles using alginate: Characterization and estimation of antioxidant and its activity against breast cancer cell lines (MCF7) Open
Cerium is an important element whose various biomedical properties have been proven. The purpose of the current study was to fabricate cerium oxide nanoparticles (CeO-NPs) using alginate and to investigate their anti-oxidant properties and…
View article: Effect of exosomes derived from rabbit bone marrow mesenchymal stem cells on the expression of collagen, aggrecan, and tumor necrosis factor-alpha genes in nucleus pulposus cells
Effect of exosomes derived from rabbit bone marrow mesenchymal stem cells on the expression of collagen, aggrecan, and tumor necrosis factor-alpha genes in nucleus pulposus cells Open
هدف: در مطالعه حاضر، تغییرات سطح بیان ژنهای کلاژن، اگریکان و فاکتور نکروز دهنده تومور- آلفا در سلولهایNP التهابی تیمار شده با اگزوزوم و اثربخشی اگزوزوم بر کاهش آپوپتوزیس سلولهایNP ملتهب بررسی شد. مواد و روشها: اگزوزومها با روش اولتراس…
View article: Effect of Anthocyanin on Oxidative Stress and Testis Structure in Streptozotocin-Induced Diabetic Rats
Effect of Anthocyanin on Oxidative Stress and Testis Structure in Streptozotocin-Induced Diabetic Rats Open
Objectives: This study aimed to evaluate the effect of anthocyanin on oxidative stress, sperm, and testis structure in diabetic rats induced by streptozotocin (STZ). Materials and Methods: In this experimental research, diabetes was induce…
View article: Effect of Fluorouracil Combined With Harmine on Induction of Apoptosis in Apoptosis Induction in Pancreatic Cancer Cells (AsPC-1) and the Expression of Apoptotic Genes (BAX, P53, Caspase-3, and Caspase-9)
Effect of Fluorouracil Combined With Harmine on Induction of Apoptosis in Apoptosis Induction in Pancreatic Cancer Cells (AsPC-1) and the Expression of Apoptotic Genes (BAX, P53, Caspase-3, and Caspase-9) Open
Objective: Pancreatic cancer is one of the deadliest cancers related to the digestive system in the world. Due to the increasing resistance of cancer cells to chemotherapy and its side effects, there is a need for drugs with fewer side eff…
View article: Angiotensin-converting enzyme inhibitor, Enalapril, inhibits tumor growth and potentiates the antitumor efficacy of 5-FU in colorectal cancer
Angiotensin-converting enzyme inhibitor, Enalapril, inhibits tumor growth and potentiates the antitumor efficacy of 5-FU in colorectal cancer Open
OBJECTIVE: Colorectal cancer (CRC) is among the leading causes of cancer-related death, indicating the need for the identification of novel therapeutic approaches to increase the activity of current therapy or have better efficacy. Angiote…
View article: The effect of cerebrospinal fluid-derived exosomes on neural differentiation of adipose mesenchymal stem cells in alginate hydrogel scaffold
The effect of cerebrospinal fluid-derived exosomes on neural differentiation of adipose mesenchymal stem cells in alginate hydrogel scaffold Open
The effect of cerebrospinal fluid-derived exosomes on neural differentiation of adipose mesenchymal stem cells in alginate hydrogel scaffold
View article: Evaluation of the Potential Effects of Retinol and Alginate/Gelatin-Based Scaffolds on Differentiation Capacity of Mouse Mesenchymal Stem Cells (MSCs) into Retinal Cells
Evaluation of the Potential Effects of Retinol and Alginate/Gelatin-Based Scaffolds on Differentiation Capacity of Mouse Mesenchymal Stem Cells (MSCs) into Retinal Cells Open
The results presented here elucidate that retinol treatment of MSCs grown on alginate scaffolds would promote the mouse ciliary epithelium-derived MSCs to differentiate towards retinal neurons.
View article: Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade
Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade Open
Background: Melanoma is the most serious kind of skin cancer which has significantly increased in recent decades, and the importance of its primary treatment is increased widely. Ficus carica leaves have various therapeutic impact such as …
View article: Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps
Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps Open
Background The incidence of colorectal cancer (CRC) has increased during recent years in Iran and other developing countries. Clinical studies suggest that essential folate dietary intake and moderate deficiency of methylenetetrahydrofolat…
View article: Leukemia- Derived Exosomes Activate Migration and Tumor-Associated Genes in Astrocytes Isolated from Human Brain Tissue
Leukemia- Derived Exosomes Activate Migration and Tumor-Associated Genes in Astrocytes Isolated from Human Brain Tissue Open
Background: In children with lymphoblastic leukemia (ALL), cancerous metastasis to the central nervous system (CNS) is common, but there is insufficient information on this metastasis and cancer progression process. Further, the role of ex…
View article: The effect of exosomes derived from human ovarian epithelial cancer cells on the secretion of AMH and Inhibin in granulosa cells
The effect of exosomes derived from human ovarian epithelial cancer cells on the secretion of AMH and Inhibin in granulosa cells Open
The effect of exosomes derived from human ovarian epithelial cancer cells on the secretion of AMH and Inhibin in granulosa cells
View article: Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps
Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps Open
Background: The incidence of colorectal cancer (CRC) has increased during recent years in Iran and other developing countries. Clinical studies suggest that essential folate dietary intake and moderate deficiency of methylenetetrahydrofola…
View article: Evaluation of the effect of menthol on apoptosis induction and Bax and Bcl2 gene expression in the CT-26 colon cancer cell line
Evaluation of the effect of menthol on apoptosis induction and Bax and Bcl2 gene expression in the CT-26 colon cancer cell line Open
هدف: هدف از این مطالعه بررسی اثرات آپوپتوتیکی منتول بر سلولهای سرطان کولون ردهی CT-26 میباشد. مواد و روشها: در این پژوهش تجربی آزمایشگاهی سلولهای سرطانی کولون ردهی CT-26 با غلظتهای 1 تا 5 میلیمول از منتول بهمدت 24 و 48 ساعت تیمار…
View article: Isolation and Characterization of Exosomes Derived From Breast Cancer MDA-MB-231 Cell Line
Isolation and Characterization of Exosomes Derived From Breast Cancer MDA-MB-231 Cell Line Open
Background: Exosomes are membrane nanovesicles, 30 to 100 nm in diameter, secreted by most cell types. Besides playing many biological roles, especially in cell-cell communication, scientific proof indicated that the pathology of so many h…
View article: Apoptosis Induction with Combined Use of Cisplatin and Fisetin in Cisplatin-Resistant Ovarian Cancer Cells (A2780).
Apoptosis Induction with Combined Use of Cisplatin and Fisetin in Cisplatin-Resistant Ovarian Cancer Cells (A2780). Open
According to the findings of this study, the combined use of cisplatin and Fisetin increases the induction of apoptosis in cisplatin-resistant ovarian cancer cells (A2780); therefore, the combined use of cisplatin and Fisetin can be consid…
View article: Could high serum folate be associated with adverse effects?
Could high serum folate be associated with adverse effects? Open
Folate is an important water-soluble vitamin that is presented naturally in foods in particular vegetables, fruits, and whole grains. To which extent is this vitamin needed in our daily regimen is not fully known. Several studies have indi…
View article: The effect of Cannabis sativa extract on damages induced by electromagnetic fields on ovarian follicle maturation and hormonal surface changes in mice
The effect of Cannabis sativa extract on damages induced by electromagnetic fields on ovarian follicle maturation and hormonal surface changes in mice Open
The effect of Cannabis sativa extract on damages induced by electromagnetic fields on ovarian follicle maturation and hormonal surface changes in mice
View article: Evaluation of Sclerorhachis leptoclada hydroalcoholic extract on glucose and cholesterol levels, triglyceride, Serum HDL and LDL in male diabetic rats
Evaluation of Sclerorhachis leptoclada hydroalcoholic extract on glucose and cholesterol levels, triglyceride, Serum HDL and LDL in male diabetic rats Open
Background and Aim: Diabetes is a metabolic disorder in the body. Sclerorhachis leptoclada belongs to the chicory family, is used to treat aids and cancer due to the antioxidant compounds in the root. Therefore, in this study, the effect o…
View article: Association of MTHFR C677T Variant Genotype with Serum Folate and Vit B12 in Iranian Patients with Colorectal Cancer or Adenomatous Polyps
Association of MTHFR C677T Variant Genotype with Serum Folate and Vit B12 in Iranian Patients with Colorectal Cancer or Adenomatous Polyps Open
Background: The incidence of colorectal cancer (CRC) has increased vigorously during the last decades in Iran and clinical studies suggest that moderate deficiency of methylenetetrahydrofolate reductase (MTHFR ) and essential folate dietar…
View article: Investigation of the Mechanism and Effect of Enalapril, Angiotensin-Converting Enzyme (ACE) Inhibitor, on Proliferation, Apoptosis, and Migration in Colorectal Cancer Cells
Investigation of the Mechanism and Effect of Enalapril, Angiotensin-Converting Enzyme (ACE) Inhibitor, on Proliferation, Apoptosis, and Migration in Colorectal Cancer Cells Open
Background: Colorectal cancer is one of the most common cancers in Iran, and despite high cure rate, it still has high mortality. Some studies have shown that angiotensin-converting enzyme (ACE) inhibitors are effective in treating cancer …
View article: The regenerative properties of the extracted polysaccharide from Brittle star (Ophiocoma erinaceus) on cutaneous wound in male Wistar rat
The regenerative properties of the extracted polysaccharide from Brittle star (Ophiocoma erinaceus) on cutaneous wound in male Wistar rat Open
The regenerative properties of the extracted polysaccharide from Brittle star (Ophiocoma erinaceus) on cutaneous wound in male Wistar rat
View article: Effect of Adipose-Derived Mesenchymal Stem Cell Repair in Nicotine Model Rat: A Femoral Bone Diaphyseal Defect Study
Effect of Adipose-Derived Mesenchymal Stem Cell Repair in Nicotine Model Rat: A Femoral Bone Diaphyseal Defect Study Open
Background: The major function of the bone in the skeletal system is to provide structural support to the body and its vital organs. Many patients suffer from the disability to restore bone lesions following bone fractures during crashes o…
View article: Functionalized cellulose-preyssler heteropolyacid bio-composite: An engineered and green matrix for selective, fast and in–situ preparation of Pd nanostructures: synthesis, characterization and application
Functionalized cellulose-preyssler heteropolyacid bio-composite: An engineered and green matrix for selective, fast and in–situ preparation of Pd nanostructures: synthesis, characterization and application Open
A new and green engineered biocomposite was synthesized by sol–gel method, using different loadings of the Preyssler heterpolyacid (8, 15, 25, 40 and 50 wt%) on the functionalized microcrystaline cellulose surface. For the first time, this…
View article: Investigation apoptotic effects of silver nanoparticles coated with Achillea biebersteinii extract on A2780 ovarian cancer cells
Investigation apoptotic effects of silver nanoparticles coated with Achillea biebersteinii extract on A2780 ovarian cancer cells Open
Investigation apoptotic effects of silver nanoparticles coated with Achillea biebersteinii extract on A2780 ovarian cancer cells
View article: Effects of titanium dioxide nanoparticles (TiO2) on germination and seedling growth of Vitex plants (Vitex agnus-castus L.)
Effects of titanium dioxide nanoparticles (TiO2) on germination and seedling growth of Vitex plants (Vitex agnus-castus L.) Open
Different concentrations of nanoparticles impose impact different effects on germination and plant growth. The purpose of this study was to investigate the effects of 11 different concentrations of titanium dioxide nanoparticles on germina…
View article: The synergistic influence of the sea cucumber (Holothuria arenicola) extract and dacarbazine on murine melanoma cancer cells B16F10
The synergistic influence of the sea cucumber (Holothuria arenicola) extract and dacarbazine on murine melanoma cancer cells B16F10 Open
Skin cancer has been reported as a contemporary malignant cancer. Here, anti-cancer effects of sea cucumber extract (SCE) from Holothuria arenicola have been examined on melanoma cells and compared with imidazole carboxamide (Dacarbazine) …