Jayne C. Hope
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View article: Vaccination of calves with Bacille Calmette Guerin (BCG) increased the frequency but did not affect aggregation or clustering of natural killer cells in draining lymph nodes
Vaccination of calves with Bacille Calmette Guerin (BCG) increased the frequency but did not affect aggregation or clustering of natural killer cells in draining lymph nodes Open
Introduction Natural killer (NK) cells are central to innate immune responses but they also influence adaptive immunity. Evidence suggests that NK cells are involved in protective immune responses induced by the Bacille Calmette Guerin (BC…
View article: The cow udder is a potential mixing vessel for influenza A viruses
The cow udder is a potential mixing vessel for influenza A viruses Open
The incursion of high pathogenicity avian influenza A virus (IAV) into US dairy cows is unprecedented in the era of molecular diagnosis and pathogen sequencing. This raises questions over the likelihood of further outbreaks and whether dai…
View article: Characterization of bovine and ovine basal-out and apical-out ileum organoids
Characterization of bovine and ovine basal-out and apical-out ileum organoids Open
Organoids are three-dimensional stem cell-derived structures that differentiate into multiple cell types. Their capacity to self-organize, coupled with the presence of diverse cell types, means that organoids resemble their organ of origin…
View article: Development and characterization of monoclonal antibodies specific for bovine IP-10
Development and characterization of monoclonal antibodies specific for bovine IP-10 Open
Research on chemokines in cattle is hampered by the relative lack of reagents. Bovine IP-10 is an important inflammatory chemokine and a promising diagnostic biomarker for an economically important disease (bovine tuberculosis) caused by i…
View article: Elastic osmotic capsules mimic bolus injection with high release at delayed burst
Elastic osmotic capsules mimic bolus injection with high release at delayed burst Open
The need for repeated administration of vaccines is costly, logistically challenging and leads to reduced compliance. Osmosis-driven swelling and rupture has been proposed as a mechanism for delayed burst release to mimic follow-up (booste…
View article: Opportunities and challenges for the adoption of novel platform technologies to develop veterinary bacterial vaccines
Opportunities and challenges for the adoption of novel platform technologies to develop veterinary bacterial vaccines Open
Vaccine platform technologies provide standardised vehicles for the delivery of diverse antigens to elicit specific immune responses. The deployment of these platforms for novel vaccine development is influenced by a wide range of factors …
View article: Comparative Performance of Ante-Mortem Diagnostic Assays for the Identification of Mycobacterium bovis-Infected Domestic Dogs (Canis lupus familiaris)
Comparative Performance of Ante-Mortem Diagnostic Assays for the Identification of Mycobacterium bovis-Infected Domestic Dogs (Canis lupus familiaris) Open
The domestic dog (Canis lupus familiaris) is a competent host for Mycobacterium (M.) bovis infection but no ante mortem diagnostic tests have been fully validated for this species. The aim of this study was to compare the performance of an…
View article: Cytokine and Chemokine Responses of Peripheral Blood Mononuclear Cells from Dogs Infected with Mycobacterium bovis
Cytokine and Chemokine Responses of Peripheral Blood Mononuclear Cells from Dogs Infected with Mycobacterium bovis Open
Mycobacterial infections are an important emerging zoonosis in companion animals for which diagnostic options remain imperfect, and the canine immunological response to these infections has been poorly investigated. We sought to further de…
View article: Comparative Performance of Ante-Mortem Diagnostic Assays for the Identification of Mycobacterium bovis-Infected Domestic Dogs (<em>Canis lupus familiaris</em>)
Comparative Performance of Ante-Mortem Diagnostic Assays for the Identification of Mycobacterium bovis-Infected Domestic Dogs (<em>Canis lupus familiaris</em>) Open
The domestic dog (Canis lupus familiaris) is a competent host for Mycobacterium (M.) bovis infection but no ante-mortem diagnostic tests have been fully validated for this species. The aim of this study was to compare the performance of an…
View article: Phenotype of bovine mononuclear phagocytes– An update
Phenotype of bovine mononuclear phagocytes– An update Open
Studying mononuclear phagocytes by flow cytometry is challenging due to their phenotypic similarities and the high plasticity of monocytic cells. Despite these challenges, significant progress has been made in cattle research through multi…
View article: Expression of XCR1, CX3CR1, CSF1R and ADGRE1 on subsets of bovine blood dendritic cells and monocytes
Expression of XCR1, CX3CR1, CSF1R and ADGRE1 on subsets of bovine blood dendritic cells and monocytes Open
Among dendritic cells (DC) and monocytes in blood of cattle we can distinguish conventional and plasmacytoid DC (cDC1, cDC2, pDC) and classical, intermediate and nonclassical monocytes (cM, intM, ncM), respectively. Phenotypic definitions …
View article: Differential role of M cells in enteroid infection by Mycobacterium avium subsp. paratuberculosis and Salmonella enterica serovar Typhimurium
Differential role of M cells in enteroid infection by Mycobacterium avium subsp. paratuberculosis and Salmonella enterica serovar Typhimurium Open
Infection of ruminants such as cattle with Mycobacterium avium subsp . paratuberculosis (MAP) causes Johne’s disease, a disease characterized by chronic inflammation of the small intestine and diarrhoea. Infection with MAP is acquired via …
View article: Cattle Cell Atlas: a multi-tissue single cell expression repository for advanced bovine genomics and comparative biology
Cattle Cell Atlas: a multi-tissue single cell expression repository for advanced bovine genomics and comparative biology Open
Systematic characterization of the molecular states of cells in livestock tissues is essential for understanding cellular and genetic mechanisms underlying economically and ecologically important physiological traits. This knowledge contri…
View article: A one health-focused literature review on bovine and zoonotic tuberculosis in Pakistan from the past two decades: challenges and way forward for control
A one health-focused literature review on bovine and zoonotic tuberculosis in Pakistan from the past two decades: challenges and way forward for control Open
Bovine tuberculosis (bTB), caused by Mycobacterium bovis (M. bovis), is a globally prevalent zoonotic infectious disease. World Organization for Animal Health (WOAH) estimates indicate that up to 10% of the total human TB cases in developi…
View article: Canine tuberculosis: A review of 18 new and 565 previously reported confirmed cases
Canine tuberculosis: A review of 18 new and 565 previously reported confirmed cases Open
Cases of canine tuberculosis, a zoonotic infection of significant public health significance, are typically only sporadically reported in the literature. For this observational study, case details were collated both retrospectively and pro…
View article: Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis
Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis Open
Bovine tuberculosis (bTB), caused by Mycobacterium bovis ( M. bovis ) infection in cattle, is an economically devastating chronic disease for livestock worldwide. Efficient disease control measures rely on early and accurate diagnosis usin…
View article: Role of Mce proteins in<i>Mycobacterium avium paratuberculosis</i>infection
Role of Mce proteins in<i>Mycobacterium avium paratuberculosis</i>infection Open
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s Disease, a chronic granulomatous enteritis of ruminants. MAP establishes an infection in the host via the small intestine. This requires the bacteria t…
View article: Protective Efficacy of BCG Vaccination in Calves Vaccinated at Different Ages
Protective Efficacy of BCG Vaccination in Calves Vaccinated at Different Ages Open
Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB), is a globally prevalent pathogen with significant animal welfare, economic and public health impacts. In the UK, the control of bTB relies on detection via tuberculin s…
View article: Development of an enzyme-linked immunosorbent assay for the diagnosis of feline tuberculosis
Development of an enzyme-linked immunosorbent assay for the diagnosis of feline tuberculosis Open
Cases of feline tuberculosis (TB) can be challenging to diagnose. Currently, this is achieved through a combination of mycobacterial culture, polymerase chain reaction (PCR), or interferon-gamma release assay (IGRA); however, these each ha…
View article: The immune response to lumpy skin disease virus in cattle is influenced by inoculation route
The immune response to lumpy skin disease virus in cattle is influenced by inoculation route Open
Lumpy skin disease virus (LSDV) causes severe disease in cattle and water buffalo and is transmitted by hematophagous arthropod vectors. Detailed information of the adaptive and innate immune response to LSDV is limited, hampering the deve…
View article: γδ TCRs Function as Innate-like Receptors in the Bovine γδ T Cell Response against <i>Leptospira</i>
γδ TCRs Function as Innate-like Receptors in the Bovine γδ T Cell Response against <i>Leptospira</i> Open
Leptospira serovar Hardjo are bacterial pathogens of cattle that also cause zoonotic disease in humans. Vaccine-mediated protection against Leptospira serovar Hardjo in cattle is associated with a workshop cluster 1 (WC1)+ γδ T cell respon…
View article: The immune response to lumpy skin disease virus in cattle is influenced by inoculation route
The immune response to lumpy skin disease virus in cattle is influenced by inoculation route Open
Lumpy skin disease virus (LSDV) causes severe disease in cattle and water buffalo and is transmitted by hematophagous arthropod vectors. Detailed information of the adaptive and innate immune response to LSDV is limited, hampering the deve…
View article: The Development of 3D Bovine Intestinal Organoid Derived Models to Investigate Mycobacterium Avium ssp Paratuberculosis Pathogenesis
The Development of 3D Bovine Intestinal Organoid Derived Models to Investigate Mycobacterium Avium ssp Paratuberculosis Pathogenesis Open
Mycobacterium avium subspecies paratuberculosis (MAP) is the etiological agent of Johne's Disease, a chronic enteritis of ruminants prevalent across the world. It is estimated that approximately 50% of UK dairy herds are infected with MAP,…