Javier Solana Sánchez
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View article: Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change
Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change Open
Brain atrophy is a key factor behind episodic memory loss in aging, but the nature and ubiquity of this relationship remains poorly understood. This study leverages 13 longitudinal datasets, including 3737 cognitively healthy adults (10,34…
View article: Increasing resilience to stress by home-based transcranial stimulation
Increasing resilience to stress by home-based transcranial stimulation Open
Mental health disorders, especially anxiety and depression, affect nearly one billion people worldwide, with chronic stress playing a major role in their onset and severity. Despite growing demand, access to care remains limited, underscor…
View article: Increasing resilience to stress by home-based transcranial stimulation
Increasing resilience to stress by home-based transcranial stimulation Open
Mental health disorders, especially anxiety and depression, affect nearly one billion people worldwide, with chronic stress playing a major role in their onset and severity. Despite growing demand, access to care remains limited, underscor…
View article: EEG Biomarkers for a Precision-Medicine Approach to Noninvasive Brain Stimulation for Major Depressive Disorder
EEG Biomarkers for a Precision-Medicine Approach to Noninvasive Brain Stimulation for Major Depressive Disorder Open
View article: Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance
Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance Open
Introduction Lifestyle factors have demonstrated a significant contribution to resilience against cognitive decline and age-related diseases. However, the understanding of how combinations of modifiable lifestyle behaviors relate to cognit…
View article: Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes
Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes Open
Differences in the volumes of brain structures between individuals are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains unclear to what extent these differences…
View article: Home-based non-invasive brain stimulation for treatment-resistant depression
Home-based non-invasive brain stimulation for treatment-resistant depression Open
Introduction Depression is a prevalent disease and 30% of affected patients are resistant to pharmacological treatment. Home-Based transcranial Direct Current Stimulation (HB-tDCS) has been proposed as a treatment option due to its low cos…
View article: Vulnerability to memory decline in aging. A mega-analysis of structural brain change.
Vulnerability to memory decline in aging. A mega-analysis of structural brain change. Open
Brain atrophy is a key factor behind episodic memory loss in aging, but the nature and ubiquity of this relationship remains poorly understood. This study leveraged 13 longitudinal datasets, including 3,737 cognitively healthy adults (10,3…
View article: Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries
Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries Open
View article: Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries
Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries Open
Why education is linked to higher cognitive function in aging is fiercely debated. Leading theories propose that education reduces brain decline in aging, enhances tolerance to brain pathology, or that it does not affect cognitive decline …
View article: Associations between purpose in life, well-being, and TMS-EEG induced brain plasticity in cognitively preserved older adults
Associations between purpose in life, well-being, and TMS-EEG induced brain plasticity in cognitively preserved older adults Open
View article: Multilingualism in use and white matter changes amongst healthy middle‐aged and older adults
Multilingualism in use and white matter changes amongst healthy middle‐aged and older adults Open
Background Bilingualism can stimulate brain plasticity (Jafari et al. Ann N Y Acad Sci. 2021;1505(1):8‐22) and is also associated with better executive function (Grundy. J Cult Cogn. Sci. 2020;4: 177–199). We investigated whether any featu…
View article: Psychological profiles associated with cortical thickness changes in middle‐aged adults
Psychological profiles associated with cortical thickness changes in middle‐aged adults Open
Background Psychological factors such as repetitive negative thinking, proneness to experience distress, and perceived stress are associated with increased risk of neurodegeneration and clinical dementia, whereas having a sense of life‐pur…
View article: Exploring PACC5 Associations with Cortical Thickness in Individuals with Subjective Cognitive Decline
Exploring PACC5 Associations with Cortical Thickness in Individuals with Subjective Cognitive Decline Open
Background Individuals with subjective cognitive decline (SCD) express concern about self‐perceived cognitive decline, despite no objective impairment, and are at higher risk of developing Alzheimer’s disease (AD). The preclinical Alzheime…
View article: Spontaneous and perturbation-based EEG cortical excitability markers are associated with plasma p-tau181 concentration in healthy middle-aged adults
Spontaneous and perturbation-based EEG cortical excitability markers are associated with plasma p-tau181 concentration in healthy middle-aged adults Open
In early-stage Alzheimer's disease (AD) amyloid-β (Aβ) deposition can induce neuronal hyperactivity, thereby potentially triggering activity-dependent neuronal secretion of phosphorylated tau (p-tau), ensuing tau aggregation and spread. Th…
View article: Impact of repetitive negative thinking on subjective cognitive decline: insights into cognition and brain structure
Impact of repetitive negative thinking on subjective cognitive decline: insights into cognition and brain structure Open
Introduction Individuals with subjective cognitive decline (SCD) express concern about self-perceived cognitive decline despite no objective impairment and are at higher risk of developing Alzheimer’s disease. Despite documented links betw…
View article: Lifestyle trajectories in middle-aged adults and their relationship with health indicators
Lifestyle trajectories in middle-aged adults and their relationship with health indicators Open
Introduction Understanding the impact of different lifestyle trajectories on health preservation and disease risk is crucial for effective interventions. Methods This study analyzed lifestyle engagement over five years in 3,013 healthy adu…
View article: Functional brain connectivity prior to the <scp>COVID</scp>‐19 outbreak predicts mental health trajectories during two years of pandemic
Functional brain connectivity prior to the <span>COVID</span>‐19 outbreak predicts mental health trajectories during two years of pandemic Open
While acknowledging the hardships caused by COVID-19, the pandemic
\nalso provided a unique opportunity to study mental well-being and individual vulnerability or resilience. Sociodemographic, psychological factors, and lifestyles, have be…
View article: Investigating the application of “Guttmann Cognitest”® in older adults and people with acquired brain injury
Investigating the application of “Guttmann Cognitest”® in older adults and people with acquired brain injury Open
Introduction Digital solutions for cognitive assessment are currently not only widely used in experimental contexts but can also be useful in clinical practice for efficient screening and longitudinal follow-up. The “Guttmann Cognitest” ® …
View article: Lifestyle Trajectories in Middle-Aged Adults and Their Relationship with Health Indicators
Lifestyle Trajectories in Middle-Aged Adults and Their Relationship with Health Indicators Open
View article: “Guttmann Cognitest<sup>®</sup>,” a digital solution for assessing cognitive performance in adult population: A feasibility and usability pilot study
“Guttmann Cognitest<sup>®</sup>,” a digital solution for assessing cognitive performance in adult population: A feasibility and usability pilot study Open
Background As the world population continues to age, the prevalence of neurological diseases, such as dementia, poses a significant challenge to society. Detecting cognitive impairment at an early stage is vital in preserving and enhancing…
View article: Independent living, emotional well-being, and quality of life in people with disabilities: the mediator role of self-determination and satisfaction with participation
Independent living, emotional well-being, and quality of life in people with disabilities: the mediator role of self-determination and satisfaction with participation Open
Background In the field of disability and rehabilitation, participation in society has become an important therapeutic objective due to its potential impact on rehabilitation, prognosis, and patient’s mid and long-term well-being. However,…
View article: Associations between ruminative brooding and white matter change amongst healthy middle‐aged and older adults
Associations between ruminative brooding and white matter change amongst healthy middle‐aged and older adults Open
Background Repetitive Negative Thinking (RNT) includes negative thoughts about the future (worry) and past (ruminative brooding). RNT has been associated with Alzheimer’s disease (AD) pathology (Marchant et al. Alzheimers Dement . 2020;16(…
View article: Spontaneous‐ and Perturbation‐Based Cortical Excitability Markers of Plasma pTau181 Concentrations in Healthy Middle‐aged Adults
Spontaneous‐ and Perturbation‐Based Cortical Excitability Markers of Plasma pTau181 Concentrations in Healthy Middle‐aged Adults Open
Background Alzheimer’s disease is characterized by cortical hyperexcitability in the early stages, which may be attributed to the intricate interplay between tau and amyloid β pathologies. To combat the propagation of tau pathology and cog…
View article: Associations between psychological risk and protective profiles and cognitive status in two independent cohorts
Associations between psychological risk and protective profiles and cognitive status in two independent cohorts Open
Background Positive and negative psychological factors represent pertinent moderators of relative risk and protection for cognitive decline and dementia. For example, repetitive negative thinking has been associated with accelerated cognit…
View article: Remote cognitive assessment to early detection of cognitive decline
Remote cognitive assessment to early detection of cognitive decline Open
View article: Cognitive dispersion as a function of cognitive reserve: influence on cognition and functional connectivity in a healthy middle‐aged population
Cognitive dispersion as a function of cognitive reserve: influence on cognition and functional connectivity in a healthy middle‐aged population Open
Background Cognitive dispersion index (CDI), a measure of intraindividual variability across neuropsychological tests, is considered a sensitive marker of prodromic stages of Alzheimer’s Disease (Halliday et al. J. Intell 2018;6(1):12). CD…
View article: Associations between repetitive negative thinking and segregation of the anterior salience network amongst healthy middle‐aged adults
Associations between repetitive negative thinking and segregation of the anterior salience network amongst healthy middle‐aged adults Open
Background Repetitive Negative Thinking (RNT) includes negative thoughts about the future (worry) and past (rumination), and has been associated with AD physiopathology (Marchant et al. Alzh&Dement 2020;16:1054). Prefrontal and anterior ci…
View article: Brain system segregation and pain catastrophizing in chronic pain progression
Brain system segregation and pain catastrophizing in chronic pain progression Open
Pain processing involves emotional and cognitive factors that can modify pain perception. Increasing evidence suggests that pain catastrophizing (PC) is implicated, through pain-related self-thoughts, in the maladaptive plastic changes rel…
View article: Purpose in life promotes resilience to age-related brain burden in middle-aged adults
Purpose in life promotes resilience to age-related brain burden in middle-aged adults Open