Jayden Ross
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View article: α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex
α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex Open
Prenatal nicotine exposure impairs fetal cortical grey matter volume, but the precise cellular mechanisms remain poorly understood. This study elucidates the role of nicotinic acetylcholine receptors (nAChRs) in progenitor cells and radial…
View article: LIF signaling regulates outer radial glial to interneuron fate during human cortical development
LIF signaling regulates outer radial glial to interneuron fate during human cortical development Open
Radial glial (RG) development is essential for cerebral cortex growth and organization. In humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons and glia. However, the mechanisms regulating oRG different…
View article: Tropism of SARS-CoV-2 for human cortical astrocytes
Tropism of SARS-CoV-2 for human cortical astrocytes Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of vital organ systems, with particularly severe impact on respiratory function. Neurological symptoms, which r…
View article: A single-cell atlas of the normal and malformed human brain vasculature
A single-cell atlas of the normal and malformed human brain vasculature Open
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanisms and therapeutic strategies requires a deeper knowledge of cerebrovascular cells in humans. We profiled transcripto…
View article: Picroscope: low-cost system for simultaneous longitudinal biological imaging
Picroscope: low-cost system for simultaneous longitudinal biological imaging Open
Simultaneous longitudinal imaging across multiple conditions and replicates has been crucial for scientific studies aiming to understand biological processes and disease. Yet, imaging systems capable of accomplishing these tasks are econom…
View article: Single-cell epigenomics reveals mechanisms of human cortical development
Single-cell epigenomics reveals mechanisms of human cortical development Open
During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape 1 . In the developing brain, cell fate specification and topographic identity are impo…
View article: Human intermediate progenitor diversity during cortical development
Human intermediate progenitor diversity during cortical development Open
Significance Radial glia (RG) are primary neural stem cells of the cortex, and our current models of human corticogenesis are derived from investigations into the spatiotemporal, transcriptomic, and morphological diversity of human RG. How…
View article: Development of a Low-Cost System for Simultaneous Longitudinal Biological Imaging
Development of a Low-Cost System for Simultaneous Longitudinal Biological Imaging Open
Simultaneous longitudinal imaging across multiple conditions and replicates has been crucial for scientific studies aiming to understand biological processes and disease. Yet, imaging systems capable of accomplishing these tasks are econom…
View article: The Expanding Cell Diversity of the Brain Vasculature
The Expanding Cell Diversity of the Brain Vasculature Open
The cerebrovasculature is essential to brain health and is tasked with ensuring adequate delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is coordinated through a dynamic, multi-directional cellular in…