Jay A. Nelson
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Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice Open
Human cytomegalovirus (HCMV) actively manipulates cellular signaling pathways to benefit viral replication. Phosphatidyl-inositol 3-kinase (PI3K)/Akt signaling is an important negative regulator of HCMV replication, and during lytic infect…
Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34 <sup>+</sup> hematopoietic progenitor cells and humanized mice Open
Human cytomegalovirus (HCMV) actively manipulates cellular signaling pathways to benefit viral replication. Phosphatidyl-inositol 3-kinase (PI3K)/Akt signaling is an important negative regulator of HCMV replication, and during lytic infect…
Prophylactic treatment with PEGylated bovine IFNλ3 effectively bridges the gap in vaccine-induced immunity against FMD in cattle Open
Foot-and-mouth disease (FMD) is a vesicular disease of cloven-hoofed animals with devastating economic implications. The current FMD vaccine, routinely used in enzootic countries, requires at least 7 days to induce protection. However, FMD…
Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection Open
Innate immune responses are crucial for limiting virus infection. However, viruses often hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta herpesvirus which establishes a life-long latent infection. Defi…
Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infection Open
Innate immune responses are crucial for limiting virus infection. However, viruses often hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta herpesvirus which establishes a life-long latent infection. Defi…
View article: Virology under the Microscope—a Call for Rational Discourse
Virology under the Microscope—a Call for Rational Discourse Open
Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines …
View article: Virology under the Microscope—a Call for Rational Discourse
Virology under the Microscope—a Call for Rational Discourse Open
Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines …
View article: Virology under the Microscope—a Call for Rational Discourse
Virology under the Microscope—a Call for Rational Discourse Open
Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines …
View article: Myeloid cell tropism enables MHC-E–restricted CD8 <sup>+</sup> T cell priming and vaccine efficacy by the RhCMV/SIV vaccine
Myeloid cell tropism enables MHC-E–restricted CD8 <sup>+</sup> T cell priming and vaccine efficacy by the RhCMV/SIV vaccine Open
The strain 68-1 rhesus cytomegalovirus (RhCMV)–based vaccine for simian immunodeficiency virus (SIV) can stringently protect rhesus macaques (RMs) from SIV challenge by arresting viral replication early in primary infection. This vaccine e…
Human Cytomegalovirus miR-US25-1 Targets the GTPase RhoA To Inhibit CD34 <sup>+</sup> Hematopoietic Progenitor Cell Proliferation To Maintain the Latent Viral Genome Open
Each herpesvirus family establishes latency in a unique cell type. Since herpesviruses genomes are maintained as episomes, the viruses need to devise mechanisms to retain the latent genome during cell division.
View article: Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy
Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy Open
Eight RhCMV gene products control induction of unconventionally restricted CD8 + T cells and RhCMV/SIV vaccine efficacy.
View article: Granulocyte-Colony Stimulating Factor Reactivates Human Cytomegalovirus in a Latently Infected Humanized Mouse Model
Granulocyte-Colony Stimulating Factor Reactivates Human Cytomegalovirus in a Latently Infected Humanized Mouse Model Open
Human cytomegalovirus (HCMV) continues to be a significant cause of morbidity and mortality in organ transplant recipients despite the availability of antiviral therapy. Considerable controversy exists regarding the use of granulocyte-colo…
View article: Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy
Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy Open
Simian immunodeficiency virus (SIV) insert-expressing, 68-1 Rhesus Cytomegalovirus (RhCMV/SIV) vectors elicit major histocompatibility complex (MHC)-E- and -II-restricted, SIV-specific CD8 + T cell responses, but the basis of these unconve…
Human Cytomegalovirus Infection Suppresses CD34+ Progenitor Cell Engraftment in Humanized Mice Open
Human cytomegalovirus (HCMV) infection is a serious complication in hematopoietic stem cell transplant (HSCT) recipients due to virus-induced myelosuppression and impairment of stem cell engraftment. Despite the clear clinical link between…
Human Cytomegalovirus Infection Suppresses CD34+ Progenitor Cell Engraftment in Humanized Mice Open
Human Cytomegalovirus (HCMV) infection is a serious complication in hematopoietic stem cell transplant (HSCT) recipients due to virus-induced myelosuppression and impairment of stem cell engraftment. Despite the clear clinical link between…
Hypoxia tolerance is unrelated to swimming metabolism of wild, juvenile striped bass (<i>Morone saxatilis</i>) Open
Juvenile striped bass reside in the Chesapeake Bay where they are likely to encounter hypoxia that could affect their metabolism and performance. The ecological success of this economically valuable species may depend on their ability to t…
Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency Open
Sustained phosphotinositide3-kinase (PI3K) signaling is critical to the maintenance of alpha and beta herpesvirus latency. We have previously shown that the beta-herpesvirus, human cytomegalovirus (CMV), regulates epidermal growth factor r…
Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34 <sup>+</sup> Hematopoietic Progenitor Cells and Humanized NSG Mice Open
Human cytomegalovirus (HCMV) can establish latency following infection of CD34 + hematopoietic progenitor cells (HPCs), and reactivation from latency is a significant cause of viral disease and accelerated graft failure in bone marrow and …
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology Open
Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital Zika Syndrome (CZS). Here we infec…
Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues Open
[This corrects the article DOI: 10.1371/journal.ppat.1006219.].
Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues Open
Zika virus (ZIKV), an emerging flavivirus, has recently spread explosively through the Western hemisphere. In addition to symptoms including fever, rash, arthralgia, and conjunctivitis, ZIKV infection of pregnant women can cause microcepha…
Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques Open
Cytomegaloviruses (CMV) are highly species-specific due to millennia of co-evolution and adaptation to their host, with no successful experimental cross-species infection in primates reported to date. Accordingly, full genome phylogenetic …
Complex Interplay of the <i>UL136</i> Isoforms Balances Cytomegalovirus Replication and Latency Open
Human cytomegalovirus (HCMV), a betaherpesvirus, persists indefinitely in the human host through poorly understood mechanisms. The UL136 gene is carried within a genetic locus important to HCMV latency termed the UL133 / 8 locus, which als…
View article: Broadly targeted CD8 <sup>+</sup> T cell responses restricted by major histocompatibility complex E
Broadly targeted CD8 <sup>+</sup> T cell responses restricted by major histocompatibility complex E Open
An unconventional route to protection One promising approach toward an HIV-1 vaccine involves infecting people with cytomegalovirus engineered to express proteins from HIV-1. This approach, which works by eliciting virus-killing CD8 + T ce…
Oxygen consumption rate <i>v.</i> rate of energy utilization of fishes: a comparison and brief history of the two measurements Open
Accounting for energy use by fishes has been taking place for over 200 years. The original, and continuing gold standard for measuring energy use in terrestrial animals, is to account for the waste heat produced by all reactions of metabol…