Javier Cotignola
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View article: Genetic characterization of pediatric B-cell acute lymphoblastic leukemia in Argentina uncovers molecular heterogeneity and novel variants
Genetic characterization of pediatric B-cell acute lymphoblastic leukemia in Argentina uncovers molecular heterogeneity and novel variants Open
Introduction Acute lymphoblastic leukemia is the most common childhood cancer, yet its diagnosis and risk classification remain incomplete in many regions due to limited access to molecular studies. Methods We present the first comprehensi…
View article: PKA-driven SPP1 activation as a novel mechanism connecting the bone microenvironment to prostate cancer progression
PKA-driven SPP1 activation as a novel mechanism connecting the bone microenvironment to prostate cancer progression Open
Prostate cancer (PCa) bone metastasis (BM) poses a significant clinical challenge due to the heterogeneity of treatment responses and patient outcomes. In this study, we examined the role of Protein Kinase A (PKA) signaling in modulating t…
View article: Data from Association of Inherited Genetic Variants with Multiple Primary Melanoma
Data from Association of Inherited Genetic Variants with Multiple Primary Melanoma Open
Background:Recent genome-wide association studies (GWAS) have identified new susceptibility loci for melanoma, but their associations with multiple primary melanoma (MPM) are unclear.Methods:We investigated the associations of 69 SNPs in 3…
View article: Supplementary Table S1 from Association of Inherited Genetic Variants with Multiple Primary Melanoma
Supplementary Table S1 from Association of Inherited Genetic Variants with Multiple Primary Melanoma Open
Supplementary Table S1 shows SNP information and their associations with MPM relative to SPM in the GEM study.
View article: Supplementary Table S3 from Association of Inherited Genetic Variants with Multiple Primary Melanoma
Supplementary Table S3 from Association of Inherited Genetic Variants with Multiple Primary Melanoma Open
Supplementary Table S3 shows the genotype associations with multiple primary melanoma stratified by phenotypic index and back nevi in the GEM study.
View article: Supplementary Table S4 from Association of Inherited Genetic Variants with Multiple Primary Melanoma
Supplementary Table S4 from Association of Inherited Genetic Variants with Multiple Primary Melanoma Open
Supplementary Table S4 shows the estimated effects of SNPs on gene expression in human skin samples.
View article: Supplementary Table S2 from Association of Inherited Genetic Variants with Multiple Primary Melanoma
Supplementary Table S2 from Association of Inherited Genetic Variants with Multiple Primary Melanoma Open
Supplementary Table S2 shows detailed information of 68 independent SNPs identified in the Landi et al. 2020 GWAS.
View article: Sex differences in melanoma survival—a GEM study
Sex differences in melanoma survival—a GEM study Open
Sex differences in melanoma are prominent, with female having a significant survival advantage. However, it is unclear why we see this survival advantage. Here, we investigate the relationship between sex, clinicopathologic variables, and …
View article: AR (CAG)n Microsatellite and APEX1 c.444T>G (p.Asp148Glu) Polymorphisms as Independent Prognostic Biomarkers in Prostate Cancer: Insights from an Argentinian Cohort
AR (CAG)n Microsatellite and APEX1 c.444T>G (p.Asp148Glu) Polymorphisms as Independent Prognostic Biomarkers in Prostate Cancer: Insights from an Argentinian Cohort Open
Background/Objectives: Prostate cancer (PCa) is the leading malignancy and the third most common cause of cancer-related death in Argentinian men. Predicting outcomes in localized PCa remains difficult due to tumor heterogeneity. In this s…
View article: Unmasking Neuroendocrine Prostate Cancer with a Machine Learning-Driven Seven-Gene Stemness Signature That Predicts Progression
Unmasking Neuroendocrine Prostate Cancer with a Machine Learning-Driven Seven-Gene Stemness Signature That Predicts Progression Open
Prostate cancer (PCa) poses a significant global health challenge, particularly due to its progression into aggressive forms like neuroendocrine prostate cancer (NEPC). This study developed and validated a stemness-associated gene signatur…
View article: Unmasking Neuroendocrine Prostate Cancer with a Machine Learning-Driven 7-Gene Stemness Signature that Predicts Progression
Unmasking Neuroendocrine Prostate Cancer with a Machine Learning-Driven 7-Gene Stemness Signature that Predicts Progression Open
Prostate cancer (PCa) poses a significant global health challenge, particularly due to its progression into aggressive forms like neuroendocrine prostate cancer (NEPC). This study developed and validated a stemness-associated gene signatur…
View article: Exploring the Therapeutic Role of CO-RMS: A Novel Perspective on Prostate Cancer Development
Exploring the Therapeutic Role of CO-RMS: A Novel Perspective on Prostate Cancer Development Open
PURPOSE Carbon monoxide (CO) is recognized for its anti-inflammatory, anti-apoptotic, and anti-proliferative properties. The application of carbon monoxide-releasing molecules (CO-RMs) is thus a promising strategy for therapeutic intervent…
View article: Deciphering the Nuclear Role of Heme Oxygenase-1 in Prostate Cancer: Transcriptional Reprogramming and Neuroendocrine Differentiation
Deciphering the Nuclear Role of Heme Oxygenase-1 in Prostate Cancer: Transcriptional Reprogramming and Neuroendocrine Differentiation Open
PURPOSE This study probes the role of Heme Oxygenase-1 (HO-1) and its nuclear interactors in prostate cancer (PCa). Previous results, demonstrated the anti-tumoral role of HO-1 in PCa and its nuclear translocation, hinting at its potential…
View article: The role of miR-34a-5p, PRR11 and SURf4 as potential biomarkers in B-acute lymphoblastic leukemia cells
The role of miR-34a-5p, PRR11 and SURf4 as potential biomarkers in B-acute lymphoblastic leukemia cells Open
Despite advancements in B-cell acute lymphoblastic leukemia (B-ALL) therapy, a significant number of patients still experience treatment resistance, leading to relapse and poor prognosis. Recent studies have revealed the importance of non-…
View article: The role of miR-34a-5p, PRR11 and SURf4 as potential biomarkers in B-acute lymphoblastic leukemia cells
The role of miR-34a-5p, PRR11 and SURf4 as potential biomarkers in B-acute lymphoblastic leukemia cells Open
Despite advancements in B-cell acute lymphoblastic leukemia (B-ALL) therapy, a significant number of patients still experience treatment resistance, leading to relapse and poor prognosis. Recent studies have revealed the importance of non-…
View article: Data Supplement from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice
Data Supplement from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice Open
Table S1: Genesets enriched in PC3.pGIPZ xenografts. Table S2: Genesets enriched in PC3.shCtBP1 xenografts. Supplemental Figure 1: (A) Crystal violet stained NIH3T3 cells foci transfected with pcDNA3.CtBP1 or beta-gal expression vectors. (…
View article: Supplementary Methods, Figures 1 - 6, Tables 1 - 2 from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice
Supplementary Methods, Figures 1 - 6, Tables 1 - 2 from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice Open
PDF file - 556K, Table S1: Genesets enriched in PC3.pGIPZ xenografts. Table S2: Genesets enriched in PC3.shCtBP1 xenografts. Supplemental Figure 1: (A) Crystal violet stained NIH3T3 cells foci transfected with pcDNA3.CtBP1 or beta-gal expr…
View article: Data from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice
Data from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice Open
Purpose: Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality. C-terminal–binding protein 1 (CtBP1) is a transcription repressor of tumor …
View article: Data Supplement from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice
Data Supplement from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice Open
Table S1: Genesets enriched in PC3.pGIPZ xenografts. Table S2: Genesets enriched in PC3.shCtBP1 xenografts. Supplemental Figure 1: (A) Crystal violet stained NIH3T3 cells foci transfected with pcDNA3.CtBP1 or beta-gal expression vectors. (…
View article: Supplementary Methods, Figures 1 - 6, Tables 1 - 2 from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice
Supplementary Methods, Figures 1 - 6, Tables 1 - 2 from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice Open
PDF file - 556K, Table S1: Genesets enriched in PC3.pGIPZ xenografts. Table S2: Genesets enriched in PC3.shCtBP1 xenografts. Supplemental Figure 1: (A) Crystal violet stained NIH3T3 cells foci transfected with pcDNA3.CtBP1 or beta-gal expr…
View article: Data from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice
Data from Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice Open
Purpose: Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality. C-terminal–binding protein 1 (CtBP1) is a transcription repressor of tumor …
View article: Coronavirus pathogenesis in mice explains the SARS-CoV-2 multi-organ spread by red blood cells hitch-hiking
Coronavirus pathogenesis in mice explains the SARS-CoV-2 multi-organ spread by red blood cells hitch-hiking Open
SARS-CoV-2 infection causes a multisystemic disease that affects numerous organs beyond the respiratory system. Thus, it is well known that COVID-19 is associated with a wide range of hematological disorders; however, it remains unclear ho…
View article: Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection
Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection Open
Interferon gamma (IFN-γ) may be potential adjuvant immunotherapy for COVID-19 patients. In this work, we assessed gene expression profiles associated with the IFN-γ pathway in response to SARS-CoV-2 infection. Employing a case-control stud…
View article: Pin-pointing the key hubs in the IFN-γ pathway responding to SARS-CoV-2 infection
Pin-pointing the key hubs in the IFN-γ pathway responding to SARS-CoV-2 infection Open
Interferon gamma may be a potential adjuvant immunotherapy for COVID-19 patients. In this work, we assessed gene expression profiles associated with the IFN-γ pathway in response to SARS-CoV-2 infection. Employing a case-control study from…
View article: Identification of Prognostic Markers in Argentinian Acute Lymphoblastic Leukemia Pediatric Patients Through Transcriptome Analysis: Differential Gene Expression, Mutational Status and Immune Microenvironment
Identification of Prognostic Markers in Argentinian Acute Lymphoblastic Leukemia Pediatric Patients Through Transcriptome Analysis: Differential Gene Expression, Mutational Status and Immune Microenvironment Open
PURPOSE Acute lymphoblastic leukemia (ALL) is the most incident pediatric cancer. Although considerable progress has been made on treatment efficacy and survival rates, 15%-30% of patients relapse and/or die. We aimed to identify molecular…
View article: Exploiting Interdata Relationships in Prostate Cancer Proteomes: Clinical Significance of HO-1, HSPB1, DDB1 and 14-3-3ζ/δ Interaction
Exploiting Interdata Relationships in Prostate Cancer Proteomes: Clinical Significance of HO-1, HSPB1, DDB1 and 14-3-3ζ/δ Interaction Open
PURPOSE Prostate cancer (PCa) is the second most common type of cancer in men and the sixth leading cause of cancer-related death in men worldwide. The discovery of new therapeutic avenues in PCa, and the development of effective drugs in …
View article: Modulation of Metastasis and Stemness-Associated Genes by Heme Oxygenase 1 (HO-1) in Prostate Cancer
Modulation of Metastasis and Stemness-Associated Genes by Heme Oxygenase 1 (HO-1) in Prostate Cancer Open
PURPOSE Prostate cancer stem cells enhance the tumor's capacity to proliferate, metastasize, and to resist therapies. Thus, stemness represents a therapeutic challenge in prostate cancer (PCa). We have previously reported a strong anti-tum…
View article: Long Non-Coding RNAs (lncRNAs) Dysregulated in Tumor Progression to Castration-Resistant Prostate Cancer
Long Non-Coding RNAs (lncRNAs) Dysregulated in Tumor Progression to Castration-Resistant Prostate Cancer Open
PURPOSE The dysregulation of non-coding RNAs is implicated in the development and progression of different pathological processes, including cancer. Prostate cancer is known for having a wide spectrum of clinical outcomes, ranging from an …