Jayeeta Basu
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Enhanced Distal Signaling in Human Hippocampal Neurons despite Lower Intrinsic Excitability Open
The hippocampus is critical for memory and spatial navigation, and is central to the pathophysiology of temporal lobe epilepsy — the most common drug-resistant epilepsy. Yet our understanding of the cortico-hippocampal circuit, and neurona…
Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3 Open
Apical and basal dendrites of pyramidal neurons receive anatomically and functionally distinct inputs, implying compartment-level functional diversity during behavior. To test this, we imaged in vivo calcium signals from soma, apical dendr…
Cortico‐hippocampal dysfunction in APP‐KI and PS1 mouse models Open
Background Lateral entorhinal cortex (LEC), medial entorhinal cortex (MEC), and hippocampal area exhibit cell damage due to B‐Amyloid depositions, intracellular tau aggregates, and neurofibrillay tangles. AD mouse models allow us to invest…
Contextual discrimination and representation in APP NL‐G‐F knockin mice Open
Background The entorhinal cortex and hippocampus are loci of early vulnerability in AD. These areas are crucial for episodic memory processing for space and contexts. The majority of AD model mouse imaging and electrode studies utilize sim…
View article: Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations
Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations Open
Summary Systems consolidation relies on coordination between hippocampal sharp-wave ripples (SWRs) and neocortical UP/DOWN states during sleep. However, whether this coupling exists across neocortex and the mechanisms enabling it remain un…
Neural circuits for goal-directed navigation across species Open
Across species, navigation is crucial for finding both resources and shelter. In vertebrates, the hippocampus supports memory-guided goal-directed navigation, whereas in arthropods the central complex supports similar functions. A growing …
ClearScope: a fully integrated light sheet theta microscope for sub-cellular resolution imaging without lateral size constraints Open
Three-dimensional (3D) ex vivo imaging of cleared intact brains of animal models and large human and non-human primate postmortem brain specimens is important for understanding the physiological neural network connectivity patterns and the…
View article: Modeling and Correction of Protein Conformational Disease in iPSC-derived Neurons through Personalized Base Editing
Modeling and Correction of Protein Conformational Disease in iPSC-derived Neurons through Personalized Base Editing Open
Altered protein conformation can cause incurable neurodegenerative disorders. Mutations in SERPINI1 , the gene encoding neuroserpin, can alter protein conformation resulting in cytotoxic aggregation leading to neuronal death. Familial ence…
Entorhinal cortex glutamatergic and GABAergic projections bidirectionally control discrimination and generalization of hippocampal representations Open
Discrimination and generalization are crucial brain-wide functions for memory and object recognition that utilize pattern separation and completion computations. Circuit mechanisms supporting these operations remain enigmatic. We show late…
Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s disease Open
GABAergic inhibitory neurons are the principal source of inhibition in the brain. Traditionally, their role in maintaining the balance of excitation-inhibition has been emphasized. Beyond homeostatic functions, recent circuit mapping and f…
Hippocampus shapes cortical sensory output and novelty coding through a direct feedback circuit Open
To extract behaviorally relevant information from our surroundings, our brains constantly integrate and compare incoming sensory information with those stored as memories. Cortico-hippocampal interactions could mediate such interplay betwe…
Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3 Open
Anatomically segregated apical and basal dendrites of pyramidal neurons receive functionally distinct inputs, but it is unknown if this results in compartment-level functional diversity during behavior. Here we imaged calcium signals from …
Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit Open
The lateral entorhinal cortex (LEC) provides multisensory information to the hippocampus, directly to the distal dendrites of CA1 pyramidal neurons. LEC neurons perform important functions for episodic memory processing, coding for context…
Task-selective place cells show behaviorally driven dynamics during learning and stability during memory recall Open
Decades of work propose that hippocampal activity supports internal representation of learned experiences and contexts, allowing individuals to form long-term memories and quickly adapt behavior to changing environments. However, recent st…
Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit Open
The lateral entorhinal cortex (LEC) provides information about multi-sensory environmental cues to the hippocampus through direct inputs to the distal dendrites of CA1 pyramidal neurons. A growing body of work suggests that LEC neurons per…
Behaviorally emergent hippocampal place maps remain stable during memory recall Open
Summary The hippocampus is critical for the formation and recall of episodic memories 1, 2 which store past experience of events (‘what’) occurring at particular locations (‘where’) in time (‘when’). Hippocampal place cells, pyramidal neur…
The dendritic spatial code: branch-specific place tuning and its experience-dependent decoupling Open
Dendrites of pyramidal neurons integrate different sensory inputs, and non-linear dendritic computations drive feature selective tuning and plasticity. Yet little is known about how dendrites themselves represent the environment, the degre…
Ultrapotent chemogenetics for research and potential clinical applications Open
Improved agonists for chemogenetics Targeting ligand-responsive receptors to specific groups of cells, a strategy known as chemogenetics, is a powerful tool in many neurological applications. There is increasing interest in extending these…
Graphene Nanogrids FET Immunosensor: Signal to Noise Ratio Enhancement Open
Recently, a reproducible and scalable chemical method for fabrication of smooth graphene nanogrids has been reported which addresses the challenges of graphene nanoribbons (GNR). These nanogrids have been found to be capable of attomolar d…
Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition Open
Fine-tuned information flow in the brain In addition to providing well-characterized excitatory inputs, the entorhinal cortex also sends long-range inhibitory projections to the hippocampus. Basu et al. described this input in detail and c…