Jay Mandrekar
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View article: Performance of BIOFIRE FILMARRAY pneumonia panel in suspected pneumonia: insights from a real-world study
Performance of BIOFIRE FILMARRAY pneumonia panel in suspected pneumonia: insights from a real-world study Open
Pneumonia may be caused by a diverse group of microorganisms; however, a microbiologic diagnosis is not universally made. Molecular tests such as the BIOFIRE FILMARRAY Pneumonia Panel (BF-PP) offer the possibility of rapid identification o…
View article: Increased Risk of Myocardial Infarction in Inclusion Body Myositis: A Non‐Concurrent Cohort Study
Increased Risk of Myocardial Infarction in Inclusion Body Myositis: A Non‐Concurrent Cohort Study Open
Background Idiopathic inflammatory myopathies, beyond inclusion body myositis ( IBM ), have demonstrated an increased risk of adverse cardiovascular outcomes, particularly myocardial infarction ( MI ). This study evaluated the risk of card…
View article: Assessing fall risk in multiple sclerosis using patient-reported outcomes and wearable gait metrics
Assessing fall risk in multiple sclerosis using patient-reported outcomes and wearable gait metrics Open
Background Falls in people with multiple sclerosis (pwMS) lead to morbidity and expense. Objective Identify clinical metrics associated with falls. Methods Eighty-six pwMS completed fall surveys, timed 25-foot walk (T25FW), and motion anal…
View article: A systematic review and meta-analysis of the response to placebo in clinical trials of inclusion body myositis
A systematic review and meta-analysis of the response to placebo in clinical trials of inclusion body myositis Open
Objectives IBM is characterized by slowly progressive muscle weakness making it challenging to detect significant changes in weakness during a clinical trial. Trial participants receiving placebo may behave differently from in natural hist…
View article: P-1498. Contezolid is Active against Methicillin-Resistant <i>Staphylococcus aureus</i> in Experimental Rat Foreign Body Osteomyelitis
P-1498. Contezolid is Active against Methicillin-Resistant <i>Staphylococcus aureus</i> in Experimental Rat Foreign Body Osteomyelitis Open
Background Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of orthopedic implant-associated infection, where S. aureus can survive intracellularly and form biofilms. Vancomycin has poor activity against staphyloccoccal…
View article: Assessing Family Caregiver Readiness for Hospital Discharge of Patients With Serious or Life‐Limiting Illness Using Electronic Health Record and Self‐Reported Data
Assessing Family Caregiver Readiness for Hospital Discharge of Patients With Serious or Life‐Limiting Illness Using Electronic Health Record and Self‐Reported Data Open
Objective To assess how patient and caregiver factors influence caregiver readiness for hospital discharge in palliative care patients. Study Setting and Design This transitional care study uses cross‐sectional data from a randomized contr…
View article: MOG antibody-associated disease epidemiology in Olmsted County, USA, and Martinique
MOG antibody-associated disease epidemiology in Olmsted County, USA, and Martinique Open
View article: Beyond grief: Quantifying bereavement needs of rural family caregivers
Beyond grief: Quantifying bereavement needs of rural family caregivers Open
Objectives Family caregivers (FCGs) may experience numerous psychosocial and practical challenges with interpersonal relationships, mental health, and finances both before and after their care recipient (CR) dies. The specific challenges a…
View article: Resilient living program for patients with advanced cancer and their caregivers
Resilient living program for patients with advanced cancer and their caregivers Open
Objectives Patients with advanced cancer and their caregivers experience a substantial amount of anxiety and distress. The purpose of this study was to assess the feasibility, acceptability, and preliminary effects of an 8-week, remotely d…
View article: NLRP3 Inflammasome Activation and Altered Mitophagy Are Key Pathways in Inclusion Body Myositis
NLRP3 Inflammasome Activation and Altered Mitophagy Are Key Pathways in Inclusion Body Myositis Open
Background Inclusion body myositis (IBM) is the most prevalent muscle disease in adults for which no current treatment exists. The pathogenesis of IBM remains poorly defined. In this study, we aimed to explore the interplay between inflamm…
View article: HEALTH CARE USE AND OUT-OF-POCKET COSTS FOR RURAL FAMILY CAREGIVERS AND CARE RECIPIENTS IN TRANSITIONAL PALLIATIVE CARE
HEALTH CARE USE AND OUT-OF-POCKET COSTS FOR RURAL FAMILY CAREGIVERS AND CARE RECIPIENTS IN TRANSITIONAL PALLIATIVE CARE Open
Few studies have reliable estimates on costs of informal care following hospitalization, including health care use and out-of-pocket costs for family caregivers (FCGs) and their care recipients (CR). This presentation discusses results fro…
View article: RECRUITING FAMILY CAREGIVERS FOR INTERVENTIONS DESIGNED TO OPTIMIZE TRANSITIONS FROM HOSPITAL TO HOME
RECRUITING FAMILY CAREGIVERS FOR INTERVENTIONS DESIGNED TO OPTIMIZE TRANSITIONS FROM HOSPITAL TO HOME Open
Recruiting family caregivers to participate in research, especially caregivers of people with severe or life limiting illnesses transitioning from hospital to home, is challenging. Traditional approaches for recruitment, including recruitm…
View article: A TECHNOLOGY-BASED TRANSITIONAL PALLIATIVE CARE INTERVENTION FOR FAMILY CAREGIVERS IN RURAL OR UNDERSERVED AREAS
A TECHNOLOGY-BASED TRANSITIONAL PALLIATIVE CARE INTERVENTION FOR FAMILY CAREGIVERS IN RURAL OR UNDERSERVED AREAS Open
In this presentation, Dr. Griffin will describe the Technology-Enhanced Transitional Palliative Care (TPC) study, a randomized controlled trial testing the efficacy and cost-effectiveness of an intervention to address FCGs’ unmet needs in …
View article: CONNECTIVITY ISSUES WHEN CONDUCTING A VIRTUAL CLINICAL TRIAL WITH FAMILY CAREGIVERS IN RURAL OR UNDERSERVED AREAS
CONNECTIVITY ISSUES WHEN CONDUCTING A VIRTUAL CLINICAL TRIAL WITH FAMILY CAREGIVERS IN RURAL OR UNDERSERVED AREAS Open
In the research literature and amongst grant reviewers, there are persistent questions about whether internet connectivity challenges, especially in rural populations, will limit the potential for virtual or decentralized clinical trials t…
View article: Pleural space infection microbiology as assessed using a clinical sequencing-based assay: <i>Fusobacterium nucleatum</i> group, <i>Streptococcus intermedius,</i> and other oral normal microbiota are the most common bacteria identified in community-acquired pleural space infections
Pleural space infection microbiology as assessed using a clinical sequencing-based assay: <i>Fusobacterium nucleatum</i> group, <i>Streptococcus intermedius,</i> and other oral normal microbiota are the most common bacteria identified in community-acquired pleural space infections Open
The definition of the microbiology of pleural space infection has been challenging due to the poor yield of conventional culture. Here, the results of a 16S ribosomal RNA gene PCR/sequencing assay performed on pleural fluid in routine clin…
View article: Rapid multiplex PCR panel for pneumonia in hospitalised patients with suspected pneumonia in the USA: a single-centre, open-label, pragmatic, randomised controlled trial
Rapid multiplex PCR panel for pneumonia in hospitalised patients with suspected pneumonia in the USA: a single-centre, open-label, pragmatic, randomised controlled trial Open
bioMérieux.
View article: The impact of internet connectivity when conducting a virtual clinical trial with participants living in rural areas
The impact of internet connectivity when conducting a virtual clinical trial with participants living in rural areas Open
View article: Accelerated Resolution Therapy for Early Maladaptive Grief Study Protocol
Accelerated Resolution Therapy for Early Maladaptive Grief Study Protocol Open
The objective of this manuscript is to present the protocol of a study aiming to test the effects of Accelerated Resolution Therapy® (ART) on pre-loss grief and prolonged grief among older adult family caregivers. This study also aims to b…
View article: A comparison of phage susceptibility testing with two liquid high-throughput methods
A comparison of phage susceptibility testing with two liquid high-throughput methods Open
Phage therapy is a promising antibacterial strategy, especially given that drug-resistant bacterial infections are escalating worldwide. Because phages are not active against all strains of a given species, phages being considered for ther…
View article: Caregiver recruitment strategies for interventions designed to optimize transitions from hospital to home: lessons from a randomized trial
Caregiver recruitment strategies for interventions designed to optimize transitions from hospital to home: lessons from a randomized trial Open
View article: NLRP3 inflammasome activation and altered mitophagy are key pathways in inclusion body myositis
NLRP3 inflammasome activation and altered mitophagy are key pathways in inclusion body myositis Open
Background Inclusion body myositis (IBM) is the most prevalent muscle disease in adults for which no current treatment exists. The pathogenesis of IBM remains poorly defined. Inflammation and mitochondrial dysfunction are the most common h…
View article: Individualized Cell-Free DNA Monitoring With Chromosomal Junctions for Mesothelioma
Individualized Cell-Free DNA Monitoring With Chromosomal Junctions for Mesothelioma Open
With further validation, individualized ctDNA junction assays could supplement imaging for disease monitoring in mesothelioma.
View article: MR Imaging Features of Critical Spinal Demyelinating Lesions Associated with Progressive Motor Impairment
MR Imaging Features of Critical Spinal Demyelinating Lesions Associated with Progressive Motor Impairment Open
Focal, lesion-associated atrophy, lateral column axial location, and larger lesion size are spinal cord MR imaging characteristics of critical demyelinating lesions. The presence of critical demyelinating lesions should be sought as these …
View article: Phage K exposure generates phage-neutralizing activity in a rabbit model—humoral receptiveness may impact efficacy of phage therapy
Phage K exposure generates phage-neutralizing activity in a rabbit model—humoral receptiveness may impact efficacy of phage therapy Open
Phage therapy has not been established in the clinical routine, in part due to uncertainties concerning efficacy and immunogenicity. Here, three rabbits were immunized against staphylococcal phage K to assess viral potency in the presence …
View article: Evaluation of Sonicate Fluid Culture Cutoff Points for Periprosthetic Joint Infection Diagnosis
Evaluation of Sonicate Fluid Culture Cutoff Points for Periprosthetic Joint Infection Diagnosis Open
Introduction Implant sonication is useful for recovery of periprosthetic joint infection (PJI) pathogens in culture, but exact cutoff points for definition of clinically significant sonicate fluid culture results vary from study to study. …
View article: The Impact of Internet Connectivity When Conducting a Virtual Clinical Trial with Participants Living in Rural or Medically Underserved Areas
The Impact of Internet Connectivity When Conducting a Virtual Clinical Trial with Participants Living in Rural or Medically Underserved Areas Open
View article: Mitochondrial myopathies diagnosed in adulthood: clinico-genetic spectrum and long-term outcomes
Mitochondrial myopathies diagnosed in adulthood: clinico-genetic spectrum and long-term outcomes Open
Mitochondrial myopathies are frequently recognized in childhood as part of a broader multisystem disorder and often overlooked in adulthood. Herein, we describe the phenotypic and genotypic spectrum and long-term outcomes of mitochondrial …
View article: Women Have a Lower Rate of Abdominal Aortic Aneurysm Repair and Higher Long-Term Aortic Mortality Compared to Men in a Population Based Study Spanning 4 Decades
Women Have a Lower Rate of Abdominal Aortic Aneurysm Repair and Higher Long-Term Aortic Mortality Compared to Men in a Population Based Study Spanning 4 Decades Open
View article: Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome
Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome Open
BACKGROUND: Cerebral cavernous malformation with symptomatic hemorrhage (SH) are targets for novel therapies. A multisite trial-readiness project ( https://www.clinicaltrials.gov ; Unique identifier: NCT03652181) aimed to identify clinical…
View article: The clinical spectrum of MELAS and associated disorders across ages: a retrospective cohort study
The clinical spectrum of MELAS and associated disorders across ages: a retrospective cohort study Open
Objective Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a severe multisystemic disease, although some have a milder phenotype. We aimed to evaluate the clinical spectrum of this disease from MELAS pa…