Explanipedia

Molecular mimicry in multisystem inflammatory syndrome in children Open

Aaron Bodansky, Robert C. Mettelman, Joseph J. Sabatino, Sara E. Vazquez, Janet Chou , et al. · 2024

High seroprevalence of antibodies against arboviruses in postpartum women in Salvador, Brazil Open

Pedro Paulo Bastos Filho, Marcos Vinícius Lima de Oliveira Francisco, Cleiton Silva Santos, Breno Lima de Almeida, Mariellen Santos de Jesus Souza , et al. · 2023

Our data indicate a high prevalence of past ZIKV and DENV infections in the population studied. Most of the participants remain susceptible to future CHIKV infection, highlighting the need for preventive and educational interventions. Our …

A distinct cross-reactive autoimmune response in multisystem inflammatory syndrome in children (MIS-C) Open

Aaron Bodansky, Joseph J. Sabatino, Sara E. Vazquez, Janet Chou, Tanya Novak , et al. · 2023

Multisystem inflammatory syndrome in children (MIS-C) is a severe, post-infectious sequela of SARS-CoV-2 infection, yet the pathophysiological mechanism connecting the infection to the broad inflammatory syndrome remains unknown. Here we l…

Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients Open

Joann Diray‐Arce, Slim Fourati, Naresh Doni Jayavelu, Ravi K. Patel, Cole Maguire , et al. · 2023

The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1-3) to more severe disease course (TG4) and death (TG5)…

Author response: Antibodies to repeat-containing antigens in Plasmodium falciparum are exposure-dependent and short-lived in children in natural malaria infections Open

Madhura Raghavan, Katrina Kalantar, Elias Duarte, Noam Teyssier, Saki Takahashi , et al. · 2023

Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Protection against Pla…

Proteome-wide antigenic profiling in Ugandan cohorts identifies associations between age, exposure intensity, and responses to repeat-containing antigens in <i>Plasmodium falciparum</i> Open

Madhura Raghavan, Katrina Kalantar, Elias Duarte, Noam Teyssier, Saki Takahashi , et al. · 2022

Protection against Plasmodium falciparum , which is primarily antibody-mediated, requires recurrent exposure to develop. The study of both naturally acquired limited immunity and vaccine induced protection against malaria remains critical …

Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and early infancy Open

Mary Prahl, Yarden Golan, Arianna G. Cassidy, Yusuke Matsui, Lin Li , et al. · 2021

Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and early infancy Open

Mary Prahl, Yarden Golan, Arianna G. Cassidy, Yusuke Matsui, Lin Li , et al. · 2021

Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. We evaluated the transplacental …

Inoculation by mosquito induces durable differences in serological profile in non-human primates infected with DENV1 Open

Jayant V. Rajan, Michael K. McCracken, Caleigh Mandel‐Brehm, Greg Gromowski, Simon Pollett , et al. · 2020

Natural dengue virus (DENV) infections are delivered by mosquito bite but how the route of inoculation route could shape the humoral immune response is not well understood. Here, we serologically profiled 20 non-human primates (NHP) from a…

ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens Open

Colin R. Zamecnik, Jayant V. Rajan, Kevin A. Yamauchi, Sabrina A Mann, Gavin M. Sowa , et al. · 2020

Serologic assays are needed to determine SARS-CoV-2 seroprevalence, but poor specificity can overestimate exposures. Here, we built a pan-human coronavirus proteome-wide programmable phage display assay (VirScan) to profile coronavirus ant…

Prevalence and risk factors for latent tuberculosis infection among primary health care workers in Brazil Open

Thiago Nascimento do Prado, Lee W. Riley, Mauro Niskier Sanchez, Geisa Fregona, Renata Lyrio Peres Nóbrega , et al. · 2017

Health care workers (HCW) are at increased risk of latent tuberculosis infection (LTBI) from occupational exposure to Mycobacterium tuberculosis. The objective was to determine the prevalence of and risk factors for LTBI among primary HCW …

A multivariate analysis of CalEnviroScreen: comparing environmental and socioeconomic stressors versus chronic disease Open

Ben K. Greenfield, Jayant V. Rajan, Thomas E. McKone · 2017

Background The health-risk assessment paradigm is shifting from single stressor evaluation towards cumulative assessments of multiple stressors. Recent efforts to develop broad-scale public health hazard datasets provide an opportunity to …

Diabetes increases the risk of recent-transmission tuberculosis in household contacts in São Paulo, Brazil Open

Jayant V. Rajan, Lucilaine Ferrazoli, Eliseu Alves Waldman, Vera Simonsen, P Ferreira , et al. · 2017

Household contact DM was associated with an increased risk of RT TB in a cohort in Brazil, lending support to the active screening of household contacts with DM for TB in Brazil.

Clinical and epidemiological characteristics associated with unfavorable tuberculosis treatment outcomes in TB-HIV co-infected patients in Brazil: a hierarchical polytomous analysis Open

Thiago Nascimento do Prado, Jayant V. Rajan, Angélica Espinosa Miranda, Elias dos Santos Dias, Lorrayne Beliqui Cosme , et al. · 2016

Understanding the barriers to successful adoption and use of a mobile health information system in a community health center in São Paulo, Brazil: a cohort study Open

Jayant V. Rajan, Juliana Baptiste Lauriano da Costa Moura, Gato Gourley, Karina de Moraes Kiso, Alexandre Sizilio , et al. · 2016

In a cohort of formally educated community healthcare workers with high levels of personal computer and cell phone use, we identified no technological barriers to adapting their existing work to a mobile device based system. Transferring c…

Diabetes Mellitus in California: Complications, Modifiers and Spatial Determinants Open

Jayant V. Rajan · 2016

Diabetes mellitus (DM) is a metabolic disease whose prevalence has steadily risen in the United States and globally over the last three decades. In addition to its direct effects on hyperglycemia, DM has a variety of associated complicatio…

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