Javier Bracchiglione
YOU?
Author Swipe
View article: GRADE concept paper 9: rationale and process for creating a GRADE Ontology
GRADE concept paper 9: rationale and process for creating a GRADE Ontology Open
The rate of research production is increasing exponentially. It is therefore becoming increasingly important to quickly, efficiently, and unambiguously communicate the judgments made and processes used when doing research and using evidenc…
View article: Incorporating patients in the development of clinical practice guidelines
Incorporating patients in the development of clinical practice guidelines Open
Clinical practice guidelines are a set of recommendations developed systematically and based on the best available evidence. Their purpose is to enable healthcare providers and patients to make the best decisions regarding healthcare inter…
View article: Users’ experience of frameworks to support evidence-informed decision-making in public health: a scoping review
Users’ experience of frameworks to support evidence-informed decision-making in public health: a scoping review Open
Background Evidence-informed decision-making in public health (PH) is a complex process requiring the consideration of multiple perspectives and contextual factors. Evidence-to-decision (EtD) frameworks are structured approaches aiming to …
View article: Frameworks to support evidence-informed decision-making in public health and infectious disease prevention and control: a scoping review
Frameworks to support evidence-informed decision-making in public health and infectious disease prevention and control: a scoping review Open
Background Evidence-informed public health decision-making (EIDM) is a complex process that must consider multiple factors. Aim We aimed to identify and describe existing frameworks supporting evidence-informed public health decision-makin…
View article: Applications of Artificial Intelligence in clinical decision-making and technical support in Oncology: A Scoping Review protocol
Applications of Artificial Intelligence in clinical decision-making and technical support in Oncology: A Scoping Review protocol Open
Introduction The management of cancer care generates vast amounts of data, collected in the clinical registry; however, the interpretation of these unstandardized and heterogeneous records is often challenging. Artificial intelligence (AI)…
View article: Short versus long drug regimens for Chagas disease
Short versus long drug regimens for Chagas disease Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of short versus long drug regimens (trypanocidal schemes) for Chagas disease in chronic asymptomatic stages.
View article: Empirical evidence of observer bias in randomized clinical trials: updated and expanded analysis of trials with both blinded and non-blinded outcome assessors
Empirical evidence of observer bias in randomized clinical trials: updated and expanded analysis of trials with both blinded and non-blinded outcome assessors Open
In a randomized clinical trial, the person evaluating the results (assessor) may be either unaware of the intervention received by participants (blinded assessor) or aware of it (non-blinded assessor). Knowing which treatment a patient rec…
View article: Immunotherapy or Targeted Therapy Versus Best Supportive Care for Advanced Gastric Cancer: A Systematic Review and Meta-analysis of Randomized Trials
Immunotherapy or Targeted Therapy Versus Best Supportive Care for Advanced Gastric Cancer: A Systematic Review and Meta-analysis of Randomized Trials Open
View article: Grade Concept Paper: Creating a Grade Ontology
Grade Concept Paper: Creating a Grade Ontology Open
View article: Empirical Evidence of Observer Bias in Randomised Clinical Trials: Updated and Expanded Analysis of Trials with Blinded and Non-Blinded Outcome Assessors
Empirical Evidence of Observer Bias in Randomised Clinical Trials: Updated and Expanded Analysis of Trials with Blinded and Non-Blinded Outcome Assessors Open
View article: Lack of pragmatic attitude of self-labelled pragmatic trials on manual therapy: a methodological review
Lack of pragmatic attitude of self-labelled pragmatic trials on manual therapy: a methodological review Open
View article: Use of the patient-centered outcome Days Alive and Out of Hospital in clinical studies on perioperative care: a scoping review protocol
Use of the patient-centered outcome Days Alive and Out of Hospital in clinical studies on perioperative care: a scoping review protocol Open
Background Various studies across different settings have validated Days Alive and Out of Hospital (DAOH) as a valuable outcome for clinical research in surgery and other fields. However, there is no clear consensus on the definitions and …
View article: Utilising systematic reviews to assess potential overtreatment and claim for better evidence-based research: an analysis of anticancer drugs versus supportive care in advanced esophageal cancer
Utilising systematic reviews to assess potential overtreatment and claim for better evidence-based research: an analysis of anticancer drugs versus supportive care in advanced esophageal cancer Open
View article: Immunotherapy or targeted therapy versus best supportive care for advanced gastric cancer: a systematic review and meta-analysis of randomized trials
Immunotherapy or targeted therapy versus best supportive care for advanced gastric cancer: a systematic review and meta-analysis of randomized trials Open
Purpose To assess the efficacy and safety of non-chemotherapy anticancer drugs (ACDs) compared to best supportive care (BSC) or placebo for the treatment of advanced gastric cancer (GC). Methods Systematic review of randomized controlled t…
View article: Anti-cancer drugs versus supportive care for advanced biliary tract cancers: a systematic review
Anti-cancer drugs versus supportive care for advanced biliary tract cancers: a systematic review Open
Introduction Biliary tract cancers (BTCs) have low survival rates in advanced stages. Anticancer drugs (ACDs) are usually recommended, but may be associated with important toxicity and lower quality of life (QoL). Best supportive care (BSC…
View article: Key factors in the choice of appropriate outcomes for clinical trials
Key factors in the choice of appropriate outcomes for clinical trials Open
Health research is the foundation of medical knowledge and healthcare system recommendations. Therefore, choosing appropriate outcomes in studies of therapeutic interventions is a fundamental step in producing evidence and, subsequently, f…
View article: Pharmacological treatments for adults with overweight and obesity without diabetes
Pharmacological treatments for adults with overweight and obesity without diabetes Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the comparative efficacy and safety of weight‐loss drugs, provided in addition to lifestyle modification, for weight management in adults wit…
View article: Anticancer Drugs Compared to No Anticancer Drugs in Patients with Advanced Hepatobiliary Cancer: A Mapping Review and Evidence Gap Map
Anticancer Drugs Compared to No Anticancer Drugs in Patients with Advanced Hepatobiliary Cancer: A Mapping Review and Evidence Gap Map Open
Patient-important outcomes beyond survival in advanced HBCs are insufficiently assessed by the available evidence. Future studies need to address these gaps to better inform decision-making processes.
View article: Lack of pragmatic attitude of self-labelled pragmatic trials on manual therapy: A methodological review
Lack of pragmatic attitude of self-labelled pragmatic trials on manual therapy: A methodological review Open
Background Pragmatic randomized controlled trials are getting more interest to improve trials external validity. This study aimed to assess how pragmatic the design of the self-labelled pragmatic randomised controlled trials in the manual …
View article: Methodological and users' surveys on the use of the <scp>LILACS</scp> database in Cochrane reviews identified desirable improvements to the database
Methodological and users' surveys on the use of the <span>LILACS</span> database in Cochrane reviews identified desirable improvements to the database Open
Background Latin American and Caribbean Health Sciences Literature (LILACS) is the main reference database in the region; however, the way in which this resource is used in Cochrane systematic reviews has not been studied. Objectives To as…
View article: Treatment with anticancer drugs for advanced pancreatic cancer: a systematic review
Treatment with anticancer drugs for advanced pancreatic cancer: a systematic review Open
View article: Patients’ and informal caregivers’ perspectives on self-management interventions for type 2 diabetes mellitus outcomes: a mixed-methods overview of 14 years of reviews
Patients’ and informal caregivers’ perspectives on self-management interventions for type 2 diabetes mellitus outcomes: a mixed-methods overview of 14 years of reviews Open
View article: Have clinical research and related recommendations been consistent enough for informing the treatment of advanced esophageal cancer patients with anticancer drugs? A critical historical review
Have clinical research and related recommendations been consistent enough for informing the treatment of advanced esophageal cancer patients with anticancer drugs? A critical historical review Open
Purpose to analyse the soundest research and recommendations that have informed the potential superiority of treatments with anticancer drugs over any type of supportive care for advanced esophageal cancer (EC). Methods We conducted a crit…
View article: Anticancer drugs versus supportive care for advanced esophageal cancer: a systematic review of randomized clinical trials and meta-analysis
Anticancer drugs versus supportive care for advanced esophageal cancer: a systematic review of randomized clinical trials and meta-analysis Open
Background Esophageal cancer (EC) is a global health concern and a leading cause of death. A large number of patients are diagnosed with advanced-stage EC, with very poor survival rates Anticancer drugs have limited effectiveness and sever…
View article: Assumptions for creating matrices of evidence to estimate overlap of primary studies in overviews of reviews: Protocol for a meta-research study
Assumptions for creating matrices of evidence to estimate overlap of primary studies in overviews of reviews: Protocol for a meta-research study Open
Introduction Overlap of primary studies among systematic reviews (SRs) included in an overview is a major challenge, as it may bias results or artificially increase the precision of the synthesis. Matrices of evidence and corrected covered…
View article: Approaching the body of evidence: Key concepts of Overviews
Approaching the body of evidence: Key concepts of Overviews Open
The increasing production of primary research and literature reviews in the last decades has made it necessary to develop a new methodological design to synthesize the evidence: the overviews. An overview is a type of evidence synthesis th…
View article: Comparative analysis of systemic oncological treatments and best supportive care for advanced gastresophageal cancer: A comprehensive scoping review and evidence map
Comparative analysis of systemic oncological treatments and best supportive care for advanced gastresophageal cancer: A comprehensive scoping review and evidence map Open
Objective To identify, describe, and organize the available evidence regarding systemic oncological treatments compared to best supportive care (BSC) for advanced gastresophageal cancer. Methods We conducted a thorough search across MEDLIN…
View article: Patients’ and caregivers’ perspectives on outcomes of self-management interventions for type 2 diabetes mellitus: an overview of reviews
Patients’ and caregivers’ perspectives on outcomes of self-management interventions for type 2 diabetes mellitus: an overview of reviews Open
Population Medicine considers the following types of articles:• Research Papers -reports of data from original research or secondary dataset analyses.• Review Papers -comprehensive, authoritative, reviews within the journal's scope.These i…
View article: Frameworks to support evidence-informed decision-making from a public health perspective
Frameworks to support evidence-informed decision-making from a public health perspective Open
BackgroundEvidence-to-Decision (EtD) frameworks enable to consider critical criteria for decision-making. EtD frameworks with a public health perspective have not been systematically evaluated, and their application in the infectious disea…
View article: Systemic Oncological Treatments versus Supportive Care for Patients with Advanced Hepatobiliary Cancers: An Overview of Systematic Reviews
Systemic Oncological Treatments versus Supportive Care for Patients with Advanced Hepatobiliary Cancers: An Overview of Systematic Reviews Open
Background: The trade-off between systemic oncological treatments (SOTs) and UPSC in patients with primary advanced hepatobiliary cancers (HBCs) is not clear in terms of patient-centred outcomes beyond survival. This overview aims to asses…