Jayanth Kumar Narayana
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View article: Integrated multi-omics profiling for risk stratification in Asians with COPD
Integrated multi-omics profiling for risk stratification in Asians with COPD Open
View article: A gut <i>Eggerthella lenta</i> –derived metabolite impairs neutrophil function to aggravate bacterial lung infection
A gut <i>Eggerthella lenta</i> –derived metabolite impairs neutrophil function to aggravate bacterial lung infection Open
The composition of the gut microbiota in patients with bronchiectasis has been proven to be distinct from that of healthy individuals, and this disrupted gut microbiota can exacerbate lung infections. However, the responsible microbes and …
View article: Accelerated Lung Function Decline and Mucus–Microbe Evolution in Chronic Obstructive Pulmonary Disease
Accelerated Lung Function Decline and Mucus–Microbe Evolution in Chronic Obstructive Pulmonary Disease Open
Rationale: Progressive lung function loss is recognized in chronic obstructive pulmonary disease (COPD); however, no study concurrently evaluates how accelerated lung function decline relates to mucus properties and the microbiome i…
View article: Airway “Resistotypes” and Clinical Outcomes in Bronchiectasis
Airway “Resistotypes” and Clinical Outcomes in Bronchiectasis Open
Rationale: Chronic infection and inflammation shapes the airway microbiome in bronchiectasis. Utilizing whole-genome shotgun metagenomics to analyze the airway resistome provides insight into interplay between microbes, resistance g…
View article: Reply to Ward <i>et al.</i>
Reply to Ward <i>et al.</i> Open
"Reply to: The Potential Role of Gastric Microbiology in Respiratory Disease." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Microbial Inflammatory Networks in Bronchiectasis Exacerbators With Pseudomonas aeruginosa
Microbial Inflammatory Networks in Bronchiectasis Exacerbators With Pseudomonas aeruginosa Open
View article: Microbial Dysregulation of the Gut-Lung Axis in Bronchiectasis
Microbial Dysregulation of the Gut-Lung Axis in Bronchiectasis Open
Rationale: Emerging data support the existence of a microbial "gut-lung" axis that remains unexplored in bronchiectasis. Methods: Prospective and concurrent sampling of gut (stool) and lung (sputum) was performed in a cohort …
View article: Sensitisation to recombinant<i>Aspergillus fumigatus</i>allergens and clinical outcomes in COPD
Sensitisation to recombinant<i>Aspergillus fumigatus</i>allergens and clinical outcomes in COPD Open
Background Variable clinical outcomes are reported with fungal sensitisation in chronic obstructive pulmonary disease (COPD), and it remains unclear which fungi and what allergens associate with the poorest outcomes. The use of recombinant…
View article: Microbiomics-focused Data Integration: A Fresh Solve for the Rubik’s Cube of Endophenotyping?
Microbiomics-focused Data Integration: A Fresh Solve for the Rubik’s Cube of Endophenotyping? Open
This is the final version. Available on open access from the American Thoracic Society via the DOI in this record
View article: Similarity network fusion for the integration of multi-omics and microbiomes in respiratory disease
Similarity network fusion for the integration of multi-omics and microbiomes in respiratory disease Open
Advances in platform technologies facilitate the design of largescale “multi-omic” studies that
\nencompass genomic, transcriptomic, proteomic, epigenomic, metabolomic and microbiomic
\ncomponents, each representing different views of a si…
View article: Microbial Dysregulation of the 'Lung-Gut' Axis in High-Risk Bronchiectasis
Microbial Dysregulation of the 'Lung-Gut' Axis in High-Risk Bronchiectasis Open
View article: Integrative microbiomics in bronchiectasis exacerbations
Integrative microbiomics in bronchiectasis exacerbations Open
View article: Mathematical-based microbiome analytics for clinical translation
Mathematical-based microbiome analytics for clinical translation Open
View article: The Healthy Airway Mycobiome in Individuals of Asian Descent
The Healthy Airway Mycobiome in Individuals of Asian Descent Open
View article: Systemic Chitotriosidase Activity Is Associated with Airway Aspergillus and Frequent Exacerbations in Bronchiectasis
Systemic Chitotriosidase Activity Is Associated with Airway Aspergillus and Frequent Exacerbations in Bronchiectasis Open
View article: Metagenomics Reveals a Core Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease
Metagenomics Reveals a Core Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease Open
Rationale: Long-term antibiotic use for managing chronic respiratory disease is increasing; however, the role of the airway resistome and its relationship to host microbiomes remains unknown.Objectives: To evaluate airway res…
View article: “High-Risk” Clinical and Inflammatory Clusters in COPD of Chinese Descent
“High-Risk” Clinical and Inflammatory Clusters in COPD of Chinese Descent Open