Jayne Ness
YOU?
Author Swipe
View article: Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis
Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis Open
Background: Age is the strongest factor determining disease expression in multiple sclerosis (MS). We previously demonstrated biological age acceleration in pediatric-onset MS (POMS) compared to controls with both epigenetic clocks (DNAm) …
View article: Real‐World Effectiveness of Switching to Oral or Infusion Versus Injectable Disease‐Modifying Therapy in Pediatric Multiple Sclerosis
Real‐World Effectiveness of Switching to Oral or Infusion Versus Injectable Disease‐Modifying Therapy in Pediatric Multiple Sclerosis Open
Objective To assess real‐world effectiveness of switching disease‐modifying therapy (DMT) in pediatric multiple sclerosis (MS) and clinically isolated syndrome (CIS) initially treated with platform injectables on disease activity. Methods …
View article: Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis
Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis Open
Background and Objectives The genetic basis of adult-onset multiple sclerosis (MS) is well-studied, but less is known about pediatric-onset MS (pedMS), comprising approximately 5% of all MS onsets. Mendelian randomization (MR) studies have…
View article: Early Adversity and Socioeconomic Factors in Pediatric Multiple Sclerosis
Early Adversity and Socioeconomic Factors in Pediatric Multiple Sclerosis Open
Low socioeconomic status at the neighborhood level may increase the risk of POMS while high parental education may be protective against POMS. Although we did not find associations of other evaluated prenatal or postnatal adversities with …
View article: Impact of race and socioeconomic deprivation on clinical outcomes and healthcare utilization in pediatric multiple sclerosis
Impact of race and socioeconomic deprivation on clinical outcomes and healthcare utilization in pediatric multiple sclerosis Open
Background Health disparities in adult-onset multiple sclerosis have been identified in the Black/African American (AA) population. A higher relapse rate has been suggested in Black/AA patients with pediatric-onset MS (POMS), but little wo…
View article: Characteristics of pediatric patients with multiple sclerosis and related disorders infected with SARS-CoV-2
Characteristics of pediatric patients with multiple sclerosis and related disorders infected with SARS-CoV-2 Open
Background: Pediatric patients with multiple sclerosis (POMS) and related disorders, clinically isolated syndrome (CIS), myelin oligodendrocyte glycoprotein antibody disorder (MOGAD), and neuromyelitis optica spectrum disorder (NMOSD), are…
View article: Therapeutic Response in Pediatric Neuromyelitis Optica Spectrum Disorder
Therapeutic Response in Pediatric Neuromyelitis Optica Spectrum Disorder Open
This study provides Class IV evidence that use of disease-modifying treatments is associated with a lowered annualized relapse rate in children with NMOSD AQP4+.
View article: Association Between Time Spent Outdoors and Risk of Multiple Sclerosis
Association Between Time Spent Outdoors and Risk of Multiple Sclerosis Open
If this is a causal association, spending more time in the sun during summer may be strongly protective against developing pediatric MS, as well as residing in a sunnier location.
View article: Gut microbiome is associated with multiple sclerosis activity in children
Gut microbiome is associated with multiple sclerosis activity in children Open
Objective To identify features of the gut microbiome associated with multiple sclerosis activity over time. Methods We used 16S ribosomal RNA sequencing from stool of 55 recently diagnosed pediatric‐onset multiple sclerosis patients. Micro…
View article: Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis
Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis Open
The increased rates of autoimmune disorders, including thyroid disorders and MS among families of patients with pediatric MS, suggest shared genetic factors among families with children diagnosed with pediatric MS.
View article: Pediatric Multiple Sclerosis Severity Score in a large US cohort
Pediatric Multiple Sclerosis Severity Score in a large US cohort Open
Persons with POMS exhibit lower EDSS scores compared to persons with adult-onset MS. Use of a Ped-MSSS model may provide an alternative to EDSS scoring in clinical assessment of disease severity and disability accrual.
View article: Improved relapse recovery in paediatric compared to adult multiple sclerosis
Improved relapse recovery in paediatric compared to adult multiple sclerosis Open
Incomplete relapse recovery contributes to disability accrual and earlier onset of secondary progressive multiple sclerosis. We sought to investigate the effect of age on relapse recovery. We identified patients with multiple sclerosis fro…
View article: Comparison of children with acute flaccid myeltis before and after 2014
Comparison of children with acute flaccid myeltis before and after 2014 Open
The groups had more similarities than differences but with a more inflammatory picture in the post-2014 patients. The constellation of cervical cord gray matter, brainstem, and nerve root/CE thickening should raise suspicion for AFM in the…
View article: mi<scp>RNA</scp>contributions to pediatric‐onset multiple sclerosis inferred from<scp>GWAS</scp>
mi<span>RNA</span>contributions to pediatric‐onset multiple sclerosis inferred from<span>GWAS</span> Open
Objective Onset of multiple sclerosis ( MS ) occurs in childhood for approximately 5% of cases (pediatric MS , or ped‐ MS ). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from micro …
View article: Vitamin D genes influence MS relapses in children
Vitamin D genes influence MS relapses in children Open
Objective: The aim of this study was to determine whether a vitamin D genetic risk score (vitDGRS) is associated with 25-hydroxyvitamin D (25(OH)D) level and multiple sclerosis (MS) relapses in children. Methods: DNA samples were typed for…
View article: Clinical trials of disease-modifying agents in pediatric MS
Clinical trials of disease-modifying agents in pediatric MS Open
A primary goal is to ensure high-quality evidence-based treatment for children and adolescents with MS, which will improve our understanding of the safety of these agents and remove regulatory or insurance-based limitations in access to tr…
View article: Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry
Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry Open
Multiple sclerosis (MS) is an autoimmune disease with high prevalence among populations of northern European ancestry. Past studies have shown that exposure to ultraviolet radiation could explain the difference in MS prevalence across the …
View article: Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis
Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis Open
Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisi…
View article: Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US
Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US Open
Newer DMTs are often used in pediatric MS, and have similar short-term safety, tolerability, and side effect profiles as in adults. These findings may help inform pediatric MS management.
View article: Several household chemical exposures are associated with pediatric‐onset multiple sclerosis
Several household chemical exposures are associated with pediatric‐onset multiple sclerosis Open
Background There is limited information about the potential associations of multiple sclerosis ( MS ) and commonly used household chemicals. Methods We performed a case‐control study of exposures to common household chemicals during childh…
View article: Urban air quality and associations with pediatric multiple sclerosis
Urban air quality and associations with pediatric multiple sclerosis Open
Background We previously identified air quality as a risk factor of interest for pediatric multiple sclerosis. The purpose of this study is to more closely examine the association between the six criteria air pollutants and pediatric MS as…
View article: Heterogeneity in association of remote herpesvirus infections and pediatric <scp>MS</scp>
Heterogeneity in association of remote herpesvirus infections and pediatric <span>MS</span> Open
Objective While prior Epstein–Barr virus ( EBV ) infection has been consistently associated with subsequent risk of developing multiple sclerosis ( MS ), the association with other common herpesviruses has been more controversial. Our obje…
View article: Pediatric multiple sclerosis: current perspectives on health behaviors
Pediatric multiple sclerosis: current perspectives on health behaviors Open
Participation in health behaviors, particularly physical activity, diet, and sleep, may have benefits for POMS. Nevertheless, there are currently no interventions targeting promotion of these behaviors and examining the benefits of managin…
View article: Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis
Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis Open
Objective The role of diet in multiple sclerosis (MS) course remains largely unknown. Children with MS have a higher relapse rate compared with MS in adults. Thus, studying the effect of diet on relapse rate in this age group is likely to …
View article: Genetic risk factors for pediatric-onset multiple sclerosis
Genetic risk factors for pediatric-onset multiple sclerosis Open
Background: Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. Objective: We comprehensively investigated the association between established major histocompat…