Javier Zamora
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View article: Maternal paracetamol (acetaminophen) use during pregnancy and risk of autism spectrum disorder and attention deficit/hyperactivity disorder in offspring: umbrella review of systematic reviews
Maternal paracetamol (acetaminophen) use during pregnancy and risk of autism spectrum disorder and attention deficit/hyperactivity disorder in offspring: umbrella review of systematic reviews Open
Objective To assess the quality, biases, and validity of evidence on maternal paracetamol (acetaminophen) use during pregnancy and the risk of autism spectrum disorder (referred to as autism) and attention deficit/hyperactivity disorder (A…
View article: Liaison Psychiatry in a Tertiary Care Hospital: Experience of the “20 de Noviembre” National Medical Center
Liaison Psychiatry in a Tertiary Care Hospital: Experience of the “20 de Noviembre” National Medical Center Open
Introduction. Liaison Psychiatry is a key subspecialty in the comprehensive management of hospitalized patients in general hospitals. Its implementation at the Centro Médico Nacional 20 de Noviembre has enabled the approach to medical-psyc…
View article: AI-Enhanced Approaches to Interstitial Lung Disease: A Review of Machine Learning Advances
AI-Enhanced Approaches to Interstitial Lung Disease: A Review of Machine Learning Advances Open
The integration of AI into healthcare has marked a transformative era, with machine learning (ML) playing a pivotal role in reshaping the landscape of interstitial lung disease (ILD) management. ML models excel in analysing complex dataset…
View article: Access to Sexual and Reproductive Health Services for Migrant Women in Colombia: A Mixed Methods Approach
Access to Sexual and Reproductive Health Services for Migrant Women in Colombia: A Mixed Methods Approach Open
Introduction:Migration and forced displacement present critical challenges to sexual and reproductive health (SRH) systems. Colombia hosts over 2.8 million Venezuelan migrants and a high number of internally displaced persons, offering a u…
View article: Effects of maternal education on maternal and perinatal outcomes: An individual participant data meta‐analysis of 2 356 402 pregnancies
Effects of maternal education on maternal and perinatal outcomes: An individual participant data meta‐analysis of 2 356 402 pregnancies Open
Background Maternal and perinatal mortality remain critical indicators of global health inequity. In 2020, an estimated 287 000 women died from preventable causes related to pregnancy, and in 2021, approximately 2.3 million neonatal deaths…
View article: Recognition of the microbial metabolite p-cresol in autism spectrum disorder: systematic review and meta-analysis
Recognition of the microbial metabolite p-cresol in autism spectrum disorder: systematic review and meta-analysis Open
Introduction In recent years, research has focused on the gut-brain axis and its microbial metabolites as potential etiological or physiopathological agents of autism spectrum disorders (ASDs). Elevated levels of the organic compound para …
View article: Time-lapse imaging systems for embryo incubation and assessment to improve reproductive outcomes in women undergoing in vitro fertilisation: study protocol for an individual participant data meta-analysis of randomised controlled trials
Time-lapse imaging systems for embryo incubation and assessment to improve reproductive outcomes in women undergoing in vitro fertilisation: study protocol for an individual participant data meta-analysis of randomised controlled trials Open
Introduction Time-lapse imaging (TLI) systems for embryo incubation and assessment are hypothesised to improve the success rates of in vitro fertilisation (IVF) treatment by providing undisturbed culture conditions for embryos and/or provi…
View article: Recommendations for the use of biomarkers for the management of adults with sepsis: a scoping review and critical appraisal
Recommendations for the use of biomarkers for the management of adults with sepsis: a scoping review and critical appraisal Open
Objective A synthesis and appraisal of the recommendations for biomarkers in practice guidelines concerning sepsis is required to consolidate evidence-based practice. We generated an evidence gap map (EGM) on the use of biomarkers for mana…
View article: Coronavirus-two infection among adults: A scoping review of literature published in 2023-24
Coronavirus-two infection among adults: A scoping review of literature published in 2023-24 Open
Objective: To identify and synthesize evidence on Coronavirus-two infection (SARS-CoV-2) among adults diagnosed by polymerase chain reaction. Methods: The protocol was registered on Open Science Forum (doi: 10.17605/OSF.IO/2837X). Three bi…
View article: Sex as a prognostic factor for mortality in adults with acute symptomatic pulmonary embolism
Sex as a prognostic factor for mortality in adults with acute symptomatic pulmonary embolism Open
The evidence is uncertain about sex (being male or female) as an independent prognostic factor for predicting mortality in adults with PE. We found that, for female patients with PE, there is likely a small but clinically important reducti…
View article: PLA2-R positive primary membranous nephropathy: a case report
PLA2-R positive primary membranous nephropathy: a case report Open
Membranous nephropathy (MN) is a significant cause of nephrotic syndrome in adults, often linked to the presence of circulating antibodies against phospholipase A2 receptor (PLA2R). This case report details the clinical presentation, diagn…
View article: Tuberculosis in adult migrants in Europe: a TBnet consensus statement
Tuberculosis in adult migrants in Europe: a TBnet consensus statement Open
Introduction Global migration has increased in recent decades owing to war, conflict, persecution and natural disasters, but also secondary to increased opportunities related to work or study. Migrants’ risk of tuberculosis (TB) differs de…
View article: Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysis
Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysis Open
Objective To predict birth weight at various potential gestational ages of delivery based on data routinely available at the first antenatal visit. Design Individual participant data meta-analysis. Data sources Individual participant data …
View article: Development and validation of prediction models for fetal growth restriction and birthweight: an individual participant data meta-analysis
Development and validation of prediction models for fetal growth restriction and birthweight: an individual participant data meta-analysis Open
Background Fetal growth restriction is associated with perinatal morbidity and mortality. Early identification of women having at-risk fetuses can reduce perinatal adverse outcomes. Objectives To assess the predictive performance of existi…
View article: Human gut microbiota analysis of cystic fibrosis infants using metaproteomics
Human gut microbiota analysis of cystic fibrosis infants using metaproteomics Open
We report a metaproteomic analysis of the gut microbiota of eight infants with cystic fibrosis, during the first year of life. This is the first study in this disease that uses metaproteomics to analyze stool samples from patients at such …
View article: Optimizing intrauterine insemination: A systematic review and meta‐analysis of the effectiveness and safety of clinical treatment add‐ons
Optimizing intrauterine insemination: A systematic review and meta‐analysis of the effectiveness and safety of clinical treatment add‐ons Open
Introduction Intrauterine insemination (IUI) is one of the most widespread fertility treatments. However, IUI protocols vary significantly amongst fertility clinics. Various add‐on interventions have been proposed to boost success rates. T…
View article: Recommendations for the use of biomarkers for the management of adults with sepsis: a scoping review
Recommendations for the use of biomarkers for the management of adults with sepsis: a scoping review Open
Background Biomarkers are invaluable tools for clinicians to optimise patient care at the bedside. The information derived from clinical guidelines plays a pivotal role in establishing evidence-based practices. However, a synthesis and app…
View article: Selection versus transmission: Quantitative and organismic biology in antibiotic resistance
Selection versus transmission: Quantitative and organismic biology in antibiotic resistance Open
We aimed to determine the importance of selection (mostly dependent on the anthropogenic use of antimicrobials) and transmission (mostly dependent on hygiene and sanitation) as drivers of the spread of antibiotic-resistant bacterial popula…
View article: Post‐publication research integrity concerns in randomized clinical trials: A scoping review of the literature
Post‐publication research integrity concerns in randomized clinical trials: A scoping review of the literature Open
Background Post‐publication handling of integrity concerns in randomized clinical trials (RCTs) is a contentious matter. Objectives We undertook a scoping systematic review to map the literature regarding post‐publication integrity issues …
View article: Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis
Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis Open
Objective To assess the effects of COVID-19 vaccines in women before or during pregnancy on SARS-CoV-2 infection-related, pregnancy, offspring and reactogenicity outcomes. Design Systematic review and meta-analysis. Data sources Major data…
View article: Maternal and perinatal outcomes in twin pregnancies following assisted reproduction: a systematic review and meta-analysis involving 802 462 pregnancies
Maternal and perinatal outcomes in twin pregnancies following assisted reproduction: a systematic review and meta-analysis involving 802 462 pregnancies Open
BACKGROUND ART is associated with higher rates of twin pregnancies than singleton pregnancies. Whether twin pregnancies conceived following ART have additional maternal and neonatal complications compared with non-ART twin pregnancies is n…
View article: Selection versus Transmission: Quantitative and Organismic Biology in Antibiotic Resistance
Selection versus Transmission: Quantitative and Organismic Biology in Antibiotic Resistance Open
We aimed to determine the importance of selection (mostly dependent on the anthropogenic use of antimicrobials) and transmission (mostly dependent on hygiene and sanitation) as drivers of the spread of antibiotic-resistant bacterial popula…
View article: Persistent organic pollutant exposure as a risk factor of gestational diabetes mellitus: A systematic review and meta‐analysis
Persistent organic pollutant exposure as a risk factor of gestational diabetes mellitus: A systematic review and meta‐analysis Open
Background Findings related to the association between persistent organic pollutants (POPs) and gestational diabetes mellitus (GDM) are inconclusive. Objectives To estimate the strength of the association between POP exposure and GDM in a …
View article: Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings
Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings Open
The CAM-ICU tool may have a role in the early identification of delirium, in adult patients hospitalized in intensive care units, including those on mechanical ventilation, when non-specialized, properly trained clinical personnel apply th…