Jay Shetty
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View article: A Systematic Review of Wearable Sensors in Rett Syndrome—What Physiological Markers Are Informative for Monitoring Disease States?
A Systematic Review of Wearable Sensors in Rett Syndrome—What Physiological Markers Are Informative for Monitoring Disease States? Open
Rett syndrome (RTT) presents with a wide range of symptoms spanning various clinical areas. Capturing symptom change as the disorder progresses is challenging. Wearable sensors offer a non-invasive and objective means of monitoring disease…
View article: Acute flaccid myelitis in Europe between 2016 and 2023: indicating the need for better registration
Acute flaccid myelitis in Europe between 2016 and 2023: indicating the need for better registration Open
Background Acute flaccid myelitis (AFM) is a rare polio-like condition affecting mainly children and characterised by severe, often persistent, weakness. It is one of several causes of acute flaccid paralysis (AFP), which manifests as acut…
View article: Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high‐grade brain tumors: Results from a European survey
Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high‐grade brain tumors: Results from a European survey Open
Objective Epilepsy surgery is a standard treatment for drug‐resistant epilepsy, resulting in seizure freedom in a significant number of cases. Although frequently performed for low‐grade brain tumors, it is rarely considered for high‐grade…
View article: Predicting autoimmune etiology in pediatric epilepsy
Predicting autoimmune etiology in pediatric epilepsy Open
This commentary is on the original article by Mori et al. on pages 1319–1328 of this issue.
View article: Functional neurological disorder in children and young people: Incidence, clinical features, and prognosis
Functional neurological disorder in children and young people: Incidence, clinical features, and prognosis Open
Aim To report incidence, demographic and clinical characteristics, and symptom outcome of functional neurological disorder (FND) in children. Method Children diagnosed with FND at a regional children's hospital were prospectively recruited…
View article: Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study
Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study Open
One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application is the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are d…
View article: 858 Outcome of focal epilepsy in children – Scottish population study
858 Outcome of focal epilepsy in children – Scottish population study Open
Aims Epilepsy is reported to affect 63,400 young people in the UK,1 with focal epilepsy accounting for 60% of paediatric epilepsy syndromes.2 Here we report clinical outcomes in a population cohort with focal epilepsy and factors predictin…
View article: 1181 Clinical, health economic and environmental evaluation of a secure, carer recorded, clinical video transfer system for paediatric neurology
1181 Clinical, health economic and environmental evaluation of a secure, carer recorded, clinical video transfer system for paediatric neurology Open
Aims An interactive cloud-based platform allowing patients and carers to upload smartphone video and linked metadata for neurological diagnosis was designed by paediatric neurologists with a technology partner and established in 21 paediat…
View article: Interpretable surface-based detection of focal cortical dysplasias: a MELD study
Interpretable surface-based detection of focal cortical dysplasias: a MELD study Open
Introduction One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application is the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MR…
View article: Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study
Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study Open
Objective Drug‐resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and the impact of lesion location on clinical presentation and surgical outcome are l…
View article: 107 Clinical features of children presenting with prolonged seizures – a data linkage study from a Scottish population cohort
107 Clinical features of children presenting with prolonged seizures – a data linkage study from a Scottish population cohort Open
Background Prolonged seizures (PS) are a common paediatric medical emergency. According to the International League Against Epilepsy (ILAE) PS are now defined as any seizure activity lasting over 5 minutes or where there is incomplete reco…
View article: Children’s understanding of epilepsy: A qualitative study
Children’s understanding of epilepsy: A qualitative study Open
The perspectives of children with epilepsy are valuable for clinicians to understand; assumptions should not be made that children's views can be accessed via parents. Clinicians need to be constantly aware of children's views and ways of …
View article: Epidemiology and outcome of status epilepticus in children: a Scottish population cohort study
Epidemiology and outcome of status epilepticus in children: a Scottish population cohort study Open
Aim To describe the epidemiology and outcomes of convulsive status epilepticus (CSE) since the introduction of buccal midazolam and the change in International League Against Epilepsy definition of CSE to include seizures of at least 5 min…
View article: Early childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants
Early childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants Open
Epilepsies of early childhood are frequently resistant to therapy and often associated with cognitive and behavioural comorbidity. Aetiology focused precision medicine, notably gene-based therapies, may prevent seizures and comorbidities. …
View article: MELD Project: Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia
MELD Project: Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia Open
Drug-resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and the impact of lesion location on clinical presentation and surgical outcome are largely unk…
View article: P08 Epidemiology of epilepsy in early childhood and predictors of outcome: a national population-based prospective cohort study
P08 Epidemiology of epilepsy in early childhood and predictors of outcome: a national population-based prospective cohort study Open
Objectives To calculate the incidence of early childhood–onset epilepsy To report the yield from aetiological investigations in these patients To investigate for predictors of Drug Resistant Epilepsy (DRE) and Global Developmental Delay (G…
View article: G42(P) Epidemiology and outcome of status epilepticus in children with new ILAE definition
G42(P) Epidemiology and outcome of status epilepticus in children with new ILAE definition Open
Background Status Epilepticus (SE) in children carries significant risk of morbidity and mortality. Previous work has predominantly focused on SE ≥30 min but a new ILAE definition has been produced following evidence that seizures ≥5 min a…
View article: P047 Utility of pediatric sleep questionnaire sleep-related breathing disorder questionnaire subscale (PSQ-SRBD) in the prediction of obstructive sleep apnoea (OSA) in children with epilepsy (CWE)
P047 Utility of pediatric sleep questionnaire sleep-related breathing disorder questionnaire subscale (PSQ-SRBD) in the prediction of obstructive sleep apnoea (OSA) in children with epilepsy (CWE) Open
Introduction Epilepsy and OSA are common conditions, affecting 0.5%1 and 6%2 of children respectively. Pilot data utilising the PSQ-SRBD reported a high risk of OSA in 55% of CWE versus 7% of controls.3 This study assessed symptoms of OSA …
View article: Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort
Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort Open
Epilepsy is common in early childhood. In this age group it is associated with high rates of therapy-resistance, and with cognitive, motor, and behavioural comorbidity. A large number of genes, with wide ranging functions, are implicated i…
View article: Treatments in Aicardi–Goutières syndrome
Treatments in Aicardi–Goutières syndrome Open
Comprehensive reviews of the clinical characteristics and pathogenesis of Aicardi–Goutières syndrome ( AGS ), particularly its contextualization within a putative type I interferonopathy framework, already exist. However, recent reports of…
View article: Outcome of paediatric acute flaccid myelitis associated with enterovirus D68: a case series
Outcome of paediatric acute flaccid myelitis associated with enterovirus D68: a case series Open
Enterovirus D68 ( EV ‐D68) is an emerging infection associated with acute flaccid myelitis ( AFM ). Cases of AFM associated with EV ‐D68 infection have increased in recent years and the evidence for a causal link is growing. However, our u…
View article: G319(P) Outcomes following febrile convulsions: a retrospective cohort study
G319(P) Outcomes following febrile convulsions: a retrospective cohort study Open
Febrile convulsions (FC) are seizures in children under five associated with fever. They are reported in 2%–5% of children with good prognosis. However, the risk of epilepsy may be increased. This study reported the first Scottish cohort a…
View article: Analysis of EEG networks and their correlation with cognitive impairment in preschool children with epilepsy
Analysis of EEG networks and their correlation with cognitive impairment in preschool children with epilepsy Open
Objective: Cognitive impairment (CI) is common in children with epilepsy and can have devastating effects on their quality of life and that of their family. Early identification of CI is a priority to improve outcomes, but the current gold…