Jay Schulkin
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View article: The Fast and the Curious: Creative Improvisation as Action-oriented Abduction
The Fast and the Curious: Creative Improvisation as Action-oriented Abduction Open
Improvisation, understood as a skillful activity, suggests a tension between the constitutive roles of habit and creativity. Cognitive and phenomenological accounts of skill acquisition point to the importance of developing habitual respon…
View article: Creative Resilience
Creative Resilience Open
We articulate a conception of resilience via allostasis and the free energy principle to augment Nassim Nicholas Taleb’s conception of antifragility. Creative resilience is resilience 3.0, after robustness (1.0) and antifragility (2.0), be…
View article: Associations of Preconception Body Weight, Body Mass Index, and Hypertension with Preeclampsia
Associations of Preconception Body Weight, Body Mass Index, and Hypertension with Preeclampsia Open
Objective: Maximizing preconception health is an important strategy to prevent preeclampsia in pregnancy. Preeclampsia remains a significant cause of maternal and fetal morbidity and mortality. We examined the associations between preconce…
View article: Integrating microbiome science and evolutionary medicine into animal health and conservation
Integrating microbiome science and evolutionary medicine into animal health and conservation Open
Microbiome science has provided groundbreaking insights into human and animal health. Similarly, evolutionary medicine – the incorporation of eco‐evolutionary concepts into primarily human medical theory and practice – is increasingly reco…
View article: FRI406 Maternal Biomarkers Of Adiposity And Stress For Preterm Birth
FRI406 Maternal Biomarkers Of Adiposity And Stress For Preterm Birth Open
Disclosure: G. Mayne: None. P.E. DeWitt: None. J. Wen: None. U. Christians: None. D. Dabelea: None. J. Schulkin: None. K. Hurt: None. Background: Adiponectin is a potent uterine tocolytic and decreases with gestational age, so it could be …
View article: Vaccine hesitancy in pregnant Women: A narrative review
Vaccine hesitancy in pregnant Women: A narrative review Open
Pregnant women are often at higher risk for morbidity and mortality due to contracting vaccine-preventable diseases that result in adverse pregnancy outcomes such as spontaneous abortion, preterm births, and congenital fetal defects. For e…
View article: 0939 Obstetrician-Gynecologists’ knowledge and practice patterns regarding sleep disorders in pregnant patients
0939 Obstetrician-Gynecologists’ knowledge and practice patterns regarding sleep disorders in pregnant patients Open
Introduction Prenatal sleep quality is an important factor in pregnancy and delivery outcomes and prenatal sleep disorders have been linked to a variety of negative maternal/fetal outcomes. At the same time, pregnancy itself is a risk fact…
View article: A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases Open
Genes associated with risk for brain disease exhibit characteristic expression patterns that reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of disease risk genes provide a molecular-based signature,…
View article: Mind in Nature
Mind in Nature Open
A dialogue between contemporary neuroscience and John Dewey's seminal philosophical work Experience and Nature, exploring how the bodily roots of human meaning, selfhood, and values provide wisdom for living. The intersection of cognitive …
View article: Sex Differences in Salt Appetite: Perspectives from Animal Models and Human Studies
Sex Differences in Salt Appetite: Perspectives from Animal Models and Human Studies Open
Salt ingestion by animals and humans has been noted from prehistory. The search for salt is largely driven by a physiological need for sodium. There is a large body of literature on sodium intake in laboratory rats, but the vast majority o…
View article: The fast and the curious: Creative improvisation as action-oriented abduction
The fast and the curious: Creative improvisation as action-oriented abduction Open
Improvisation, understood as a skillful activity, suggests a tension between the constitutive roles of habit and creativity. Cognitive and phenomenological accounts of skill acquisition point to the importance of developing habitual respon…
View article: Hyperexcitability: From Normal Fear to Pathological Anxiety and Trauma
Hyperexcitability: From Normal Fear to Pathological Anxiety and Trauma Open
Hyperexcitability in fear circuits is suggested to be important for development of pathological anxiety and trauma from adaptive mechanisms of fear. Hyperexcitability is proposed to be due to acquired sensitization in fear circuits that pr…
View article: Corticotropin releasing factor (CRF) systems: Promoting cocaine pursuit without distress via incentive motivation
Corticotropin releasing factor (CRF) systems: Promoting cocaine pursuit without distress via incentive motivation Open
Corticotropin releasing factor (CRF) systems in limbic structures are posited to mediate stress-induced relapse in addiction, traditionally by generating distress states that spur drug consumption as attempts at hedonic self-medication. Ye…
View article: Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum supports social novelty preference
Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum supports social novelty preference Open
Social preference, the decision to interact with one member of the same species over another, is a key feature of optimizing social interactions. In rodents, social preference relies on both extrinsic factors, such as sex, strain and kinsh…
View article: Prenatal Genetic Screening and Diagnostic Testing: Assessing Patients' Knowledge, Clinical Experiences, and Utilized Resources in Comparison to Provider's Perceptions
Prenatal Genetic Screening and Diagnostic Testing: Assessing Patients' Knowledge, Clinical Experiences, and Utilized Resources in Comparison to Provider's Perceptions Open
Objective This survey study aimed to assess patient knowledge, clinical resources, and utilized resources about genetic screening and diagnostic testing. Study Design A one-time anonymous paper survey was distributed to 500 patients at a m…
View article: Practices of Sickle Cell Disease Genetic Screening and Testing in the Prenatal Population
Practices of Sickle Cell Disease Genetic Screening and Testing in the Prenatal Population Open
Background Genetic screening and testing has only recently become an accessible assessment for genetic risk. Unfortunately, these technologies have been underutilized in minority populations despite their usefulness for predicting diseases…
View article: Physician attitudes and knowledge on prophylactic salpingectomy in perimenopausal patients
Physician attitudes and knowledge on prophylactic salpingectomy in perimenopausal patients Open
Several factors may affect decision making for prophylactic salpingectomy at the time of hysterectomy however paramount among these is cancer risk reduction. Most physicians found it difficult to discuss and implement a change in care for …
View article: Music and Cephalic Capability
Music and Cephalic Capability Open
Pragmatists views, like those of John Dewey's about music, emphasize the social nature of musical sensibility, instrumental expressions and adaptation to changing circumstances. Indeed, expectancy and violations of those expectations in mu…
View article: Obstetrician-gynecologist willingness to provide medication abortion with removal of the in-person dispensing requirement for mifepristone
Obstetrician-gynecologist willingness to provide medication abortion with removal of the in-person dispensing requirement for mifepristone Open
In order to improve access to medication abortion, the mifepristone Risk Evaluation and Mitigation Strategy should be modified or removed to allow clinicians to prescribe the medication with dispensing by pharmacies, including mail-order p…
View article: Obstetrician patterns of steroid administration for the prenatal management of congenital pulmonary airway malformations
Obstetrician patterns of steroid administration for the prenatal management of congenital pulmonary airway malformations Open
BACKGROUND: Congenital pulmonary airway malformation (CPAM) is the most common prenatally-diagnosed lung malformation. This lesion, classified as macrocystic or microcystic, can lead to significant fetal compromise. Management options incl…