Jay E. Brock
YOU?
Author Swipe
View article: Design and Implementation of Improved SARS-CoV-2 Diagnostic Assays To Mitigate the Impact of Genomic Mutations on Target Failure: the Xpert Xpress SARS-CoV-2 Experience
Design and Implementation of Improved SARS-CoV-2 Diagnostic Assays To Mitigate the Impact of Genomic Mutations on Target Failure: the Xpert Xpress SARS-CoV-2 Experience Open
The SARS-CoV-2 genome has mutated during the coronavirus disease 2019 (COVID-19) pandemic. Some of these mutations have impacted the performance of nucleic acid amplification tests like PCR, which are commonly used as diagnostic tools to d…
View article: Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples Open
Background Clinical laboratories routinely use formalin-fixed paraffin-embedded (FFPE) tissue or cell block cytology samples in oncology panel sequencing to identify mutations that can predict patient response to targeted therapy. To under…
View article: A Model for Design and Implementation of a Laboratory Information-Management System Specific for Molecular Pathology Laboratory Operations
A Model for Design and Implementation of a Laboratory Information-Management System Specific for Molecular Pathology Laboratory Operations Open
The Molecular Pathology Section, Cleveland Clinic (Cleveland, OH), has undergone enhancement of its testing portfolio and processes. An Excel 2013- and paper-based data-management system was replaced with a commercially available laborator…
View article: Additional file 2 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Additional file 2 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples Open
Additional file 2. A multiple tab Microsoft Excel file of FFPE experiment information, extensive quality check data and analysis results for FFPE samples, and analysis results for free DNA samples.
View article: Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples Open
Additional file 3. List of known variants for four participating oncology panels.
View article: Endemic SARS-CoV-2 Polymorphisms Can Cause a Higher Diagnostic Target Failure Rate than Estimated by Aggregate Global Sequencing Data
Endemic SARS-CoV-2 Polymorphisms Can Cause a Higher Diagnostic Target Failure Rate than Estimated by Aggregate Global Sequencing Data Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to mutate during the ongoing COVID-19 pandemic, and some of the nucleotide polymorphisms may result in diagnostic detection failures. Documented polymorphisms resulting…
View article: Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples Open
Clinical laboratories routinely use formalin-fixed paraffin-embedded (FFPE) tissue or cell block cytology samples in oncology panel sequencing to identify mutations that can predict patient response to targeted therapy. To understand the t…
View article: A Comparison of Five SARS-CoV-2 Molecular Assays With Clinical Correlations
A Comparison of Five SARS-CoV-2 Molecular Assays With Clinical Correlations Open
Objectives Comparative assessments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) molecular assays that have been operationalized through the US Food and Drug Administration’s Emergency Use Authorization process are warran…
View article: Different prevalence and clinical outcome of Epstein-Barr virus positive diffuse large B-cell lymphoma between North American and non-Western populations
Different prevalence and clinical outcome of Epstein-Barr virus positive diffuse large B-cell lymphoma between North American and non-Western populations Open
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma among adults, presenting heterogeneous biological and clinical features. The 2008 World Health Organization (WHO) classification of Epstein-Barr virus po…