Javier Cervera
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View article: Top-down perspectives on cell membrane potential and protein transcription
Top-down perspectives on cell membrane potential and protein transcription Open
We have explored a simple model for the multicellular interplay between bioelectricity and protein transcription using a top-down perspective that offers new insights complementary to the commonly used bottom-up descriptions. We model the …
Multiple Negative Differential Resistances in Nanofluidic Conical Pores: A Phenomenological Model Open
Ionic flow nonlinear effects are helpful for sensing and signal processing in nanofluidic systems. Here, we develop a simple phenomenological model based on a distribution of Boltzmann-like electrical conductances to describe different for…
High-Dimension Ionic Memory in Oscillating Ion Current Signals Open
Nanopores provide controlled nanoconfinement that can be utilized to induce localized chemical reactions. Here we present a nanopore exhibiting memory in the frequency of ion current oscillations induced by the dynamic formation and remova…
Neuromorphic Reservoir Computing with Memristive Nanofluidic Diodes Open
Memristive systems show conductance states modulated by past electrical stimuli acting as artificial synapses. Most neuromorphic computing systems are based on solid-state memristive devices that use physical environments and electrical ca…
Reversible logic with a nanofluidic memristor Open
A multipore membrane with current-rectifying nanofluidic diodes exhibits memristive properties based on the surface-charge-regulated ionic transport. The neuromorphiclike potentiation of the conductance by voltage pulses provides different…
Oscillatory phenomena in electrophysiological networks: The coupling between cell bioelectricity and transcription Open
Morphogenetic regulation during embryogenesis and regeneration rely on information transfer and coordination between different regions. Here, we explore theoretically the coupling between bioelectrical and transcriptional oscillations at t…
pH-Dependent Effects in Nanofluidic Memristors Open
Multipore membranes with nanofluidic diodes show memristive and current rectifying effects that can be controlled by the nanostructure asymmetry and ionic solution characteristics in addition to the frequency and amplitude of the electrica…
Modeling of memory effects in nanofluidic diodes Open
Nanofluidic diodes and ionic solutions find application in electrochemical circuits for information processing, controlled release, and signal conversion in hybrid devices. Here, we describe a physical model that accounts for the memory ef…
Neuromorphic responses of nanofluidic memristors in symmetric and asymmetric ionic solutions Open
We show that ionic conduction properties of a multipore nanofluidic memristor can be controlled not only by the amplitude and frequency of an external driving signal but also by chemical gating based on the electrolyte concentration, prese…
Synaptical Tunability of Multipore Nanofluidic Memristors Open
We demonstrate a multipore nanofluidic memristor with\nconical pores\nshowcasing a wide range of hysteresis and memristor properties that\nprovide functionalities for brainlike computation in neuromorphic\napplications. Leveraging the inte…
Inductive nanopore synapse element for iontronic neuromorphic computing Open
The rapid expansion of artificial intelligence (AI) technologies necessitates the resolution of data handling and storage limitations inherent in the von Neumann computer architecture. Drawing inspiration from biology, which initially spar…
View article: Biphasic concentration patterns in ionic transport under nanoconfinement revealed in steady-state and time-dependent properties
Biphasic concentration patterns in ionic transport under nanoconfinement revealed in steady-state and time-dependent properties Open
Ion permeation across nanoscopic structures differs considerably from microfluidics because of strong steric constraints, transformed solvent properties, and charge-regulation effects revealed mostly in diluted solutions. However, little i…
Transplantation of fragments from different planaria: A bioelectrical model for head regeneration Open
Head-tail planaria morphologies are influenced by the electric potential differences across the animal's primary axis, as evidenced e.g. by voltage-sensitive dyes and functional experiments that create permanent lines of 2-headed but genet…
Electrical conductance of conical nanopores: Symmetric and asymmetric salts and their mixtures Open
We have studied experimentally the electrical conductance–voltage curves of negatively and positively charged conical nanopores bathed in ionic solutions with monovalent, divalent, and trivalent cations at electrochemically and biologicall…
Fluoride-Induced Negative Differential Resistance in Nanopores: Experimental and Theoretical Characterization Open
We describe experimentally and theoretically the fluoride-induced negative differential resistance (NDR) phenomena observed in conical nanopores operating in aqueous electrolyte solutions. The threshold voltage switching occurs around 1 V …
Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate Open
Electric potential distributions can act as instructive pre-patterns for development, regeneration, and tumorigenesis in cell systems. The biophysical states influence transcription, proliferation, cell shape, migration, and differentiatio…
Morphology changes induced by intercellular gap junction blocking: A reaction-diffusion mechanism Open
Complex anatomical form is regulated in part by endogenous physiological communication between cells; however, the dynamics by which gap junctional (GJ) states across tissues regulate morphology are still poorly understood. We employed a b…
Negative differential resistance and threshold-switching in conical nanopores with KF solutions Open
Negative differential resistance (NDR) phenomena are under-explored in nanostructures operating in the liquid state. We characterize experimentally the NDR and threshold switching phenomena observed when conical nanopores are immersed in t…
Size‐Based Cationic Molecular Sieving through Solid‐State Nanochannels Open
The molecular sieving behavior of soft‐etched polyimide membranes having negatively charged nanochannels is described experimentally and theoretically using alkali metal–crown ether cationic complexes and alkylammonium cations. To this end…