Javier del Pino
YOU?
Author Swipe
View article: Cholinergic Transmission Dysregulation and Neurodegeneration Induced by Thyroid Signaling Disruption Following Butylparaben Single and Repeated Treatment
Cholinergic Transmission Dysregulation and Neurodegeneration Induced by Thyroid Signaling Disruption Following Butylparaben Single and Repeated Treatment Open
Butylparaben (BP), a widely used preservative, was implicated in cognitive impairment, though its neurotoxic mechanisms remain elusive. Basal forebrain cholinergic neurons (BFCN) are selectively lost in dementias, contributing to cognitive…
View article: An Unusual Case of Pylephlebitis With the Involvement of Portal and Superior Mesenteric Veins
An Unusual Case of Pylephlebitis With the Involvement of Portal and Superior Mesenteric Veins Open
Pylephlebitis is a low-incidence condition worldwide, more commonly affecting the adult population. Its clinical presentation is nonspecific, thus requiring a detailed clinical history and confirmation through imaging studies (contrast-enh…
View article: Thyroid Hormone Neuroprotection Against Perfluorooctane Sulfonic Acid Cholinergic and Glutamatergic Disruption and Neurodegeneration Induction
Thyroid Hormone Neuroprotection Against Perfluorooctane Sulfonic Acid Cholinergic and Glutamatergic Disruption and Neurodegeneration Induction Open
Background: Perfluorooctane sulfonic acid (PFOS), a widely used industrial chemical, was reported to induce memory and learning process dysfunction. Some studies tried to reveal the mechanisms that mediate these effects, but how they are p…
View article: Imidacloprid unique and repeated treatment produces cholinergic transmission disruption and apoptotic cell death in SN56 cells
Imidacloprid unique and repeated treatment produces cholinergic transmission disruption and apoptotic cell death in SN56 cells Open
Imidacloprid (IMI), the most widely used worldwide neonicotinoid biocide, produces cognitive disorders after repeated and single treatment. However, little was studied about the possible mechanisms that produce this effect. Cholinergic neu…
View article: Increased Levels of Phosphorylated-P38α Induce WNT/β-Catenin and NGF/P75NTR/TrkA Pathways Disruption and SN56 Cell Death following Single and Repeated Chlorpyrifos Treatment
Increased Levels of Phosphorylated-P38α Induce WNT/β-Catenin and NGF/P75NTR/TrkA Pathways Disruption and SN56 Cell Death following Single and Repeated Chlorpyrifos Treatment Open
Chlorpyrifos (CPF) biocide, exposure to which is mainly produced in the human population through diet, induces several neurotoxic effects. CPF single and repeated exposure induces memory and learning disorders, although the mechanisms that…
View article: Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools
Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools Open
Environmental pollutants’ (EPs) amount and diversity have increased in recent years due to anthropogenic activity. Several neurodegenerative diseases (NDs) are theorized to be related to EPs, as their incidence has increased in a similar w…
View article: Bisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo
Bisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo Open
The widely used plasticizer bisphenol-A (BPA) is well-known for producing neurodegeneration and cognitive disorders, following acute and long-term exposure. Although some of the BPA actions involved in these effects have been unraveled, th…
View article: Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain Open
Cadmium (Cd) produces cognition decline following single and repeated treatment, although the complete mechanisms are still unrevealed. Basal forebrain (BF) cholinergic neurons innervate the cortex and hippocampus, regulating cognition. Cd…
View article: Drowsiness Detection in Drivers with Explainable Artificial Intelligence
Drowsiness Detection in Drivers with Explainable Artificial Intelligence Open
View article: Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ<sub>1–42</sub> and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells
Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ<sub>1–42</sub> and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells Open
Acute and long-term paraquat (PQ) exposure produces hippocampal neurodegeneration and cognition decline. Although some mechanisms involved in these effects were found, the rest are unknown. PQ treatment, for 1 and 14 days, upregulated inte…
View article: Neuroprotective mechanisms of multitarget 7-aminophenanthridin-6(5H)-one derivatives against metal-induced amyloid proteins generation and aggregation
Neuroprotective mechanisms of multitarget 7-aminophenanthridin-6(5H)-one derivatives against metal-induced amyloid proteins generation and aggregation Open
View article: Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption Open
View article: Neuroprotective Action of Multitarget 7-Aminophenanthridin-6(<i>5H</i>)-one Derivatives against Metal-Induced Cell Death and Oxidative Stress in SN56 Cells
Neuroprotective Action of Multitarget 7-Aminophenanthridin-6(<i>5H</i>)-one Derivatives against Metal-Induced Cell Death and Oxidative Stress in SN56 Cells Open
Neurodegenerative diseases have been associated with brain metal accumulation, which produces oxidative stress (OS), matrix metalloproteinases (MMPs) induction, and neuronal cell death. Several metals have been reported to downregulate bot…
View article: Aryl Hydrocarbon Receptor Activation Produces Heat Shock Protein 90 and 70 Overexpression, Prostaglandin E2/Wnt/β-Catenin Signaling Disruption, and Cell Proliferation in MCF-7 and MDA-MB-231 Cells after 24 h and 14 Days of Chlorpyrifos Treatment
Aryl Hydrocarbon Receptor Activation Produces Heat Shock Protein 90 and 70 Overexpression, Prostaglandin E2/Wnt/β-Catenin Signaling Disruption, and Cell Proliferation in MCF-7 and MDA-MB-231 Cells after 24 h and 14 Days of Chlorpyrifos Treatment Open
The biocide chlorpyrifos (CPF) was described to increase breast cancer risk in humans, to produce breast cancer in animals, and to induce cell proliferation in MCF-7 and MDA-MB-231 cells after 1 and 14 days of treatment. The entire mechani…
View article: Aprendizaje global, flexible y personalizado para atender la diversidad en el aula, mediante el uso de Flipped Learning, a través del uso integrado de un sistema virtual de respuesta en el aula, y otras herramientas TACs digitales
Aprendizaje global, flexible y personalizado para atender la diversidad en el aula, mediante el uso de Flipped Learning, a través del uso integrado de un sistema virtual de respuesta en el aula, y otras herramientas TACs digitales Open
View article: Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity
Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity Open
View article: Aprendizaje flexible y personalizado para atender la diversidad en el aula, mediante el uso del flipped learning (aprendizaje invertido), a través del uso integrado de un sistema virtual de respuesta en el aula, y otras herramientas TACs
Aprendizaje flexible y personalizado para atender la diversidad en el aula, mediante el uso del flipped learning (aprendizaje invertido), a través del uso integrado de un sistema virtual de respuesta en el aula, y otras herramientas TACs Open
Integración de una aplicación informática propia como sistema de respuesta (clicker) y diferentes herramientas TCs para facilitar la evaluación continua de forma personalizada, aumentar la motivación y rendimiento de los estudiantes a bajo…
View article: OP0002 INCIDENCE OF FIRST CARDIOVASCULAR EVENT IN SPANISH PATIENTS WITH CHRONIC INFLAMMATORY RHEUMATIC DISEASES: PROSPECTIVE DATA FROM THE CARMA PROJECT AFTER 5 YEARS OF FOLLOW-UP
OP0002 INCIDENCE OF FIRST CARDIOVASCULAR EVENT IN SPANISH PATIENTS WITH CHRONIC INFLAMMATORY RHEUMATIC DISEASES: PROSPECTIVE DATA FROM THE CARMA PROJECT AFTER 5 YEARS OF FOLLOW-UP Open
View article: Aprendizaje personalizado para facilitar la inserción en el mercado laboral, mediante la gamificación, a través del uso integrado de mundos y sistemas virtuales de respuesta en el aula para dispositivos móviles con acceso a internet
Aprendizaje personalizado para facilitar la inserción en el mercado laboral, mediante la gamificación, a través del uso integrado de mundos y sistemas virtuales de respuesta en el aula para dispositivos móviles con acceso a internet Open
Integración de una aplicación informática propia como sistema de respuesta (clicker) y una aplicación de entorno simulado para facilitar la evaluación continúa de forma personalizada, aumentar la motivación y rendimiento a bajo coste.
View article: FRI0146 SURVIVAL OF JAK INHIBITORS: REAL-WORLD DATA FROM THE BIOBADASER III REGISTRY
FRI0146 SURVIVAL OF JAK INHIBITORS: REAL-WORLD DATA FROM THE BIOBADASER III REGISTRY Open
View article: Aprendizaje flexible y personalizado para atender la diversidad en el aula, mediante la gamificación, a través del uso integrado de un sistema virtual de respuesta en el aula para dispositivos móviles con acceso a internet y una aplicación de screencasting
Aprendizaje flexible y personalizado para atender la diversidad en el aula, mediante la gamificación, a través del uso integrado de un sistema virtual de respuesta en el aula para dispositivos móviles con acceso a internet y una aplicación de screencasting Open
View article: Transgneic Endothelin 3 Regulates Murine Pigment Production and Coat Color
Transgneic Endothelin 3 Regulates Murine Pigment Production and Coat Color Open
Pigmentation plays a protective role against damage caused by ultraviolet (UV) irradiation. Humans with fair skin and light hair have a higher susceptibility to UV-induced DNA damage that can lead to the development of skin cancers. The me…
View article: Aprendizaje colaborativo/competitivo mediante gamificación, a través del uso integrado de un mando wiimote como pizarra digital interactiva, un sistema virtual de respuesta en el aula, y dispositivos móviles con acceso a internet
Aprendizaje colaborativo/competitivo mediante gamificación, a través del uso integrado de un mando wiimote como pizarra digital interactiva, un sistema virtual de respuesta en el aula, y dispositivos móviles con acceso a internet Open
Integración de pizarra digital, una aplicación informática propia como sistema de respuesta (clicker) y otras aplicaciones no propias para facilitar la evaluación continua, aumentar la motivación y rendimiento de los estudiantes a un coste…
View article: Amitraz changes NE, DA and 5-HT biosynthesis and metabolism mediated by alterations in estradiol content in CNS of male rats
Amitraz changes NE, DA and 5-HT biosynthesis and metabolism mediated by alterations in estradiol content in CNS of male rats Open
View article: Effects of sex hormones disruption, after prenatal and postnatal exposure to chlordimeform, on monoaminergic neurotransmitters systems in female and male rat’s prefrontal cortex
Effects of sex hormones disruption, after prenatal and postnatal exposure to chlordimeform, on monoaminergic neurotransmitters systems in female and male rat’s prefrontal cortex Open
Introduction: Chlordimeform, as well as other formamidine pesticides, has been described to induce permanent sex- and region-dependent effects on development of monoaminergic neurotransmitter systems. The mechanisms that induce these effec…
View article: Upregulation of Antioxidant Enzymes by <scp>ASS</scp>234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy
Upregulation of Antioxidant Enzymes by <span>ASS</span>234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy Open
Alzheimer's disease (AD), a major neurodegenerative disorder, is a matter of health concern because of the lack of effective drugs to treat it. Thus, our group has recently identified N-((5-(3-(1-benzylpiperidin-4-yl) propoxy)-1-methyl-1H-…
View article: Apoptotic and necrotic basal forebrain cholinergic neuronal loss and dendritic spines alteration after acute and long-term chlorpyrifos exposure: Legal implications of the use of toxicogenomic profile as a biomarker of harmful effects induced under subclinical doses
Apoptotic and necrotic basal forebrain cholinergic neuronal loss and dendritic spines alteration after acute and long-term chlorpyrifos exposure: Legal implications of the use of toxicogenomic profile as a biomarker of harmful effects induced under subclinical doses Open
Introducción: El clorpirifos (CPF) es un insecticida organofosforado que tras la exposición aguda y repetida, induce disfunciones de los procesos de aprendizaje y memoria, aunque el mecanismo por el cual se produce este efecto no se conoce…
View article: Prevalencia y determinantes de adherencia a terapia antihipertensiva en pacientes de la Región Metropolitana
Prevalencia y determinantes de adherencia a terapia antihipertensiva en pacientes de la Región Metropolitana Open
Only half of hypertensive patients comply with their antihypertensive therapy.
View article: Permanent sexual and regional noradrenergic and dopaminergic systems impairment after prenatal and postnatal exposure to chlordimeform
Permanent sexual and regional noradrenergic and dopaminergic systems impairment after prenatal and postnatal exposure to chlordimeform Open
Introduction: Formamidines pesticides have been described to induce permanent effects on development of monoaminergic neurotransmitter systems. The mechanisms that induce these effects are not known but it has been suggested that these eff…
View article: Evaluación docente dinámica mediante gamificación, con una red social integrada a un sistema de respuesta en el aula a través de una aplicación en cloud para dispositivos móviles con acceso a internet
Evaluación docente dinámica mediante gamificación, con una red social integrada a un sistema de respuesta en el aula a través de una aplicación en cloud para dispositivos móviles con acceso a internet Open
El presente proyecto pretende mediante el uso de una aplicación informática de desarrollo propio, que integra una red social y clickers, facilitar la evaluación continua y aumentar la motivación y rendimiento de los estudiantes a un coste …