Explanipedia

Cemento-Ossifying Fibroma of the Craniofacial Region: A Diagnostically Challenging Case Report Open

Jay Patel, Samir Joshi, Sudhir Pawar, Vivek Nair, Vaishali Koranne · 2025

Cellular fibrous connective tissue, which eventually mineralizes, replaces normal bone in a class of illnesses known as benign fibro-osseous lesions. Fibrous dysplasia, ossifying fibroma, and osseous dysplasia are the three most common for…

Cutis Laxa Associated with a Missense Variant in ELN gene Open

Jay Patel, Vedha Vaddaraju, Jennifer Dykeman, Eran Tallis, Kathleen Mannava , et al. · 2025

Fiscal Levy to Combat Sweetened Beverages Consumption: A Global Regulatory Approach Open

Anmol Mathur, Aditi Mathur, Jay Patel, Miral Mehta, Hiren Hansraj Patadiya · 2025

Sugar consumption has increased considerably in recent times. Its consumption has been considered an addiction and has gained attention by global healthcare agencies. Sugar consumption has serious health effects and is being documented as …

Osteogenic Small Molecule FK506 for Enhanced Bone Formation in a Rabbit Ankle Fusion Model Open

Nicholas Huffman, A. Magesh, Hanna Solomon, Caroline Dingler, Sreedhara Sangadala , et al. · 2025

Non‐union remains a significant complication following ankle fusion procedures, underscoring the need for effective osteogenic adjuvants to improve boney healing and fusion outcomes. This study investigates the osteogenic potential of FK50…

Diverse Lenabasum pathway activation in dermatomyositis patients’ blood Open

Nilesh Kodali, DeAnna Diaz, Rohan Dhiman, Thomas Vazquez, Rui Feng , et al. · 2025

Lenabasum, a non-psychoactive cannabinoid type-2 receptor (CB2R) agonist, has shown promise in reducing cutaneous disease in Dermatomyositis (DM) patients. Lenabasum activates two distinct receptors: CB2R and the nuclear peroxisome prolife…

Comparative Evaluation of Bioactive Glass Microspheres versus Chlorhexidine Chips in the Treatment of Chronic Periodontitis: A Randomized Controlled Clinical Trial Open

Anuj Singh Parihar, Jay Patel, Hiren H Patadiya, Kanchanahalli Siddegowda Sadananda, Pradeep Adatrow , et al. · 2025

A BSTRACT Background: Chronic periodontitis is a prevalent inflammatory disease characterized by the progressive destruction of the tooth-supporting apparatus. This randomized controlled clinical trial investigated the comparative efficacy…

Microneedling Technique With Topical Vitamin C for Gingival Depigmentation Enhancing Gingival Aesthetics: A Longitudinal Study Open

Sepideh Mansuri, Tanvi Hirani, Jay Patel, Shirishkumar Patel, Dipak Chaudhari , et al. · 2025

Introduction As the focus on dental aesthetics intensifies, contemporary cosmetic dentistry seeks to establish an equilibrium between teeth and gums. Gingival hyperpigmentation, resulting from excessive melanin accumulation, can impact ind…

Generating New Meniscus Therapies via Recent Breakthroughs in Development, Model Systems, and Clinical Diagnostics Open

Rebecca M. Irwin, Matthew Brown, Matthew F. Koff, Chang H. Lee, Elisabeth A. Lemmon , et al. · 2025

Over 850,000 surgeries are performed to treat meniscal injuries each year in the United States. Even with repair, patients are likely to develop osteoarthritis (OA) within the next two decades. There is a pressing clinical need to improve …

The Interplay Between Early Chondrocyte Spreading and Inflammatory Responsivity Open

Tristan Pepper, Saitheja A. Pucha, Lauren Foster, Alan Y. Liu, Mary Jane Alexander , et al. · 2025

Joint injuries are increasingly common and initiate a degenerative cascade in the cartilage extracellular matrix. Chondrocytes experience both intra‐ and extra‐cellular changes during the initial phases of this process, including inflammat…

Experimental investigation of thermal characteristics of a 12S1P Li-ion NMC-21700 battery module under different environments for EV applications Open

Jay Patel, Rajesh Patel, Rajat Saxena, Abhishek Nair · 2025

The rapid growth of electric vehicles (EVs) has placed significant emphasis on the performance and safety of lithium-ion (Li-ion) batteries, which serve as the primary energy storage solution. Effective thermal management is crucial to ens…

The evaluation of platelet lysate incorporation into the microfracture clot in a pig model Open

Hanna Solomon, Julie Gordon, Maddie Hasson, Hannah Arnade, Jordan Parker , et al. · 2025

Schematic illustration of platelet lysate incorporation, evaluated both within in vitro fibrin gels and in vivo microfracture clots.

Performance Evaluation of Monochromatic and Combined Uvgi Wavelengths for Airborne E. Coli Inactivation in an Hvac Duct Open

Jay Patel, Kathleen K. M. Glover, Lexuan Zhong · 2025

An analysis of drug approvals in India over past 5 years Open

A Shaikh, Chetankumar R. Acharya, Ajul Shah, Manan G. Moradiya, Jay Patel , et al. · 2024

Background: Drug development is a tedious process and takes a long time for approval by regulatory authorities. With time, Indian authorities have revised rules and regulations for conducting clinical trials as well as for the marketing of…

Platelet-Derived Growth Factor has Context-Dependent Effects on Osteogenesis in Bone Marrow-Derived Cells Open

Nicholas Huffman, Jacqueline Gillis, A. Magesh, Sreedhara Sangadala, Jay Patel , et al. · 2024

Category: Basic Sciences/Biologics; Ankle Arthritis Introduction/Purpose: Arthrodesis stands as the primary method for treating advanced osteoarthritis in the foot and ankle [1]. However, a significant hurdle in this procedure is non-union…

Enhancing Thermal Performance and Cooling Solutions of Phase Change Material in Battery Thermal Management System: A Computational Analysis Open

Gourav Kumar Singh, Jay Patel, Manish K. Rathod · 2024

Batteries, particularly lithium‐ion batteries, are sensitive to temperature changes. Battery thermal management systems (BTMS) are essential in various battery‐powered applications, especially electric vehicles (EVs) and portable electroni…

Effect of Organic Manures on Productivity of Greengram-wheat Cropping Sequence under Organic Farming Open

Jay Patel, Manisha Chaudhary, D. M. Patel, J. C. Patel, JA Patel , et al. · 2024

Manures are significant organic source of plant nutrients. Farmer’s awareness is increasing towards organic farming. An experiment was conducted during kharif and Rabi season of the years 2016-17 to 2018-19 (Three years) at Agronomy Instru…

Effect of Organic Manures on Productivity in a Groundnut-Wheat Sequence under Organic Farming Open

Jay Patel, Manisha Chaudhary, D. M. Patel, J. C. Patel · 2024

An experiment was conducted during two consecutivekharif and rabi season from the year 2016-17 to 2018-19 for three years on to evaluate different organic sources performance on groundnut and wheat sequence under organic farming at Agronom…

Nitrogen Management in Kharif Pearlmillet Open

Jay Patel, D. M. Patel, Jitesh Desai · 2024

An experiment was conducted during kharifseason of the years 2021 to 2023 (Three years) at Agronomy Instructional Farm, Chimanbhai Patel College of Agriculture, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar having …

Considering the Cellular Landscape in Marrow Stimulation Techniques for Cartilage Repair Open

Maddie Hasson, Lorenzo M. Fernandes, Hanna Solomon, Tristan Pepper, Nicholas Huffman , et al. · 2024

Background: Marrow stimulation is a common reparative approach to treat injuries to cartilage and other soft tissues (e.g., rotator cuff). It involves the recruitment of bone marrow elements and mesenchymal stem cells (MSCs) …

Single-Cell RNA Sequencing Reveals Dysregulated POSTN+WNT5A+ Fibroblast Subclusters in Prurigo Nodularis Open

Jay Patel, Marina Z. Joel, Kevin K. Lee, Anusha Kambala, Hannah Cornman , et al. · 2024

Prurigo nodularis (PN) is an intensely pruritic, inflammatory skin disease with a poorly understood pathogenesis. We performed single-cell transcriptomic profiling of 28,695 lesional and nonlesional PN cells. Lesional PN has increased dysr…

Revealing Early Spatial Patterns of Cellular Responsivity in Fiber-Reinforced Microenvironments Open

Saitheja A. Pucha, Maddie Hasson, Hanna Solomon, Gail E. McColgan, Jennifer L. Robinson , et al. · 2024

Fiber-reinforcement approaches have been utilized to replace aligned tissues with engineered constructs after injury or surgical resection, strengthening soft biomaterial scaffolds and replicating anisotropic, load-bearing properties. Howe…

Yield Maximization of Bt Cotton Through Agro-techniques Open

V. B. Gohil, D. M. Patel, Mohit Chaudhary, N. B. Gohil, Jay Patel · 2023

A field experiment was conducted during the two consecutive kharif seasons of 2019 and 2020 at Agronomy Instructional Farm, Chimanbhai Patel College of Agriculture, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, to…

Plasmacytoid Dendritic Cells Are Not Major Producers of Type 1 IFN in Cutaneous Lupus: An In-Depth Immunoprofile of Subacute and Discoid Lupus Open

Thomas Vazquez, Jay Patel, Nilesh Kodali, DeAnna Diaz, Muhammad M. Bashir , et al. · 2023

Herbal supplement Spirulina stimulates inflammatory cytokine production in patients with dermatomyositis in vitro Open

Christina E. Bax, DeAnna Diaz, Yubin Li, Thomas Vazquez, Jay Patel , et al. · 2023

Combinatorial Small Molecule Enhancement of Osteogenesis for Ankle Arthrodesis Open

Nicholas Huffman, Bereket Getachew, Jason T. Bariteau, Jay Patel, Sreedhara Sangadala · 2023

Category: Basic Sciences/Biologics; Ankle Introduction/Purpose: One of the most common procedures for treating end-stage osteoarthritis of the foot and ankle is arthrodesis [1]. However, a significant complication with arthrodesis is the d…

Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel Open

Riley Brackin, Gail E. McColgan, Saitheja A. Pucha, Michael A. Kowalski, Hicham Drissi , et al. · 2023

Traumatic joint injuries are common, leading to progressive tissue degeneration and the development of osteoarthritis. The post-traumatic joint experiences a pro-inflammatory milieu, initiating a subtle but deteriorative process in cartila…

Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularis Open

Shawn G. Kwatra, Jay Patel, Marina Z. Joel, Kevin K. Lee, Anusha Kambala , et al. · 2023

Background: Prurigo nodularis (PN) is an intensely pruritic, inflammatory skin disease with a poorly understood pathogenesis. Methods: We performed single-cell transcriptomic profiling of 28,695 lesional and non-lesional PN cells. Results:…

Exogenous All-<i>Trans</i>Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice Open

Dillon M. Brown, Jianshi Yu, Praveen Kumar, Quinn M. Paulus, Michael A. Kowalski , et al. · 2023

In mice, atRA treatment results in an axial myopia phenotype. Eyes developed myopic RE and larger VCD without the anterior eye being affected. The decrease in stiffness and increase in permeability of the sclera are consistent with the for…

Obstructed hemivagina with ipsilateral renal agenesis (OHVIRA) syndrome: Typical presentation of a rare syndrome Open

Bhavana Devanabanda, Bradley Chatterton, Irfan Nazir Hassan, Jay Patel · 2023

A comparison of the efficacy of Skindex-16 and Skindex-29 in dermatomyositis Open

Joshua Dan, Grant Sprow, Josef Concha, Jay Patel, Nilesh Kodali , et al. · 2023

Recently, more emphasis has been placed on patient-reported outcomes in clinical trials, which has inadvertently led to an increase in respondent burden. In this study, we found that the Skindex-16 form captures patient-reported quality of…

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