Jay Saoud
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View article: Efficacy and Safety of Seltorexant in Insomnia Disorder
Efficacy and Safety of Seltorexant in Insomnia Disorder Open
Importance Existing pharmacological treatments for insomnia have significant limitations. Objective To assess the effective dose range, safety, and tolerability of the novel selective orexin-2 receptor antagonist seltorexant in insomnia di…
View article: Somno-Art Software identifies pathology-induced changes in sleep parameters similarly to polysomnography
Somno-Art Software identifies pathology-induced changes in sleep parameters similarly to polysomnography Open
Polysomnographic sleep architecture parameters are commonly used to diagnose or evaluate treatment of sleep disorders. Polysomnography (PSG) having practical constraints, the development of wearable devices and algorithms to monitor and st…
View article: 0951 Inter-Scorer Reliability between Somno-Art Software and 5 Sleep Centers
0951 Inter-Scorer Reliability between Somno-Art Software and 5 Sleep Centers Open
Introduction A number of studies have evaluated epoch-by-epoch agreement between 2 technologists in scoring individual sleep stage. Scoring for the specific sleep stages average agreement ranged from 20% to 90% in different studies. The go…
View article: Long-term effects of Roluperidone on negative symptoms of schizophrenia
Long-term effects of Roluperidone on negative symptoms of schizophrenia Open
Roluperidone has antagonist properties for 5-HT2A, sigma2, α1A- and α1B-adrenergic receptors, but no dopaminergic binding affinities. In 2 randomized controlled trials (RCT), treatment improved negative symptoms of schizophrenia and social…
View article: Performance of Somno-Art Software compared to polysomnography interscorer variability: A multi-center study
Performance of Somno-Art Software compared to polysomnography interscorer variability: A multi-center study Open
The visual scoring of gold standard polysomnography (PSG) is known to present inter- and intra-scorer variability. Previously, Somno-Art Software, a cardiac based sleep scoring algorithm, has been validated in comparison to 2 expert visual…
View article: Efficacy and Safety of Roluperidone for the Treatment of Negative Symptoms of Schizophrenia
Efficacy and Safety of Roluperidone for the Treatment of Negative Symptoms of Schizophrenia Open
Background This is a placebo-controlled multi-national trial of roluperidone, a compound with antagonist properties for 5-HT2A, sigma2, and α1A-adrenergic receptors, targeting negative symptoms in patients with schizophrenia. This trial fo…
View article: Validation of Somno-Art Software, a novel approach of sleep staging, compared with polysomnography in disturbed sleep profiles
Validation of Somno-Art Software, a novel approach of sleep staging, compared with polysomnography in disturbed sleep profiles Open
Study Objectives Integrated analysis of heart rate (electrocardiogram [ECG]) and body movements (actimetry) during sleep in healthy subjects have previously been shown to generate similar evaluation of sleep architecture and continuity wit…
View article: 0504 Efficacy and Safety of Seltorexant in Insomnia Disorder
0504 Efficacy and Safety of Seltorexant in Insomnia Disorder Open
Introduction Insomnia disorder affects 3-6% of the population and includes functional impairing symptoms for ≥3 months. Current hypnotics have limitations (eg fall risk, dependency, parasomnia, cognitive impairment). In a previous proof-of…
View article: Depression in Heart Failure: A Systematic Review.
Depression in Heart Failure: A Systematic Review. Open
Objective: This paper sought to identify the instruments used to measure depression in heart failure (HF) and elucidate the impact of treatment interventions on depression in HF. Methods: The Preferred Reporting Items for Systematic Review…
View article: Network Analysis Indicates That Avolition Is the Most Central Domain for the Successful Treatment of Negative Symptoms: Evidence From the Roluperidone Randomized Clinical Trial
Network Analysis Indicates That Avolition Is the Most Central Domain for the Successful Treatment of Negative Symptoms: Evidence From the Roluperidone Randomized Clinical Trial Open
A recent conceptual development in schizophrenia is to view its manifestations as interactive networks rather than individual symptoms. Negative symptoms, which are associated with poor functional outcome and reduced rates of recovery, rep…
View article: Cognitive Effects of MIN-101 in Patients With Schizophrenia and Negative Symptoms
Cognitive Effects of MIN-101 in Patients With Schizophrenia and Negative Symptoms Open
EU Clinical Trials Register identifier: 2014-004878-42.
View article: Efficacy and Safety of MIN-101: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of a New Drug in Development for the Treatment of Negative Symptoms in Schizophrenia
Efficacy and Safety of MIN-101: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of a New Drug in Development for the Treatment of Negative Symptoms in Schizophrenia Open
MIN-101 demonstrated statistically significant efficacy in reducing negative symptoms and good tolerability in stable schizophrenia patients.
View article: Assessing sleep architecture and continuity measures through the analysis of heart rate and wrist movement recordings in healthy subjects: comparison with results based on polysomnography
Assessing sleep architecture and continuity measures through the analysis of heart rate and wrist movement recordings in healthy subjects: comparison with results based on polysomnography Open
The automatic analysis of heart rate and body movement during sleep allows for the evaluation of sleep architecture and continuity that is equivalent to those obtained by manual scoring of polysomnography. The technique used here is simple…