Javier Echeverría
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View article: Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties
Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties Open
Background Chronic nerve pain is a complex and debilitating condition. Considering the complex pathophysiology of chronic nerve pain, researchers aim to develop novel multi-targeting agents. Polydatin (PLD), a natural multi-targeting compo…
View article: Global innovative perspectives and trends on digital health and patient safety: highlights from the #DHPSP2024 networking event
Global innovative perspectives and trends on digital health and patient safety: highlights from the #DHPSP2024 networking event Open
Aim: This manuscript summarizes the key scientific and practical outcomes of the #DHPSP2024 digital networking event, focusing on emerging trends in digital health technologies, innovations in patient safety, and their implications for imp…
View article: Omega-3 fatty acids: dietary components for the promotion of human and animal health
Omega-3 fatty acids: dietary components for the promotion of human and animal health Open
Omega-3 fatty acids, commonly found in fish and other natural sources, are essential polyunsaturated fats with significant health benefits. This study provides an overall quantitative literature analysis on omega-3 fatty acids. Bibliometri…
View article: Upcycling Walnut Green Husk: Polyphenol-Rich Extracts from Traditional vs. Organic Crops for Spray-Dried Vegan Additive Development
Upcycling Walnut Green Husk: Polyphenol-Rich Extracts from Traditional vs. Organic Crops for Spray-Dried Vegan Additive Development Open
This study explores the valorization of walnut green husk, an agro-industrial by-product, through ultrasound-assisted extraction to obtain polyphenol-rich extracts with antioxidant properties. The extracts demonstrated non-cytotoxicity, re…
View article: Intrathecal silymarin administration improves recovery after compression spinal cord injury: evidence for neuroprotection, antioxidant, and anti-inflammatory action
Intrathecal silymarin administration improves recovery after compression spinal cord injury: evidence for neuroprotection, antioxidant, and anti-inflammatory action Open
Background Spinal cord injury (SCI) is a debilitating disorder that affects people’s quality of life. Unfortunately, there is no definitive drug for treating SCI. Additionally, the adverse effects of existing non-approved drugs make it nec…
View article: Menthol–thymol NADES as a fungicidal and chemosensitizing agent against multidrug-resistant Candida albicans: ROS induction, efflux pump inhibition, and synergy with fluconazole
Menthol–thymol NADES as a fungicidal and chemosensitizing agent against multidrug-resistant Candida albicans: ROS induction, efflux pump inhibition, and synergy with fluconazole Open
Background The increasing prevalence of azole-resistant Candida albicans (RCa) poses a critical therapeutic challenge, necessitating innovative antifungal approaches. Natural deep eutectic solvents (NADES), derived from natural metabolites…
View article: Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity
Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity Open
Background The induction of oxidative stress (OS) in host cells by antibiotics (ATBs) such as ciprofloxacin (CIP) and chloramphenicol (CMP) is associated with their side effects. Flavonoids such as quercetin (Q) and luteolin (LT) could cou…
View article: The protective role of curcumin in mitigating drug-induced toxicity in male reproductive system
The protective role of curcumin in mitigating drug-induced toxicity in male reproductive system Open
Background Curcumin, a key bioactive component of turmeric ( Curcuma longa L. [Zingiberaceae]), has gained considerable attention for its potential to mitigate drug-induced toxicity. This review synthesizes and clarifies current findings o…
View article: Integrando ciencia y tradición: desafíos en la regulación de plantas medicinales en Chile
Integrando ciencia y tradición: desafíos en la regulación de plantas medicinales en Chile Open
Si bien el Ministerio de Salud (MINSAL) ha realizado importantes esfuerzos para el control y la regulación del uso de plantas medicinales en Chile, se requiere un trabajo mancomunado entre todos los actores involucrados. A pesar de la exis…
View article: 3D-QSAR Design of New Bcr-Abl Inhibitors Based on Purine Scaffold and Cytotoxicity Studies on CML Cell Lines Sensitive and Resistant to Imatinib
3D-QSAR Design of New Bcr-Abl Inhibitors Based on Purine Scaffold and Cytotoxicity Studies on CML Cell Lines Sensitive and Resistant to Imatinib Open
Background/Objectives: Bcr-Abl inhibitors such as imatinib have been used to treat chronic myeloid leukemia (CML). However, the efficacy of these drugs has diminished due to mutations in the kinase domain, notably the T315I mutation. There…
View article: Neuroprotective effects of astaxanthin in a scopolamine-induced rat model of Alzheimer’s disease through antioxidant/anti-inflammatory pathways and opioid/benzodiazepine receptors: attenuation of Nrf2, NF-κB, and interconnected pathways
Neuroprotective effects of astaxanthin in a scopolamine-induced rat model of Alzheimer’s disease through antioxidant/anti-inflammatory pathways and opioid/benzodiazepine receptors: attenuation of Nrf2, NF-κB, and interconnected pathways Open
Background Given the complexity of pathological mechanisms behind Alzheimer’s disease (AD), there is a pressing need for novel multi-targeting therapeutic agents. Astaxanthin, a natural compound with diverse biological effects, has emerged…
View article: Pre-Hispanic ritual use of psychoactive plants at Chavín de Huántar, Peru
Pre-Hispanic ritual use of psychoactive plants at Chavín de Huántar, Peru Open
Ritual is broadly accepted as an important locus of social interaction in the pre-Hispanic Central Andes, and research into the development of durable sociopolitical inequality in the region often focuses on the social and political roles …
View article: Exploring the neuroprotective potential of naringin following spinal cord injury in rats: improving sensory and motor function through combating inflammation and oxidative stress
Exploring the neuroprotective potential of naringin following spinal cord injury in rats: improving sensory and motor function through combating inflammation and oxidative stress Open
Introduction Spinal cord injury (SCI) leads to widespread cascades of inflammatory and oxidative factors. This pathological condition damages nerves and causes neurological disorders. To address these complex conditions, it is important to…
View article: Chromene flavanones from Dalea boliviana as xanthine oxidase inhibitors: in vitro biological evaluation and molecular docking studies
Chromene flavanones from Dalea boliviana as xanthine oxidase inhibitors: in vitro biological evaluation and molecular docking studies Open
Background Prenylated flavanones represent a structurally diverse class of natural compounds with significant biological potential. Among them, chromene flavanones (CFs) constitute a rare and specialized subgroup with promising therapeutic…
View article: Polydatin attenuates Alzheimer’s disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects
Polydatin attenuates Alzheimer’s disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects Open
Background Considering the complex pathophysiological mechanisms behind Alzheimer’s disease (AD), a few drugs for managing related cognitive symptoms have been approved. The phytochemical resveratrol has shown promising anti-inflammatory a…
View article: Evaluating the anti-neuropathic effects of the thymol-loaded nanofibrous scaffold in a rat model of spinal cord injury
Evaluating the anti-neuropathic effects of the thymol-loaded nanofibrous scaffold in a rat model of spinal cord injury Open
Background Spinal cord injury (SCI) is a debilitating condition characterized by partial or complete loss of motor and sensory function caused by mechanical trauma to the spinal cord. Novel therapeutic approaches are continuously explored …
View article: Pelargonidin improves functional recovery and attenuates neuropathic pain following spinal cord injury in rats: relevance to its neuroprotective, antioxidant, and anti-inflammatory effects
Pelargonidin improves functional recovery and attenuates neuropathic pain following spinal cord injury in rats: relevance to its neuroprotective, antioxidant, and anti-inflammatory effects Open
Background Spinal cord injury (SCI) significantly impairs individuals’ sensorimotor functions, hindering daily activities. Current therapeutic options often demonstrate limited efficacy and lead to undesirable side effects. Emerging resear…
View article: Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects
Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects Open
Background Spinal cord injury (SCI) is a leading cause of sensorimotor disorders, impacting millions of people globally. The absence of effective treatments and the side effects of existing medications highlight the need for innovative res…
View article: Climate change and the sustainable use of medicinal plants: a call for “new” research strategies
Climate change and the sustainable use of medicinal plants: a call for “new” research strategies Open
Climate change and human activities severely impact the viability of plants and ecosystems, threatening the environment, biodiversity, and the sustainable development of plant-based products. Biotic and abiotic (ecosystem) determinants aff…
View article: Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar
Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar Open
Background Growing reports are dedicated to providing novel agents for wound healing with fewer adverse effects and higher efficacy. The efficacy of nanofibers composed of polyvinyl alcohol (PVA)/polyethylene oxide (PEO)/chitosan (CS) in p…
View article: Preparation and characterization of Pistacia atlantica oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound
Preparation and characterization of Pistacia atlantica oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound Open
Background A growing body of research is dedicated to developing new therapeutic agents for wound healing with fewer adverse effects. One of the proceedings being taken today in wound healing research is to identify promising biological ma…
View article: Anti-neuropathic effects of astaxanthin in a rat model of chronic constriction injury: passing through opioid/benzodiazepine receptors and relevance to its antioxidant and anti-inflammatory effects
Anti-neuropathic effects of astaxanthin in a rat model of chronic constriction injury: passing through opioid/benzodiazepine receptors and relevance to its antioxidant and anti-inflammatory effects Open
Introduction Neuropathic pain is a debilitating neurological disorder and is on the rise. Since no effective treatment has been so far approved to combat the complex pathological mechanisms behind neuropathic pain, finding new therapeutic …
View article: Fermented beverages in prehispanic Chile: a comprehensive review of their phytochemistry, traditional medicinal uses, bioactivity, and social aspects
Fermented beverages in prehispanic Chile: a comprehensive review of their phytochemistry, traditional medicinal uses, bioactivity, and social aspects Open
Background Archaeological, ethnohistorical, and ethnographic evidence supports the ubiquitous use of fermented beverages in prehispanic Chile. Made from a variety of plant raw materials, these beverages have been of special importance rega…
View article: The genus Haplopappus: botany, phytochemistry, traditional uses, and pharmacological properties
The genus Haplopappus: botany, phytochemistry, traditional uses, and pharmacological properties Open
Background The genus Haplopappus Cass. [Asteraceae] comprises a large number of species distributed mainly in Chile and with various traditional medicinal uses. Purpose The present review addresses the botany, traditional uses, chemistry, …
View article: Chilean papaya (Vasconcellea pubescens A. DC.) residues as a source of bioactive compounds: Chemical composition, antioxidant capacity, and antiglycation effects
Chilean papaya (Vasconcellea pubescens A. DC.) residues as a source of bioactive compounds: Chemical composition, antioxidant capacity, and antiglycation effects Open
The Chilean papaya (Vasconcellea pubescens A.DC.) is a climacteric fruit that grows in the north and center of Chile. During its processing, residues formed mainly by mucilage and seeds are produced and mostly discarded, despite bei…
View article: Natural products for the treatment of allergic rhinitis: focus on cellular signaling pathways and pharmacological targets
Natural products for the treatment of allergic rhinitis: focus on cellular signaling pathways and pharmacological targets Open
Background Allergic rhinitis is an inflammatory disease dependent on immunoglobulin E and causes inflammation of the nasal mucosa, leading to decreased quality of life for affected patients. Since common treatments, including corticosteroi…
View article: Editorial: Natural products and nanoparticles in cancer treatment: is there a light at the end of the tunnel?
Editorial: Natural products and nanoparticles in cancer treatment: is there a light at the end of the tunnel? Open
View article: Polydatin attenuated neuropathic pain and motor dysfunction following spinal cord injury in rats by employing its anti-inflammatory and antioxidant effects
Polydatin attenuated neuropathic pain and motor dysfunction following spinal cord injury in rats by employing its anti-inflammatory and antioxidant effects Open
Background Considering the complex pathological mechanisms behind spinal cord injury (SCI) and the adverse effects of present non-approved drugs against SCI, new studies are needed to introduce novel multi-target active ingredients with hi…
View article: Exudate and Propolis from Escallonia pulverulenta: Phytochemical Characterization and Antibacterial Activity
Exudate and Propolis from Escallonia pulverulenta: Phytochemical Characterization and Antibacterial Activity Open
Propolis is a complex mixture formed from exudates that bees collect from plants and then mix with beeswax and their own salivary enzymes. Chilean propolis is characterized by the presence of phenolic compounds, which are considered respon…
View article: RITUALES DE ENTIERROS DE INFANTES, USO DE PLANTAS SAGRADAS Y BEBIDAS FERMENTADAS EN EL TEMPLETE FORMATIVO DE TULÁN (CIRCUMPUNA DE ATACAMA, NORTE DE CHILE)
RITUALES DE ENTIERROS DE INFANTES, USO DE PLANTAS SAGRADAS Y BEBIDAS FERMENTADAS EN EL TEMPLETE FORMATIVO DE TULÁN (CIRCUMPUNA DE ATACAMA, NORTE DE CHILE) Open
Se destaca la distribución, propiedades y secuencia temporal de la aplicación de vainas de algarrobo y semillas de cebil en diversas regiones andinas en términos de usos ritualizados. Un análisis desde la Circumpuna de Atacama (norte de Ch…