Javier Bermejo
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View article: Integrated multi-modal data analysis for computational modeling of healthy and location-dependent myocardial infarction conditions in porcine hearts
Integrated multi-modal data analysis for computational modeling of healthy and location-dependent myocardial infarction conditions in porcine hearts Open
Porcine hearts are widely used for preclinical cardiac evaluation. Computational models, by effectively integrating comprehensive experimental data, often reinforce this preclinical assessment. Using extensive multi-modal data, we develope…
View article: IOTA-Based Authentication for IoT Devices in Satellite Networks
IOTA-Based Authentication for IoT Devices in Satellite Networks Open
View article: The Role of the BMPR2 Pathway in Group-II Pulmonary Hypertension Secondary to Valve Heart Disease
The Role of the BMPR2 Pathway in Group-II Pulmonary Hypertension Secondary to Valve Heart Disease Open
View article: Sympathectomy in refractory ventricular arrhythmias in patients with left ventricular assist device: a grand round case report
Sympathectomy in refractory ventricular arrhythmias in patients with left ventricular assist device: a grand round case report Open
Background Ventricular tachycardias (VTs) are a life-threatening complication of patients with end-stage left ventricular dysfunction, and are a frequent cause for considering advanced therapies. Their management in patients supported by a…
View article: Validation of noninvasive indices of right ventricular diastolic function. Simultaneous echocardiography and pressure-volume catheterization studies
Validation of noninvasive indices of right ventricular diastolic function. Simultaneous echocardiography and pressure-volume catheterization studies Open
View article: Atrial Fibrillation Treatment Stratification Based on Artificial Intelligence‐Driven Analysis of the Electrophysiological Complexity
Atrial Fibrillation Treatment Stratification Based on Artificial Intelligence‐Driven Analysis of the Electrophysiological Complexity Open
Background Atrial Fibrillation (AF) treatment strategies are suboptimal and clinical predictors of success are limited. Artificial Intelligence (AI) has arisen as a powerful tool for treatment efficacy prediction. Objective We developed an…
View article: Metodología para desarrollar modelos predictivos de marcha patológica
Metodología para desarrollar modelos predictivos de marcha patológica Open
El desarrollo de modelos computacionales de simulación predictiva de la marcha resulta de gran utilidad a la hora de proponer y analizar dispositivos de asistencia a la marcha. Este trabajo se enmarca en un proyecto de investigación que pr…
View article: Non-invasive identification of deceleration zones in the atria using imageless ECGI: correlation with contact-mapping
Non-invasive identification of deceleration zones in the atria using imageless ECGI: correlation with contact-mapping Open
Background Recent studies suggest that slow conduction velocity (CV) areas are associated with the perpetuation of AF and its recurrence after ablation. Electrocardiographic imaging (ECGI) provides beat-to-beat reconstruction of atrial ele…
View article: Hemodynamics affects factor XI/XII anticoagulation efficacy in patient-derived left atrial models
Hemodynamics affects factor XI/XII anticoagulation efficacy in patient-derived left atrial models Open
The methodology outlined in this study has the potential to enable personalized assessments of coagulation risk and to tailor anticoagulation therapy by analyzing flow dynamics in patient-derived LA models, representing a significant step …
View article: Validation of Noninvasive Indices of Right Ventricular Diastolic Function. Simultaneous Echocardiography and Pressure-volume Catheterization Studies
Validation of Noninvasive Indices of Right Ventricular Diastolic Function. Simultaneous Echocardiography and Pressure-volume Catheterization Studies Open
Background The reliability of the recommended echocardiographic methods for assessing RV diastolic function has been questioned. We aimed to validate noninvasive indices of RV diastolic function, derived from tricuspid Doppler and myocardi…
View article: La selecci�n de la proyecci�n y la sobreestimulaci�n auricular mejoran los resultados precoces en v�lvulas a�rticas autoexpandibles
La selecci�n de la proyecci�n y la sobreestimulaci�n auricular mejoran los resultados precoces en v�lvulas a�rticas autoexpandibles Open
The combination of COP + RAP during self-expanding TAVI improves postoperative screening for conduction disturbances, thus reducing the need for cardiac rhythm monitoring, and the length stay. The COP + RAP strategy improves the short-term…
View article: The role of endomyocardial biopsy for surveillance of cardiac allograft rejection: time to move on?
The role of endomyocardial biopsy for surveillance of cardiac allograft rejection: time to move on? Open
View article: Projection selection and rapid atrial pacing improves early outcomes after self-expanding transcatheter aortic valves
Projection selection and rapid atrial pacing improves early outcomes after self-expanding transcatheter aortic valves Open
Introduction and objectives: Because of the potential need for permanent pacemaker implantation, patients are frequently monitored for days after transcatheter aortic valve implantation (TAVI), particularly when using self-expanding valves…
View article: Flow transport and not ejection fraction determines left ventricular stasis in patients with impaired systolic function
Flow transport and not ejection fraction determines left ventricular stasis in patients with impaired systolic function Open
Background Impaired left ventricular (LV) systolic function is a major risk factor for mural thrombosis and embolism, but LV ejection fraction (EF) poorly predicts these events, suggesting the existence of additional sources of variability…
View article: Multiphysics simulations reveal haemodynamic impacts of patient‐derived fibrosis‐related changes in left atrial tissue mechanics
Multiphysics simulations reveal haemodynamic impacts of patient‐derived fibrosis‐related changes in left atrial tissue mechanics Open
Stroke is a leading cause of death and disability worldwide. Atrial myopathy, including fibrosis, is associated with an increased risk of ischaemic stroke, but the mechanisms underlying this association are poorly understood. Fibrosis modi…
View article: Treatment of functionally nonsignificant vulnerable plaques in multivessel STEMI: design of the VULNERABLE trial
Treatment of functionally nonsignificant vulnerable plaques in multivessel STEMI: design of the VULNERABLE trial Open
Introduction and objectives: The optimal treatment of nonculprit angiographic intermediate lesions (diameter stenosis 40%-69%) in patients with ST-segment elevation myocardial infarction (STEMI) is still unknown. Lesions with fractional fl…
View article: Hemodynamics Affects Factor XI/XII Anticoagulation Efficacy in Patient-Specific Left Atrial Models
Hemodynamics Affects Factor XI/XII Anticoagulation Efficacy in Patient-Specific Left Atrial Models Open
Atrial fibrillation (AF) disrupts the circulation of blood through the left atrium (LA), and may result in relative stasis in the left atrial appendage (LAA), increasing thromboembolic risk. Anticoagulant agents can lower this risk, but cu…
View article: Machine Learning Prediction for Prognosis of Patients With Aortic Stenosis
Machine Learning Prediction for Prognosis of Patients With Aortic Stenosis Open
In patients with AS, a machine learning algorithm predicts outcomes with good accuracy, and prognostic characteristics were identified. The model can potentially guide risk factor modification and clinical decisions to improve patient prog…
View article: Tratamiento de placas vulnerables funcionalmente no significativas en el IAMCEST multivaso: dise�o del estudio VULNERABLE
Tratamiento de placas vulnerables funcionalmente no significativas en el IAMCEST multivaso: dise�o del estudio VULNERABLE Open
This is the first randomized trial of OCT-guided treatment of vulnerables plaques. Registered at ClinicalTrials.gov (NCT05599061).
View article: La imagen de estasis predice el riesgo de eventos cardioembólicos tras el infarto agudo de miocardio: el estudio ISBITAMI
La imagen de estasis predice el riesgo de eventos cardioembólicos tras el infarto agudo de miocardio: el estudio ISBITAMI Open
Tras el infarto agudo de miocardio con elevación del segmento ST (IAMCEST), los biomarcadores por imagen pueden ser útiles para guiar la anticoagulación oral en la prevención primaria de la cardioembolia. Nuestro objetivo es probar la efic…
View article: Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy
Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy Open
Patients with nonischemic dilated cardiomyopathy (NIDCM) are at higher risk of stroke than their age-matched population. However, the risk of bleeding neutralizes the benefit of preventive oral anticoagulation. In this work, we show that i…
View article: Effectiveness of smoking cessation intervention based on the ABC Approach in patients with TB
Effectiveness of smoking cessation intervention based on the ABC Approach in patients with TB Open
SETTINGUrban setting in the Philippines.OBJECTIVETo assess the effectiveness of the ABC Approach developed by The Union as a tobacco-smoking cessation intervention for TB patients at a primary healthcare level in an urban setting in the Ph…
View article: Multi-physics simulations reveal hemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics
Multi-physics simulations reveal hemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics Open
Stroke is a leading cause of death and disability worldwide. Atrial myopathy, including fibrosis, is associated with an increased risk of ischemic stroke, but the mechanisms underlying this association are poorly understood. Fibrosis modif…
View article: Stasis imaging predicts the risk of cardioembolic events related to acute myocardial infarction: the ISBITAMI study
Stasis imaging predicts the risk of cardioembolic events related to acute myocardial infarction: the ISBITAMI study Open
In patients with STEMI and left ventricular systolic dysfunction in sinus rhythm, the risk of cardioembolism may be assessed by echocardiography by combining stasis and strain imaging. Registered at ClinicalTrials.gov (NCT02917213).
View article: Revealing intracavitary catheter positions: artificial intelligence-enhanced localization with an electrogram-driven variational autoencoder model
Revealing intracavitary catheter positions: artificial intelligence-enhanced localization with an electrogram-driven variational autoencoder model Open
Background The acquisition of electroanatomical (EA) maps in clinical electrophysiology procedures typically depends on locating intracardiac mapping catheters through magnetic triangulation with external patches placed on the patient's sk…
View article: Imageless electrocardiographic imaging for atrial electrophysiological characterization: a validation study
Imageless electrocardiographic imaging for atrial electrophysiological characterization: a validation study Open
Background The mechanisms responsible for atrial fibrillation (AF) are not yet fully understood and treatment strategies remain suboptimal. Electrocardiographic imaging (ECGi) could provide new insights into the arrhythmogenic substrate’s …
View article: Super-resolution Left Ventricular Flow and Pressure Mapping by Navier-Stokes-Informed Neural Networks
Super-resolution Left Ventricular Flow and Pressure Mapping by Navier-Stokes-Informed Neural Networks Open
Intraventricular vector flow mapping (VFM) is a growingly adopted echocardiographic modality that derives time-resolved two-dimensional flow maps in the left ventricle (LV) from color-Doppler sequences. Current VFM models rely on kinematic…
View article: Sudden cardiac death triggered by minimal alcohol consumption in the context of novel PPA2 mutations in 2 unrelated families
Sudden cardiac death triggered by minimal alcohol consumption in the context of novel PPA2 mutations in 2 unrelated families Open
Biallelic variants in PPA2 gene cause a rare but lethal mitochondrial disorder. We describe the first four cases reported in Spain of PPA2 disease in two unrelated families. We have conducted a revision of the clinical history, necropsies,…
View article: Cardiac Stasis Imaging, Stroke and Silent Brain Infarcts in Patients with Non-Ischemic Dilated Cardiomyopathy
Cardiac Stasis Imaging, Stroke and Silent Brain Infarcts in Patients with Non-Ischemic Dilated Cardiomyopathy Open
Background Cardioembolic stroke is one of the most devastating complications of non-ischemic dilated cardiomyopathy (NIDCM). However, in clinical trials of primary prevention, the benefits of anticoagulation were hampered by the risk of bl…
View article: Impact of the Mediterranean Diet on the Gut Microbiome of a Well-Defined Cohort of Healthy Individuals
Impact of the Mediterranean Diet on the Gut Microbiome of a Well-Defined Cohort of Healthy Individuals Open
A comprehensive understanding of gut microbiota in a clearly defined group of healthy individuals is essential when making meaningful comparisons with various diseases. The Mediterranean diet (MD), renowned for its potential health benefit…