Jayme Cannon
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View article: Nanoemulsion is an effective antimicrobial for methicillin-resistant <i>Staphylococcus aureus</i> in infected swine skin burn wounds
Nanoemulsion is an effective antimicrobial for methicillin-resistant <i>Staphylococcus aureus</i> in infected swine skin burn wounds Open
Burns are one of the most common injuries in both civilian and combat settings and are difficult to treat. This is particularly true when the wounds are infected with antibiotic-resistant bacteria such as methicillin-resistant Staphylococc…
View article: Delicate Hybrid Laponite–Cyclic Poly(ethylene glycol) Nanoparticles as a Potential Drug Delivery System
Delicate Hybrid Laponite–Cyclic Poly(ethylene glycol) Nanoparticles as a Potential Drug Delivery System Open
The objective of the study was to explore the feasibility of a new drug delivery system using laponite (LAP) and cyclic poly(ethylene glycol) (cPEG). Variously shaped and flexible hybrid nanocrystals were made by both the covalent and phys…
View article: Oxime-Conjugated Dendrimers as Therapeutics for Organophosphate Poisoning
Oxime-Conjugated Dendrimers as Therapeutics for Organophosphate Poisoning Open
Organophosphates (OPs) are a class of organophosphorus compounds which have a general structure of O=P(OR)3. Paraoxon (also known as POX) is an organophosphate found in insecticides often used in agriculture in impoverished countries. OPs …
View article: Effective Treatment of Skin Wounds Co-Infected with Multidrug-Resistant Bacteria with a Novel Nanoemulsion
Effective Treatment of Skin Wounds Co-Infected with Multidrug-Resistant Bacteria with a Novel Nanoemulsion Open
Infections, specifically polymicrobial, can cause serious consequences when it comes to wound treatment. Prolonged treatment with antibiotics can lead to an increased risk of bacterial resistance; co-infections can complicate treatment opt…
View article: Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation<sup>†</sup>
Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation<sup>†</sup> Open
Despite its promising role in the active control of biological functions by light, photocaging remains untested in acetylcholinesterase (AChE), a key enzyme in the cholinergic family. Here, we describe synthesis, photochemical properties a…
View article: Dual acting oximes designed for therapeutic decontamination of reactive organophosphates <i>via</i> catalytic inactivation and acetylcholinesterase reactivation
Dual acting oximes designed for therapeutic decontamination of reactive organophosphates <i>via</i> catalytic inactivation and acetylcholinesterase reactivation Open
Design and in vitro validation of dual acting oximes in the therapeutic decontamination of reactive organophosphates via chemical scavenging and acetylcholinesterase reactivation.
View article: Dendrimer-based posaconazole nanoplatform for antifungal therapy
Dendrimer-based posaconazole nanoplatform for antifungal therapy Open
We examined formulating a new antifungal agent, posaconazole (POS) and its derivatives, with different molecular vehicles. Several combinations of drug and carrier molecules were synthesized, and their antifungal activities were evaluated …
View article: Spacer-Mediated Control of Coumarin Uncaging for Photocaged Thymidine
Spacer-Mediated Control of Coumarin Uncaging for Photocaged Thymidine Open
Despite its importance in the design of photocaged molecules, less attention is focused on linker chemistry than the cage itself. Here, we describe unique uncaging properties displayed by two coumarin-caged thymidine compounds, each conjug…
View article: Inside Cover: A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging (ChemBioChem 1/2017)
Inside Cover: A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging (ChemBioChem 1/2017) Open
The inside cover picture shows the concept of a new binary photocage that enables synchronous controlled release of two payloads linked to a single cage unit. This cage is based on photocleavable thioacetal ortho-nitrobenzaldehyde, and its…
View article: A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging
A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging Open
Despite the immense potential of existing photocaging technology, its application is limited by the paucity of advanced caging tools. Here, we report on the design of a novel thioacetal ortho ‐nitrobenzaldehyde (TNB) dual arm photocage tha…