Jayme Holmes
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View article: Best practices for managing and disseminating resources and outreach and evaluating the impact of the IDG Consortium
Best practices for managing and disseminating resources and outreach and evaluating the impact of the IDG Consortium Open
The Illuminating the Druggable Genome (IDG) consortium generated reagents, biological model systems, data, informatic databases, and computational tools. The Resource Dissemination and Outreach Center (RDOC) played a central administrative…
View article: DrugCentral 2023 extends human clinical data and integrates veterinary drugs
DrugCentral 2023 extends human clinical data and integrates veterinary drugs Open
DrugCentral monitors new drug approvals and standardizes drug information. The current update contains 285 drugs (131 for human use). New additions include: (i) the integration of veterinary drugs (154 for animal use only), (ii) the additi…
View article: Pharos 2023: an integrated resource for the understudied human proteome
Pharos 2023: an integrated resource for the understudied human proteome Open
The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them with small molecules, biologics, or other the…
View article: Getting Started with the IDG KMC Datasets and Tools
Getting Started with the IDG KMC Datasets and Tools Open
The Illuminating the Druggable Genome (IDG) consortium is a National Institutes of Health (NIH) Common Fund program designed to enhance our knowledge of under‐studied proteins, more specifically, proteins unannotated within the three most …
View article: A machine learning platform to estimate anti-SARS-CoV-2 activities
A machine learning platform to estimate anti-SARS-CoV-2 activities Open
Strategies for drug discovery and repositioning are urgently need with respect to COVID-19. Here we present REDIAL-2020, a suite of computational models for estimating small molecule activities in a range of SARS-CoV-2-related assays. Mode…
View article: A machine learning platform to estimate anti-SARS-CoV-2 activities
A machine learning platform to estimate anti-SARS-CoV-2 activities Open
Strategies for drug discovery and repositioning are an urgent need with respect to COVID-19. Here we present "REDIAL-2020", a suite of computational models for estimating small molecule activities in a range of SARS-CoV-2 related assays. M…
View article: TCRD and Pharos 2021: mining the human proteome for disease biology
TCRD and Pharos 2021: mining the human proteome for disease biology Open
In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecul…
View article: DrugCentral 2021 supports drug discovery and repositioning
DrugCentral 2021 supports drug discovery and repositioning Open
DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018 through…
View article: REDIAL-2020: A Suite of Machine Learning Models to Estimate Anti-SARS-CoV-2 Activities
REDIAL-2020: A Suite of Machine Learning Models to Estimate Anti-SARS-CoV-2 Activities Open
Strategies for drug discovery and repositioning are an urgent need with respect to COVID-19. We developed "REDIAL-2020", a suite of machine learning models for estimating small molecule activity from molecular structure, for a range of SAR…
View article: A machine learning platform to estimate anti-SARS-CoV-2 activities
A machine learning platform to estimate anti-SARS-CoV-2 activities Open
Strategies for drug discovery and repositioning are an urgent need with respect to COVID-19. Here we present "REDIAL-2020", a suite of computational models for estimating small molecule activities in a range of SARS-CoV-2 related assa…
View article: REDIAL-2020: A Suite of Machine Learning Models to Estimate Anti-SARS-CoV-2 Activities
REDIAL-2020: A Suite of Machine Learning Models to Estimate Anti-SARS-CoV-2 Activities Open
Strategies for drug discovery and repositioning are an urgent need with respect to COVID-19. We developed "REDIAL-2020", a suite of machine learning models for estimating small molecule activity from molecular structure, for a range of SAR…
View article: DrugCentral 2018: an update
DrugCentral 2018: an update Open
DrugCentral is a drug information resource (http://drugcentral.org) open to the public since 2016 and previously described in the 2017 Nucleic Acids Research Database issue. Since the 2016 release, 103 new approved drugs were updated. The …
View article: Formalizing drug indications on the road to therapeutic intent
Formalizing drug indications on the road to therapeutic intent Open
Therapeutic intent, the reason behind the choice of a therapy and the context in which a given approach should be used, is an important aspect of medical practice. There are unmet needs with respect to current electronic mapping of drug in…
View article: DrugCentral: online drug compendium
DrugCentral: online drug compendium Open
DrugCentral (http://drugcentral.org) is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and other…
View article: Pharos: Collating protein information to shed light on the druggable genome
Pharos: Collating protein information to shed light on the druggable genome Open
The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Gen…