Jay Chol Choi
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View article: Differential Effects of Admission Hemoglobin A <sub>1c</sub> by Estimated Glomerular Filtration Rate Stages on Mortality in Acute Ischemic Stroke and Diabetes
Differential Effects of Admission Hemoglobin A <sub>1c</sub> by Estimated Glomerular Filtration Rate Stages on Mortality in Acute Ischemic Stroke and Diabetes Open
Background The relationship between admission hemoglobin A 1c (HbA 1c ) levels, estimated glomerular filtration rate (eGFR) stages, and early outcomes may provide key insights into the need for individualized glycemic control based on kidn…
View article: Extending Dual Antiplatelet Therapy Beyond 3 Months in Acute Ischemic Stroke Due to Large‐Artery Atherosclerosis
Extending Dual Antiplatelet Therapy Beyond 3 Months in Acute Ischemic Stroke Due to Large‐Artery Atherosclerosis Open
Background The optimal duration of dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel following acute ischemic stroke due to large‐artery atherosclerosis remains uncertain. Methods We retrospectively analyzed data from a prospe…
View article: Supracardiac Atherosclerotic Lesions in Embolic Stroke of Undetermined Source: Predicting Stroke Recurrence and Enhancing Secondary Prevention Strategies
Supracardiac Atherosclerotic Lesions in Embolic Stroke of Undetermined Source: Predicting Stroke Recurrence and Enhancing Secondary Prevention Strategies Open
Background Identifying the potential cause of embolic stroke of undetermined source is essential for secondary prevention. We analyzed retrospectively collected real‐world data from the South Korean cohort with embolic stroke of undetermin…
View article: Temporal trends, outcomes, and predictors for endovascular thrombectomy in acute stroke patients with and without cancer
Temporal trends, outcomes, and predictors for endovascular thrombectomy in acute stroke patients with and without cancer Open
EVT is safe and effective for AIS patients with cancer, with similar reperfusion and complication rates as non-cancer patients. However, they often have worse outcomes. Laboratory markers can help personalize prognosis. Evolving treatment …
View article: Serum NOTCH3Extracellular Domain in Patients With CADASIL
Serum NOTCH3Extracellular Domain in Patients With CADASIL Open
These findings suggest that serum N3ECD alone has limited value as a standalone diagnostic marker for CADASIL. However, the age-dependent increase in N3ECD levels observed in specific variant carriers may reflect underlying pathophysiologi…
View article: A Practical Approach to Headache in Moyamoya Disease
A Practical Approach to Headache in Moyamoya Disease Open
Moyamoya disease (MMD) is a progressive steno-occlusive cerebrovascular disorder of the intracranial internal carotid arteries characterized by fragile collateral vessel formation. Although ischemic and hemorrhagic strokes are the most wid…
View article: Atrial Cardiopathy Worsens Neurological Severity, Raises Recurrence Rates, and Leads to Poor Vascular Outcomes in Patients With Embolic Stroke of Undetermined Source
Atrial Cardiopathy Worsens Neurological Severity, Raises Recurrence Rates, and Leads to Poor Vascular Outcomes in Patients With Embolic Stroke of Undetermined Source Open
Background and Purpose Atrial cardiopathy (AC) has been studied for its significance in embolic stroke of undetermined source (ESUS). This real-world study examines the relevance of AC in ESUS and its impact on stroke severity, recurrence,…
View article: Exploring the efficacy and safety of dual antiplatelet therapy in patients with embolic stroke of undetermined source according to stroke risk stratification: Propensity-score matched analysis
Exploring the efficacy and safety of dual antiplatelet therapy in patients with embolic stroke of undetermined source according to stroke risk stratification: Propensity-score matched analysis Open
DAPT did not confer benefit in unselected patients with ESUS but was effective in reducing END in high-risk individuals with ESRS ≥3. These findings support a risk-stratified approach to DAPT use in ESUS.
View article: Timing of Initiation and Efficacy of Dual Antiplatelet Therapy in Minor Stroke or High-Risk TIA
Timing of Initiation and Efficacy of Dual Antiplatelet Therapy in Minor Stroke or High-Risk TIA Open
Background Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is recommended within 24 hours for patients with minor ischemic stroke or high-risk transient ischemic attack (TIA). However, the optimal timing for initiating DAPT i…
View article: Temporal Patterns of Antithrombotic Therapy and Clinical Outcomes After Atrial Fibrillation-Related Stroke
Temporal Patterns of Antithrombotic Therapy and Clinical Outcomes After Atrial Fibrillation-Related Stroke Open
Background There is clinical equipoise in relation to the optimal timing and strategy for antithrombotic therapy in acute ischemic stroke (AIS) patients with atrial fibrillation (AF) who may be eligible for non-vitamin K antagonist oral an…
View article: Targeted temperature management in patients with acute basilar artery occlusion after successful recanalization
Targeted temperature management in patients with acute basilar artery occlusion after successful recanalization Open
Background and purpose Targeted temperature management (TTM) has been reported to improve outcomes in retrospective clinical studies, especially after recanalization in patients with anterior circulation stroke. However, the efficacy of TT…
View article: Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial
Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial Open
Introduction: This multicenter, double-blind, placebo-controlled trial, commissioned by South Korea’s Ministry of Food and Drug Safety, evaluated the effect of oxiracetam for preventing post-stroke cognitive impairment (PSCI) and explored …
View article: Abusive text transformation using LLMs
Abusive text transformation using LLMs Open
Although Large Language Models (LLMs) have demonstrated significant advancements in natural language processing tasks, their effectiveness in the classification and transformation of abusive text into non-abusive versions remains an area f…
View article: Sex Differences in the Clinical and Imaging Characteristics of Korean CADASIL Patients: A Korean Nationwide Retrospective Study
Sex Differences in the Clinical and Imaging Characteristics of Korean CADASIL Patients: A Korean Nationwide Retrospective Study Open
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease caused by NOTCH3 mutations. While CADASIL affects both sexes, differences in clinical pres…
View article: Persistent Beta‐Blocker Therapy Reduces Long‐Term Mortality in Patients With Acute Ischemic Stroke With Elevated Heart Rates
Persistent Beta‐Blocker Therapy Reduces Long‐Term Mortality in Patients With Acute Ischemic Stroke With Elevated Heart Rates Open
Background Elevated heart rate in patients with acute ischemic stroke is associated with increased risk of mortality. Beta‐blocker therapy is well known to reduce heart rate. Methods and Results This study was a post hoc analysis of patien…
View article: Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry
Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry Open
Background This study aims to evaluate temporal trends of advanced treatments and related clinical outcomes of ischemic stroke through a decade‐long trend analysis, using data from a comprehensive, national, multicenter registry. We also s…
View article: Comparative Effectiveness of Rosuvastatin Versus Atorvastatin in Acute Ischemic Stroke Treatment
Comparative Effectiveness of Rosuvastatin Versus Atorvastatin in Acute Ischemic Stroke Treatment Open
Background Research specifically addressing the efficacy of rosuvastatin versus atorvastatin in patients with ischemic stroke is insufficient. Using a large stroke registry, we investigated whether 2 commonly used statins, rosuvastatin and…
View article: Neurosonology education for undergraduate medical students in South Korea
Neurosonology education for undergraduate medical students in South Korea Open
This study assessed the status of neurosonology education for undergraduate medical students in South Korea. An online survey was conducted between September 1 and October 31, 2022, among neurology faculty members at 40 medical schools. Th…
View article: Long-Term Incidence of Gastrointestinal Bleeding Following Ischemic Stroke
Long-Term Incidence of Gastrointestinal Bleeding Following Ischemic Stroke Open
Background and Purpose Previous research on patients with acute ischemic stroke (AIS) has shown a 0.5% incidence of major gastrointestinal bleeding (GIB) requiring blood transfusion during hospitalization. The existing literature has insuf…
View article: Nelonemdaz and Patients With Acute Ischemic Stroke and Mechanical Reperfusion
Nelonemdaz and Patients With Acute Ischemic Stroke and Mechanical Reperfusion Open
Importance Nelonemdaz selectively antagonizes the 2B subunit of the N -methyl- d -aspartate glutamate receptor and scavenges free radical species. Objective To evaluate whether nelonemdaz enhances the clinical outcomes of patients with acu…
View article: Intracerebral hemorrhage in CADASIL
Intracerebral hemorrhage in CADASIL Open
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease caused by mutations in the NOTCH3 gene. This review highlights the increasing …
View article: Update of the Korean Clinical Practice Guidelines for Stroke: Blood Pressure Management
Update of the Korean Clinical Practice Guidelines for Stroke: Blood Pressure Management Open
Hypertension is a major risk factor for stroke, and appropriate management of blood pressure (BP) is crucial for both prevention and treatment. Since the 2009 publication of the Clinical Practice Guideline (CPG) by the Korean Stroke Societ…
View article: Tenecteplase in Acute Ischemic Stroke: A Scientific Statement From the Korean Stroke Society
Tenecteplase in Acute Ischemic Stroke: A Scientific Statement From the Korean Stroke Society Open
These statements are intended to support the adoption of TNK in countries where it is not yet available, including South Korea, by providing up-to-date clinical evidence. Their implementation may broaden the therapeutic options for AIS pat…