Explanipedia

Toxicological and Antidiabetic Investigation of Albizia zygia (D.C.) Macbr Open

Kolade O. Faloye, Marcus D. Ayoola, Funmilayo G. Famuyiwa, Seun B. Ogundele, Sunday Ayoola Oke , et al. · 2025

Background of the study The global increase in the number of diabetes cases reported yearly is alarming, especially in developing countries. The study assessed the toxicological and antidiabetic effects of the leaf extract of Albizia zygia…

The Dual Burden of Hepatitis B and C Among Drug Users in Asia: The First Systematic Review and Meta-Analysis Open

Ali A. Zaidan, Kizito Eneye Bello, Zaheda H. Radwan, Ammar Hassouneh, Hayam Ali AlRasheed , et al. · 2025

Hepatitis B virus (HBV) and Hepatitis C virus (HCV) contribute significantly to morbidity and mortality among drug users in Asia. This study systematically reviews and analyzes the pooled prevalence of HBV and HCV, considering geographic a…

Epidemiological trends and forecasting of tuberculosis burden in the Gulf Cooperation Council countries: Evidence from global burden of disease 1990–2021 Open

Akashanand Akashanand, Shailesh Kumar Samal, Shilpa Gaidhane, Diptismita Jena, R. Roopashree , et al. · 2025

Unraveling the Antidiabetic Effect of Alternantera brasiliana (L.) Kuntze: A Combined in Vitro and in Vivo Approach Open

Kolade O. Faloye, Funmilayo G. Famuyiwa, Esther A. Olanudun, Marcus D. Ayoola, Peter T. Ayoade , et al. · 2024

Background of the study This study established the antidiabetic efficacy of Alternantera brasiliana in vitro and in vivo, identified the most active fraction and profiled the chemical constituents of the most active fraction. Methodology T…

Exploring the sedative properties of natural molecules from hop cones (Humulus lupulus) as promising natural anxiolytics through GABA receptors and the human serotonin transporter Open

Amany Belal, Mohammed S. Elballal, Ahmed A. Al‐Karmalawy, Ahmed H.E. Hassan, Eun Joo Roh , et al. · 2024

This research work aimed to identify the main components that are responsible for the sedative properties of hop cones and allocate their targets. This investigation was performed through molecular docking, molecular dynamic simulations, r…

Stem cell therapy for COVID-19 treatment: an umbrella review Open

Chaozhi Tang, Arkadiusz Dziedzic, Mahalaqua Nazli Khatib, Saad Alhumaid, Lakshmi Thangavelu , et al. · 2024

Background: COVID-19 has presented significant obstacles to healthcare. Stem cell therapy, particularly mesenchymal stem cells, has emerged as a potential treatment modality due to its immunomodulatory and regenerative properties. This umb…

First parechovirus reported case in Saudi Arabia in hospitalized immunocompromised adult patient Open

Abdullah Alshammari, Jawaher Alotaibi, Reem S. Almaghrabi, Reema Bawazeer, Sahar Althawadi , et al. · 2024

Molecular docking, drug-likeness and DFT study of some modified tetrahydrocurcumins as potential anticancer agents Open

Ahmed Mahal, Marwan Al-Janabi, Volkan Eyüpoğlu, Anas Alkhouri, Samir Chtita , et al. · 2023

First Parechovirus reported case in Saudi Arabia in Hospitalized immunocompromised adult patient. Open

Abdullah Mohammad Alshammari, Jawaher Alotaibi, Reem S. Almaghrabi, Reema A. Bawazeer, Sahar Althawadi , et al. · 2023

Human parechovirus, a member of the Picornaviridae family (PeVs), can lead to severe infections, including severe meningitis, meningoencephalitis, and sepsis-like syndrome. We report a case of human parechovirus-related encephalitis in a 5…

A Review of the Resistance Mechanisms for β-Lactams, Macrolides and Fluoroquinolones among Streptococcus pneumoniae Open

Nurul Izzaty Najwa Zahari, Engku Nur Syafirah Engku Abd Rahman, Ahmad Adebayo Irekeola, Naveed Ahmed, Ali A. Rabaan , et al. · 2023

Streptococcus pneumoniae (S. pneumoniae) is a bacterial species often associated with the occurrence of community-acquired pneumonia (CAP). CAP refers to a specific kind of pneumonia that occurs in individuals who acquire the infection out…

Unleashing the power of artificial intelligence for diagnosing and treating infectious diseases: A comprehensive review Open

Ali A. Rabaan, Muhammed A. Bakhrebah, Jawaher Alotaibi, Zuhair S. Natto, Rahaf S. Alkhaibari , et al. · 2023

Infectious diseases present a global challenge, requiring accurate diagnosis, effective treatments, and preventive measures. Artificial intelligence (AI) has emerged as a promising tool for analysing complex molecular data and improving th…

Human immunodeficiency virus in Saudi Arabia: Current and future challenges Open

Maha Al-Mozaini, Tahani Al-Rahabani, Qais Dirar, Tala Alashgar, Ali A. Rabaan , et al. · 2023

The aim is to offer insight for healthcare policymakers to comply with the UNAIDS 2020 vision program and help establish the prevailing paradigms in the HIV community for an AIDS-free generation and the 90-90-90 goals for diagnosis.

Pharmacological treatment and vaccines in monkeypox virus: a narrative review and bibliometric analysis Open

Muhammad Aaqib Shamim, Prakasini Satapathy, Bijaya Kumar Padhi, Sai Dutt Veeramachaneni, Naushaba Akhtar , et al. · 2023

Mpox (earlier known as monkeypox) virus infection is a recognized public health emergency. There has been little research on the treatment options. This article reviews the specific drugs used to treat mpox virus infection and the vaccines…

Clinical and laboratory characteristics of idiopathic inflammatory myositis in Saudi patients Open

Fahidah Alenzi, Jawaher Alotaibi, Manal Alnasser, Fahdah Alokaily · 2023

In our patients, dermatomyositis was the most common form of myositis, and skin manifestations were the most prevalent clinical characteristics. None of the patients developed a malignancy or died.

Antibacterial Efficacy of N-(4-methylpyridin-2-yl) Thiophene-2-Carboxamide Analogues against Extended-Spectrum-β-Lactamase Producing Clinical Strain of Escherichia coli ST 131 Open

Gulraız Ahmad, Aqsa Khalid, Muhammad Usman Qamar, Nasır Rasool, Malik Saadullah , et al. · 2023

Development in the fields of natural-product-derived and synthetic small molecules is in stark contrast to the ongoing demand for novel antimicrobials to treat life-threatening infections caused by extended-spectrum β-lactamase producing E…

Epigenetic Targets and Pathways Linked to SARS-CoV-2 Infection and Pathology Open

Ali A. Rabaan, Mohammed Aljeldah, Basim R. Al Shammari, Roua A. Alsubki, Jawaher Alotaibi , et al. · 2023

The scale at which the SARS-CoV-2/COVID-19 pandemic has spread remains enormous. Provided the genetic makeup of the virus and humans is readily available, the quest for knowing the mechanism and epidemiology continues to prevail across the…

Pharmaceutical Treatment of Monkeypox Virus: A Narrative Review and Bibliometric Analysis Open

Muhammad Aaqib Shamim, Prakasini Satapathy, Bijaya Kumar Padhi, Sai Dutt Veeramachaneni, Naushaba Akhtar , et al. · 2022

Monkeypox virus infection is a recognized public health emergency. Little research has been done on treatment options for this disease. Until recently, there was not a single published work describing the usage of specific drugs in human p…

Tools to Alleviate the Drug Resistance in Mycobacterium tuberculosis Open

Ali A. Rabaan, Abbas Al Mutair, Hawra Albayat, Jawaher Alotaibi, Tarek Sulaiman , et al. · 2022

Mycobacterium tuberculosis (Mtb), an acid-fast bacillus that causes Tuberculosis (TB), is a pathogen that caused 1.5 million deaths in 2020. As per WHO estimates, another 4.1 million people are suffering from latent TB, either asymptomatic…

A Comparison between Vgg16 and Xception Models used as Encoders for Image Captioning Open

Asrar Almogbil, Amjad Alghamdi, Arwa Alsahli, Jawaher Alotaibi, Razan Alajlan , et al. · 2022

Image captioning is an intriguing topic in Natural Language Processing (NLP) and Computer Vision (CV). The present state of image captioning models allows it to be utilized for valuable tasks, but it demands a lot of computational power an…

The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section Open

Waleed Alhazzani, Mohammed Alshahrani, Fayez Alshamsi, Ohoud Aljuhani, Khalid Eljaaly , et al. · 2021

Alterations in the Plasma Proteome Induced by SARS-CoV-2 and MERS-CoV Reveal Biomarkers for Disease Outcomes for COVID-19 Patients Open

Ayodele Alaiya, Abeer N. Alshukairi, Zakia Shinwari, Mariam AL-Fares, Jawaher Alotaibi , et al. · 2021

We identified COVID-19 and MERS-CoV protein panels that have potential as biomarkers and might assist in the prognosis of SARS-CoV-2 infection. The identified markers further our understanding of COVID-19 disease pathophysiology and may ha…

SARS-CoV-2 Viral Load Is Correlated With the Disease Severity and Mortality in Patients With Cancer Open

Maha Al-Mozaini, Abu Shadat Mohammod Noman, Jawaher Alotaibi, Mohammad Rezaul Karim, ASM Zahed , et al. · 2021

The correlation between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viral load and risk of disease severity in cancer patients is poorly understood. Given the fact that cancer patients are at increased risk of severe coron…

The Saudi Critical Care Society Practice Guidelines on the Management of COVID-19 in the ICU: Therapy Section Open

Waleed Alhazzani, Mohammed Alshahrani, Fayez Alshamsi, Ohoud Aljuhani, Khalid Eljaaly , et al. · 2021

BackgroundThe rapid increase in coronavirus disease 2019 (COVID-19) cases during the subsequent waves in Saudi Arabia and other countries prompted the Saudi Critical Care Society (SCCS) to put together a panel of experts to issue evidence-…

SARS-CoV-2 viral load predicts the severity and mortality in patients with cancer Open

Maha Al-Mozaini, Abu Shadat Mohammod Noman, Jawaher Alotaibi, Mohammad Rezaul Karim, ASM Zahed , et al. · 2021

Emerging evidence suggests that patients with cancer are at increased risk of detrimental Covid-19 outcome. The relationship between SARS-CoV-2 viral load and risk factors and outcome of SARS-CoV-2 positive cancer patients remains largely …

A National Collaborative Multicenter Phase II Study for Potential Safety Efficacy of Convalescent Plasma to Treat Severe COVID-19 Patients Open

Hani Al Hashmi, Deia Alawami, Syed Ziauddin A. Zaidi, Nawal F Alshehry, Hazza Alzahrani , et al. · 2020

Introduction Coronavirus disease (COVID-19) pandemic has started to affect Saudi Arabia in the beginning of March 2020 and is expected to cause significant morbidity to many patients, especially to elderly, who might require intensive care…

Safety and Efficacy of Convalescent Plasma to Treat Severe COVID-19: Protocol for the Saudi Collaborative Multicenter Phase II Study Open

Mohammed Albalawi, Syed Ziauddin A. Zaidi, Nawal F Alshehry, Ahmed Alaskar, Abdul Rehman Zia Zaidi , et al. · 2020

Background The COVID-19 pandemic is expected to cause significant morbidity and mortality. The development of an effective vaccine will take several months to become available, and its affordability is unpredictable. Transfusion of convale…

Safety and Efficacy of Convalescent Plasma to Treat Severe COVID-19: Protocol for the Saudi Collaborative Multicenter Phase II Study (Preprint) Open

Mohammed Albalawi, Syed Ziauddin A. Zaidi, Nawal F Alshehry, Ahmed Alaskar, Abdul Rehman Zia Zaidi , et al. · 2020

BACKGROUND The COVID-19 pandemic is expected to cause significant morbidity and mortality. The development of an effective vaccine will take several months to become available, and its affordability is unpredictable. Transfusion of conval…

Cardiac implantable electronic device infection due to Mycobacterium species: a case report and review of the literature Open

Bandar Al‐Ghamdi, Hassan El Widaa, Maie Al Shahid, Mohammed Al‐Admawi, Jawaher Alotaibi , et al. · 2016

Cardiac implantable electronic devices infection due to Mycobacterium species is an uncommon but a well-known entity. Early diagnosis and prompt management may result in a better outcome.

Jawaher Alotaibi YOU? Author Swipe